ID:NFRKB_HUMAN DESCRIPTION: RecName: Full=Nuclear factor related to kappa-B-binding protein; AltName: Full=DNA-binding protein R kappa-B; AltName: Full=INO80 complex subunit G; FUNCTION: Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. SUBUNIT: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N- terminus of INO80. Interacts with UCHL5; NFRKB competes with ADRM1 for interaction with UCHL5. INTERACTION: Q9Y5K5:UCHL5; NbExp=9; IntAct=EBI-2511210, EBI-1051183; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in thymus, brain, testes, spleen and liver. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the NFRKB family. SEQUENCE CAUTION: Sequence=AAA17871.1; Type=Frameshift; Positions=1267;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6P4R8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006281 DNA repair GO:0006310 DNA recombination GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006954 inflammatory response GO:0006974 cellular response to DNA damage stimulus GO:0016579 protein deubiquitination
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
