ID:TNR16_HUMAN DESCRIPTION: RecName: Full=Tumor necrosis factor receptor superfamily member 16; AltName: Full=Gp80-LNGFR; AltName: Full=Low affinity neurotrophin receptor p75NTR; AltName: Full=Low-affinity nerve growth factor receptor; Short=NGF receptor; AltName: Full=p75 ICD; AltName: CD_antigen=CD271; Flags: Precursor; FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor (By similarity). Interacts with LINGO1. INTERACTION: P05067:APP; NbExp=4; IntAct=EBI-1387782, EBI-77613; P33681:CD80; NbExp=3; IntAct=EBI-1387782, EBI-1031024; P25233:Ndn (xeno); NbExp=3; IntAct=EBI-1387782, EBI-1801080; Q9CPR8:Ndnl2 (xeno); NbExp=3; IntAct=EBI-1387782, EBI-5529102; SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DOMAIN: Death domain is responsible for interaction with RANBP9. DOMAIN: The extracellular domain is responsible for interaction with NTRK1 (By similarity). PTM: N- and O-glycosylated. PTM: O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. PTM: Phosphorylated on serine residues. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 4 TNFR-Cys repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P08138
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006886 intracellular protein transport GO:0006915 apoptotic process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006954 inflammatory response GO:0006955 immune response GO:0007165 signal transduction GO:0007266 Rho protein signal transduction GO:0007275 multicellular organism development GO:0007399 nervous system development GO:0007411 axon guidance GO:0010977 negative regulation of neuron projection development GO:0030154 cell differentiation GO:0031293 membrane protein intracellular domain proteolysis GO:0032496 response to lipopolysaccharide GO:0032922 circadian regulation of gene expression GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0042593 glucose homeostasis GO:0043065 positive regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0048011 neurotrophin TRK receptor signaling pathway GO:0048511 rhythmic process GO:0050771 negative regulation of axonogenesis GO:0050772 positive regulation of axonogenesis GO:0051402 neuron apoptotic process GO:0097190 apoptotic signaling pathway GO:1900182 positive regulation of protein localization to nucleus GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1904646 cellular response to beta-amyloid GO:2001273 regulation of glucose import in response to insulin stimulus
LF209275 - JP 2014500723-A/16778: Polycomb-Associated Non-Coding RNAs. AK313654 - Homo sapiens cDNA, FLJ94232, Homo sapiens nerve growth factor receptor (TNFR superfamily, member16) (NGFR), mRNA. LF213988 - JP 2014500723-A/21491: Polycomb-Associated Non-Coding RNAs. JA482181 - Sequence 164 from Patent WO2011072091. JE980473 - Sequence 164 from Patent EP2862929. BC050309 - Homo sapiens nerve growth factor receptor (TNFR superfamily, member 16), mRNA (cDNA clone MGC:48326 IMAGE:5263715), complete cds. M14764 - Human nerve growth factor receptor mRNA, complete cds. AK303278 - Homo sapiens cDNA FLJ51424 complete cds, highly similar to Tumor necrosis factor receptor superfamilymember 16 precursor. MA449565 - JP 2018138019-A/21491: Polycomb-Associated Non-Coding RNAs. MA444852 - JP 2018138019-A/16778: Polycomb-Associated Non-Coding RNAs. LF327419 - JP 2014500723-A/134922: Polycomb-Associated Non-Coding RNAs. JD449492 - Sequence 430516 from Patent EP1572962. JD380189 - Sequence 361213 from Patent EP1572962. JD216662 - Sequence 197686 from Patent EP1572962. JD406445 - Sequence 387469 from Patent EP1572962. JD360008 - Sequence 341032 from Patent EP1572962. JD192945 - Sequence 173969 from Patent EP1572962. JD161191 - Sequence 142215 from Patent EP1572962. LF327418 - JP 2014500723-A/134921: Polycomb-Associated Non-Coding RNAs. JD270843 - Sequence 251867 from Patent EP1572962. JD147561 - Sequence 128585 from Patent EP1572962. JD515109 - Sequence 496133 from Patent EP1572962. JD189551 - Sequence 170575 from Patent EP1572962. JD191167 - Sequence 172191 from Patent EP1572962. LF327417 - JP 2014500723-A/134920: Polycomb-Associated Non-Coding RNAs. JD445496 - Sequence 426520 from Patent EP1572962. JD351501 - Sequence 332525 from Patent EP1572962. JD382488 - Sequence 363512 from Patent EP1572962. LF327416 - JP 2014500723-A/134919: Polycomb-Associated Non-Coding RNAs. JD335923 - Sequence 316947 from Patent EP1572962. JD459396 - Sequence 440420 from Patent EP1572962. JD206927 - Sequence 187951 from Patent EP1572962. JD273999 - Sequence 255023 from Patent EP1572962. JD210060 - Sequence 191084 from Patent EP1572962. LF327415 - JP 2014500723-A/134918: Polycomb-Associated Non-Coding RNAs. JD477953 - Sequence 458977 from Patent EP1572962. JD484168 - Sequence 