ID:NFYB_HUMAN DESCRIPTION: RecName: Full=Nuclear transcription factor Y subunit beta; AltName: Full=CAAT box DNA-binding protein subunit B; AltName: Full=Nuclear transcription factor Y subunit B; Short=NF-YB; FUNCTION: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes. SUBUNIT: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. INTERACTION: P23511:NFYA; NbExp=4; IntAct=EBI-389728, EBI-389739; Q13952:NFYC; NbExp=3; IntAct=EBI-389728, EBI-389755; SUBCELLULAR LOCATION: Nucleus. DOMAIN: Can be divided into 3 domains: the weakly conserved A domain, the highly conserved B domain thought to be involved in subunit interaction and DNA binding, and the Glu-rich C domain. SIMILARITY: Belongs to the NFYB/HAP3 subunit family. SEQUENCE CAUTION: Sequence=CAA42230.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P25208
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding GO:0044877 macromolecular complex binding GO:0046982 protein heterodimerization activity GO:0070491 repressing transcription factor binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0045540 regulation of cholesterol biosynthetic process GO:0045893 positive regulation of transcription, DNA-templated GO:1990830 cellular response to leukemia inhibitory factor
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
