ID:NEXN_HUMAN DESCRIPTION: RecName: Full=Nexilin; AltName: Full=F-actin-binding protein; AltName: Full=Nelin; FUNCTION: Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. SUBUNIT: Interacts with F-actin. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Cell junction, adherens junction (By similarity). Cytoplasm, myofibril, sarcomere, Z line (By similarity). Note=Localizes to the cell-matrix AJ. Not found at the cell-cell AJ (By similarity). TISSUE SPECIFICITY: Abundantly expressed in heart and skeletal muscle, and at lower levels in placenta, lung, liver and pancreas. Also expressed in HeLaS3 and MOLT-4 cell lines. DISEASE: Defects in NEXN are the cause of cardiomyopathy dilated type 1CC (CMD1CC) [MIM:613122]. A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. DISEASE: Defects in NEXN are the cause of familial hypertrophic cardiomyopathy type 20 (CMH20) [MIM:613876]. CMH20 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. SIMILARITY: Contains 1 Ig-like (immunoglobulin-like) domain. SEQUENCE CAUTION: Sequence=AAH17827.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAH55084.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH55084.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAI11396.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI14445.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI14446.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB71622.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q0ZGT2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
