Human Gene NLN (ENST00000380985.10_4) from GENCODE V47lift37

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Description: neurolysin (from RefSeq NM_020726.5)
Gencode Transcript: ENST00000380985.10_4
Gencode Gene: ENSG00000123213.23_16
Transcript (Including UTRs)
Position: hg19 chr5:65,018,032-65,125,111 Size: 107,080 Total Exon Count: 13 Strand: +
Coding Region
Position: hg19 chr5:65,018,201-65,118,743 Size: 100,543 Coding Exon Count: 13

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr5:65,018,032-65,125,111)			mRNA (may differ from genome)		Protein (704 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: NEUL_HUMAN DESCRIPTION: RecName: Full=Neurolysin, mitochondrial; EC=3.4.24.16; AltName: Full=Angiotensin-binding protein; AltName: Full=Microsomal endopeptidase; Short=MEP; AltName: Full=Mitochondrial oligopeptidase M; AltName: Full=Neurotensin endopeptidase; Flags: Precursor; FUNCTION: Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A (By similarity). CATALYTIC ACTIVITY: Preferential cleavage in neurotensin: 10- Pro-\|-Tyr-11. COFACTOR: Binds 1 zinc ion per subunit (By similarity). SUBCELLULAR LOCATION: Mitochondrion intermembrane space (By similarity). Cytoplasm (By similarity). SIMILARITY: Belongs to the peptidase M3 family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen C016403 2,4-dinitrotoluene C028451 3,4,3',4'-tetrachlorobiphenyl C075773 4-phenylbutyric acid D001564 Benzo(a)pyrene D003993 Dibutyl Phthalate D004041 Dietary Fats D004051 Diethylhexyl Phthalate D019833 Genistein D007649 Ketamine D015741 Metribolone D010634 Phenobarbital D013749 Tetrachlorodibenzodioxin D014241 Trichloroethylene D014635 Valproic Acid C018021 cobaltous chloride C006253 pirinixic acid C015559 trimellitic anhydride

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 4.63 RPKM in Cells - Cultured fibroblasts Total median expression: 89.08 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-83.60	169	-0.495	Picture	PostScript	Text
3' UTR	-1684.00	6368	-0.264	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR024079 - MetalloPept_cat_dom
IPR024077 - Neurolysin/TOP_dom2
IPR024080 - Neurolysin/TOP_N
IPR001567 - Pept_M3A_M3B

Pfam Domains:
PF01432 - Peptidase family M3

SCOP Domains:
55486 - Metalloproteases ("zincins"), catalytic domain

ModBase Predicted Comparative 3D Structure on Q9BYT8


Front	Top	Side

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Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0004222 metalloendopeptidase activity GO:0008233 peptidase activity GO:0008237 metallopeptidase activity GO:0016787 hydrolase activity GO:0042277 peptide binding GO:0046872 metal ion binding Biological Process: GO:0006111 regulation of gluconeogenesis GO:0006508 proteolysis GO:0006518 peptide metabolic process GO:1902809 regulation of skeletal muscle fiber differentiation Cellular Component: GO:0005576 extracellular region GO:0005737 cytoplasm GO:0005739 mitochondrion GO:0005758 mitochondrial intermembrane space GO:0005886 plasma membrane

Descriptions from all associated GenBank mRNAs


	AK096416 - Homo sapiens cDNA FLJ39097 fis, clone NTONG2000977, highly similar to Neurolysin, mitochondrial precursor (EC 3.4.24.16). AK292803 - Homo sapiens cDNA FLJ76106 complete cds, highly similar to Homo sapiens neurolysin (metallopeptidase M3 family) (NLN), mRNA. BC001644 - Homo sapiens neurolysin (metallopeptidase M3 family), mRNA (cDNA clone MGC:2361 IMAGE:2958628), complete cds. BC004985 - Homo sapiens neurolysin (metallopeptidase M3 family), mRNA (cDNA clone MGC:3978 IMAGE:2958628), complete cds. AJ300837 - Homo sapiens mRNA for neurolysin. JD200336 - Sequence 181360 from Patent EP1572962. JD318782 - Sequence 299806 from Patent EP1572962. JD524647 - Sequence 505671 from Patent EP1572962. AB463138 - Synthetic construct DNA, clone: pF1KA1226, Homo sapiens NLN gene for neurolysin, without stop codon, in Flexi system. CU674806 - Synthetic construct Homo sapiens gateway clone IMAGE:100017425 5' read NLN mRNA. KJ902956 - Synthetic construct Homo sapiens clone ccsbBroadEn_12350 NLN gene, encodes complete protein. AB033052 - Homo sapiens KIAA1226 mRNA for KIAA1226 protein. AK027602 - Homo sapiens cDNA FLJ14696 fis, clone NT2RP2005775, highly similar to NEUROLYSIN PRECURSOR (EC 3.4.24.16). AL834241 - Homo sapiens mRNA; cDNA DKFZp564F123 (from clone DKFZp564F123). JD143152 - Sequence 124176 from Patent EP1572962. JD362610 - Sequence 343634 from Patent EP1572962. JD365139 - Sequence 346163 from Patent EP1572962. JD549481 - Sequence 530505 from Patent EP1572962. JD434549 - Sequence 415573 from Patent EP1572962. JD312855 - Sequence 293879 from Patent EP1572962. JD491627 - Sequence 472651 from Patent EP1572962. JD432834 - Sequence 413858 from Patent EP1572962. JD209571 - Sequence 190595 from Patent EP1572962. JD128545 - Sequence 109569 from Patent EP1572962. JD534741 - Sequence 515765 from Patent EP1572962. JD366237 - Sequence 347261 from Patent EP1572962. JD212425 - Sequence 193449 from Patent EP1572962. JD286811 - Sequence 267835 from Patent EP1572962. JD286813 - Sequence 267837 from Patent EP1572962. JD286815 - Sequence 267839 from Patent EP1572962. JD511602 - Sequence 492626 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q9BYT8 (Reactome details) participates in the following event(s): R-HSA-8940959 Neurolysin degrades neurotensin R-HSA-375276 Peptide ligand-binding receptors R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-500792 GPCR ligand binding R-HSA-372790 Signaling by GPCR R-HSA-162582 Signal Transduction

Other Names for This Gene


	Alternate Gene Symbols: AGTBP, ENST00000380985.1, ENST00000380985.2, ENST00000380985.3, ENST00000380985.4, ENST00000380985.5, ENST00000380985.6, ENST00000380985.7, ENST00000380985.8, ENST00000380985.9, KIAA1226, NEUL_HUMAN, NM_020726, Q9BYT8, Q9ULJ4, uc318pyq.1, uc318pyq.2 UCSC ID: ENST00000380985.10_4 RefSeq Accession: NM_020726.5 Protein: Q9BYT8 (aka NEUL_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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