ID:NDK7_HUMAN DESCRIPTION: RecName: Full=Nucleoside diphosphate kinase 7; Short=NDK 7; Short=NDP kinase 7; EC=2.7.4.6; AltName: Full=nm23-H7; FUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. CATALYTIC ACTIVITY: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. COFACTOR: Magnesium (By similarity). SIMILARITY: Belongs to the NDK family. SIMILARITY: Contains 1 DM10 domain.
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
MalaCards Disease Associations
MalaCards Gene Search: NME7 Diseases sorted by gene-association score: dextrocardia with situs inversus* (247) * = Manually curated disease association
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y5B8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF205430 - JP 2014500723-A/12933: Polycomb-Associated Non-Coding RNAs. LF383654 - JP 2014500723-A/191157: Polycomb-Associated Non-Coding RNAs. AF153191 - Homo sapiens nm23-H7 (NME7) mRNA, complete cds. BC006983 - Homo sapiens non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase), mRNA (cDNA clone MGC:12203 IMAGE:3997152), complete cds. AK290701 - Homo sapiens cDNA FLJ76131 complete cds, highly similar to Homo sapiens non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase) (NME7), transcript variant 1, mRNA. AK094513 - Homo sapiens cDNA FLJ37194 fis, clone BRALZ2005467, highly similar to Nucleoside diphosphate kinase 7 (EC 2.7.4.6). AK301917 - Homo sapiens cDNA FLJ58336 complete cds, highly similar to Nucleoside diphosphate kinase 7 (EC 2.7.4.6). KJ905462 - Synthetic construct Homo sapiens clone ccsbBroadEn_15052 NME7 gene, encodes complete protein. AB463934 - Synthetic construct DNA, clone: pF1KB8210, Homo sapiens NME7 gene for non-metastatic cells 7, protein expressed in, without stop codon, in Flexi system. MA619231 - JP 2018138019-A/191157: Polycomb-Associated Non-Coding RNAs. MA441007 - JP 2018138019-A/12933: Polycomb-Associated Non-Coding RNAs. JD524193 - Sequence 505217 from Patent EP1572962. LF320432 - JP 2014500723-A/127935: Polycomb-Associated Non-Coding RNAs. JD374656 - Sequence 355680 from Patent EP1572962. LF320419 - JP 2014500723-A/127922: Polycomb-Associated Non-Coding RNAs. LF320416 - JP 2014500723-A/127919: Polycomb-Associated Non-Coding RNAs. MA556009 - JP 2018138019-A/127935: Polycomb-Associated Non-Coding RNAs. MA555996 - JP 2018138019-A/127922: Polycomb-Associated Non-Coding RNAs. MA555993 - JP 2018138019-A/127919: Polycomb-Associated Non-Coding RNAs. AB209049 - Homo sapiens mRNA for nucleoside-diphosphate kinase 7 isoform a variant protein. LF320411 - JP 2014500723-A/127914: Polycomb-Associated Non-Coding RNAs. LF320408 - JP 2014500723-A/127911: Polycomb-Associated Non-Coding RNAs. LF320407 - JP 2014500723-A/127910: Polycomb-Associated Non-Coding RNAs. LF320406 - JP 2014500723-A/127909: Polycomb-Associated Non-Coding RNAs. MA555988 - JP 2018138019-A/127914: Polycomb-Associated Non-Coding RNAs. MA555985 - JP 2018138019-A/127911: Polycomb-Associated Non-Coding RNAs. MA555984 - JP 2018138019-A/127910: Polycomb-Associated Non-Coding RNAs. MA555983 - JP 2018138019-A/127909: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-7176 - UTP and CTP de novo biosynthesis PWY-7184 - pyrimidine deoxyribonucleotides de novo biosynthesis PWY-7197 - pyrimidine deoxyribonucleotide phosphorylation PWY-7200 - superpathway of pyrimidine deoxyribonucleoside salvage PWY-7205 - CMP phosphorylation PWY-7210 - pyrimidine deoxyribonucleotides biosynthesis from CTP PWY-7211 - superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis PWY-7221 - guanosine ribonucleotides de novo biosynthesis PWY-7224 - purine deoxyribonucleosides salvage PWY-7226 - guanosine deoxyribonucleotides de novo biosynthesis PWY-7227 - adenosine deoxyribonucleotides de novo biosynthesis PWY-7228 - guanosine nucleotides de novo biosynthesis PWY-841 - purine nucleotides de novo biosynthesis PWY0-162 - superpathway of pyrimidine ribonucleotides de novo biosynthesis PWY66-409 - superpathway of purine nucleotide salvage
Reactome (by CSHL, EBI, and GO)
Protein Q9Y5B8 (Reactome details) participates in the following event(s):
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