465192 from Patent EP1572962. JD173216 - Sequence 154240 from Patent EP1572962. JD381348 - Sequence 362372 from Patent EP1572962. JD103246 - Sequence 84270 from Patent EP1572962. JD391251 - Sequence 372275 from Patent EP1572962. JD449924 - Sequence 430948 from Patent EP1572962. JD449703 - Sequence 430727 from Patent EP1572962. JD392235 - Sequence 373259 from Patent EP1572962. JD194993 - Sequence 176017 from Patent EP1572962. JD161314 - Sequence 142338 from Patent EP1572962. JD497146 - Sequence 478170 from Patent EP1572962. JD478778 - Sequence 459802 from Patent EP1572962. JD100098 - Sequence 81122 from Patent EP1572962. LF327414 - JP 2014500723-A/134917: Polycomb-Associated Non-Coding RNAs. JD138969 - Sequence 119993 from Patent EP1572962. JD268685 - Sequence 249709 from Patent EP1572962. JD172598 - Sequence 153622 from Patent EP1572962. JD346860 - Sequence 327884 from Patent EP1572962. JD390586 - Sequence 371610 from Patent EP1572962. JD551316 - Sequence 532340 from Patent EP1572962. JD310185 - Sequence 291209 from Patent EP1572962. JD464333 - Sequence 445357 from Patent EP1572962. JD192981 - Sequence 174005 from Patent EP1572962. JD413246 - Sequence 394270 from Patent EP1572962. JD127224 - Sequence 108248 from Patent EP1572962. JD431692 - Sequence 412716 from Patent EP1572962. JD232137 - Sequence 213161 from Patent EP1572962. MA562996 - JP 2018138019-A/134922: Polycomb-Associated Non-Coding RNAs. MA562995 - JP 2018138019-A/134921: Polycomb-Associated Non-Coding RNAs. MA562994 - JP 2018138019-A/134920: Polycomb-Associated Non-Coding RNAs. MA562993 - JP 2018138019-A/134919: Polycomb-Associated Non-Coding RNAs. MA562992 - JP 2018138019-A/134918: Polycomb-Associated Non-Coding RNAs. MA562991 - JP 2018138019-A/134917: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_ngfPathway - Nerve growth factor pathway (NGF) h_erkPathway - Erk1/Erk2 Mapk Signaling pathway h_cdk5Pathway - Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway
Reactome (by CSHL, EBI, and GO)
Protein P08138 (Reactome details) participates in the following event(s):
R-HSA-193636 p75NTR interacts with the NOGO receptor R-HSA-193653 NGF homodimer binds to p75NTR R-HSA-193668 p75NTR and RHOA-GDI interact R-HSA-193679 alpha-secretase cleaves the p75NTR extracellular domain R-HSA-193700 p75NTR ICD signals to NF-kB R-HSA-193702 Part of the ICD migrates to the nucleus R-HSA-193682 gamma-secretase cleaves the p75NTR transmembrane domain R-HSA-209532 The p75NTR C-terminal fragment enters endosomes R-HSA-193642 Binding of pro-NGF to p75NTR:sortilin R-HSA-193646 NGF binding to p75NTR inactivates RHOA R-HSA-209573 p75NTR:NgR complex interacts with the axonal inhibitor LINGO1 R-HSA-193643 PRDM4 (SC1) binds to p75NTR R-HSA-193650 p75NTR binds to NADE R-HSA-193656 p75NTR interacts with RIP2 R-HSA-193677 NRIF binds to p75NTR R-HSA-193686 p75NTR interacts with IRAK:MYD88 R-HSA-205115 NGF:p75NTR complex binds to NRAGE R-HSA-205112 gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 R-HSA-193655 Myelin components can interact with p75NTR:NgR:LINGO1 R-HSA-204981 14-3-3epsilon attentuates NADE-related apoptosis R-HSA-204958 NRAGE sequesters CHE1 in the cytoplasm R-HSA-193669 TRAF6 binds to p75NTR:NRIF R-HSA-193703 IKKbeta is activated R-HSA-193694 p62 is recruited and forms a complex with TRAF6 R-HSA-193665 MYD88 dissociates R-HSA-193647 IRAK is activated R-HSA-193695 IRAK interacts with TRAF6 R-HSA-193672 Sphingomyelinase is activated by the NGF:p75NTR complex R-HSA-9012761 The p75NTR:NgR:MDGI binds RHOA-GDI R-HSA-205117 p75NTR:NADE promotes caspase2/3 activation R-HSA-205132 NRAGE activates JNK R-HSA-193705 IKKbeta phosphorylates IkB causing NF-kB to dissociate R-HSA-193641 IKK-beta is recruited R-HSA-193684 p62 recruits an atypical PKC R-HSA-193696 The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA R-HSA-204949 NRIF and TRAF6 may activate JNK R-HSA-193634 Axonal growth inhibition (RHOA activation) R-HSA-205017 NFG and proNGF binds to p75NTR R-HSA-209563 Axonal growth stimulation R-HSA-193692 Regulated proteolysis of p75NTR R-HSA-193670 p75NTR negatively regulates cell cycle via SC1 R-HSA-205025 NADE modulates death signalling R-HSA-209543 p75NTR recruits signalling complexes R-HSA-205043 NRIF signals cell death from the nucleus R-HSA-193648 NRAGE signals death through JNK R-HSA-193697 p75NTR regulates axonogenesis R-HSA-193704 p75 NTR receptor-mediated signalling R-HSA-209560 NF-kB is activated and signals survival R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE R-HSA-193639 p75NTR signals via NF-kB R-HSA-193681 Ceramide signalling R-HSA-73887 Death Receptor Signalling R-HSA-162582 Signal Transduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
