Human Gene NEUROG2 (ENST00000313341.4_7) from GENCODE V47lift37
  Description: neurogenin 2 (from RefSeq NM_024019.4)
Gencode Transcript: ENST00000313341.4_7
Gencode Gene: ENSG00000178403.4_9
Transcript (Including UTRs)
   Position: hg19 chr4:113,434,672-113,437,336 Size: 2,665 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr4:113,435,813-113,436,631 Size: 819 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:113,434,672-113,437,336)mRNA (may differ from genome)Protein (272 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NGN2_HUMAN
DESCRIPTION: RecName: Full=Neurogenin-2; Short=NGN-2; AltName: Full=Class A basic helix-loop-helix protein 8; Short=bHLHa8; AltName: Full=Protein atonal homolog 4;
FUNCTION: Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').
SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein (By similarity).
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NEUROG2
Diseases sorted by gene-association score: partial fetal alcohol syndrome (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.90 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 16.39 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -146.60335-0.438 Picture PostScript Text
3' UTR -313.501141-0.275 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011598 - HLH_dom

Pfam Domains:
PF00010 - Helix-loop-helix DNA-binding domain

SCOP Domains:
47459 - HLH, helix-loop-helix DNA-binding domain

ModBase Predicted Comparative 3D Structure on Q9H2A3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677 DNA binding
GO:0046983 protein dimerization activity
GO:0070888 E-box binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0030154 cell differentiation
GO:0030182 neuron differentiation
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  LF206333 - JP 2014500723-A/13836: Polycomb-Associated Non-Coding RNAs.
BC036847 - Homo sapiens neurogenin 2, mRNA (cDNA clone MGC:46562 IMAGE:5247719), complete cds.
JD052530 - Sequence 33554 from Patent EP1572962.
JD227379 - Sequence 208403 from Patent EP1572962.
LF211930 - JP 2014500723-A/19433: Polycomb-Associated Non-Coding RNAs.
JD252861 - Sequence 233885 from Patent EP1572962.
JD353598 - Sequence 334622 from Patent EP1572962.
JD543802 - Sequence 524826 from Patent EP1572962.
JD066906 - Sequence 47930 from Patent EP1572962.
LF212966 - JP 2014500723-A/20469: Polycomb-Associated Non-Coding RNAs.
JD048096 - Sequence 29120 from Patent EP1572962.
LF353274 - JP 2014500723-A/160777: Polycomb-Associated Non-Coding RNAs.
JD232217 - Sequence 213241 from Patent EP1572962.
JD344350 - Sequence 325374 from Patent EP1572962.
JD124021 - Sequence 105045 from Patent EP1572962.
JD253134 - Sequence 234158 from Patent EP1572962.
JD405385 - Sequence 386409 from Patent EP1572962.
AB464634 - Synthetic construct DNA, clone: pF1KB9631, Homo sapiens NEUROG2 gene for neurogenin 2, without stop codon, in Flexi system.
JD217301 - Sequence 198325 from Patent EP1572962.
JD458558 - Sequence 439582 from Patent EP1572962.
LF362125 - JP 2014500723-A/169628: Polycomb-Associated Non-Coding RNAs.
JD055323 - Sequence 36347 from Patent EP1572962.
JD056112 - Sequence 37136 from Patent EP1572962.
JD373054 - Sequence 354078 from Patent EP1572962.
JD498901 - Sequence 479925 from Patent EP1572962.
MA441910 - JP 2018138019-A/13836: Polycomb-Associated Non-Coding RNAs.
MA447507 - JP 2018138019-A/19433: Polycomb-Associated Non-Coding RNAs.
MA448543 - JP 2018138019-A/20469: Polycomb-Associated Non-Coding RNAs.
MA588851 - JP 2018138019-A/160777: Polycomb-Associated Non-Coding RNAs.
MA597702 - JP 2018138019-A/169628: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ATOH4, BHLHA8, ENST00000313341.1, ENST00000313341.2, ENST00000313341.3, NGN2, NGN2_HUMAN, NM_024019, Q8N416, Q9H2A3, uc317pjt.1, uc317pjt.2
UCSC ID: ENST00000313341.4_7
RefSeq Accession: NM_024019.4
Protein: Q9H2A3 (aka NGN2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.