ID:IKBL1_HUMAN DESCRIPTION: RecName: Full=NF-kappa-B inhibitor-like protein 1; AltName: Full=Inhibitor of kappa B-like protein; Short=I-kappa-B-like protein; Short=IkappaBL; AltName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1; FUNCTION: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. SUBUNIT: Interacts with CACTIN (via N-terminus domain); the interaction occurs in a proinflammatory-independent manner. SUBCELLULAR LOCATION: Nucleus. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with CACTIN in the nucleus. TISSUE SPECIFICITY: Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes. DISEASE: Defects in NFKBIL1 are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. SIMILARITY: Contains 2 ANK repeats. SEQUENCE CAUTION: Sequence=BAG62473.1; Type=Erroneous termination; Positions=255; Note=Translated as Glu;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UBC1
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
