Human Gene NMT1 (ENST00000258960.7_9) from GENCODE V47lift37

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Description: N-myristoyltransferase 1 (from RefSeq NM_021079.5)
Gencode Transcript: ENST00000258960.7_9
Gencode Gene: ENSG00000136448.13_16
Transcript (Including UTRs)
Position: hg19 chr17:43,138,685-43,186,384 Size: 47,700 Total Exon Count: 12 Strand: +
Coding Region
Position: hg19 chr17:43,138,698-43,183,007 Size: 44,310 Coding Exon Count: 12

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr17:43,138,685-43,186,384)			mRNA (may differ from genome)		Protein (496 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Malacards	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: NMT1_HUMAN DESCRIPTION: RecName: Full=Glycylpeptide N-tetradecanoyltransferase 1; EC=2.3.1.97; AltName: Full=Myristoyl-CoA:protein N-myristoyltransferase 1; Short=NMT 1; Short=Type I N-myristoyltransferase; AltName: Full=Peptide N-myristoyltransferase 1; FUNCTION: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. CATALYTIC ACTIVITY: Tetradecanoyl-CoA + glycylpeptide = CoA + N- tetradecanoylglycylpeptide. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Heart, gut, kidney, liver and placenta. SIMILARITY: Belongs to the NMT family. SEQUENCE CAUTION: Sequence=AAC09294.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: NMT1 Diseases sorted by gene-association score: gallbladder cancer (4)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C030370 2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone D000082 Acetaminophen D000643 Ammonium Chloride D001564 Benzo(a)pyrene D003300 Copper D003375 Coumestrol D003993 Dibutyl Phthalate D004237 Diuron D004958 Estradiol D019833 Genistein more ... click here to view the complete list

Common Gene Haplotype Alleles


	Press "+" in the title bar above to open this section.

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 43.73 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 864.25 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


	Press "+" in the title bar above to open this section.

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
3' UTR	-1260.40	3377	-0.373	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR016181 - Acyl_CoA_acyltransferase
IPR000903 - MyristoylCoA_TrFase
IPR022677 - MyristoylCoA_TrFase_C
IPR022678 - MyristoylCoA_TrFase_CS
IPR022676 - MyristoylCoA_TrFase_N

Pfam Domains:
PF01233 - Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
PF02799 - Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

SCOP Domains:
55729 - Acyl-CoA N-acyltransferases (Nat)

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1RXT - X-ray MuPIT

3IU1 - X-ray MuPIT

3IU2 - X-ray MuPIT

3IWE - X-ray MuPIT

3JTK - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on P30419


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser
Gene Details	Gene Details				Gene Details
Gene Sorter	Gene Sorter				Gene Sorter
	RGD	Ensembl			SGD
					Protein Sequence
					Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0004379 glycylpeptide N-tetradecanoyltransferase activity GO:0016740 transferase activity GO:0016746 transferase activity, transferring acyl groups GO:0019107 myristoyltransferase activity Biological Process: GO:0001701 in utero embryonic development GO:0006499 N-terminal protein myristoylation GO:0018008 N-terminal peptidyl-glycine N-myristoylation GO:0022400 regulation of rhodopsin mediated signaling pathway GO:0042180 cellular ketone metabolic process GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Cellular Component: GO:0005737 cytoplasm GO:0005739 mitochondrion GO:0005829 cytosol GO:0005886 plasma membrane GO:0016020 membrane GO:0019898 extrinsic component of membrane

Descriptions from all associated GenBank mRNAs


	Y17208 - Homo sapiens mRNA for myristoyl-CoA:protein N-myristoyltransferase, long form. Y17209 - Homo sapiens mRNA for myristoyl-CoA:protein N-myristoyltransferase, short form. BC006538 - Homo sapiens N-myristoyltransferase 1, mRNA (cDNA clone MGC:2018 IMAGE:3009814), complete cds. BC006569 - Homo sapiens N-myristoyltransferase 1, mRNA (cDNA clone MGC:3820 IMAGE:3009814), complete cds. AK303517 - Homo sapiens cDNA FLJ54222 complete cds, highly similar to Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97). AK291936 - Homo sapiens cDNA FLJ76905 complete cds, highly similar to Homo sapiens N-myristoyltransferase 1 (NMT1), mRNA. AF043324 - Homo sapiens N-myristoyltransferase 1 mRNA, complete cds. AB527516 - Synthetic construct DNA, clone: pF1KB5880, Homo sapiens NMT1 gene for N-myristoyltransferase 1, without stop codon, in Flexi system. KJ891708 - Synthetic construct Homo sapiens clone ccsbBroadEn_01102 NMT1 gene, encodes complete protein. BC008579 - Homo sapiens N-myristoyltransferase 1, mRNA (cDNA clone IMAGE:4178079), partial cds. AF020500 - Homo sapiens myristoyl CoA:protein N-myristoyltransferase mRNA, complete cds. BC007258 - Homo sapiens N-myristoyltransferase 1, mRNA (cDNA clone IMAGE:3050227), partial cds. BC008312 - Homo sapiens N-myristoyltransferase 1, mRNA (cDNA clone IMAGE:3050226), partial cds. M86707 - Homo sapiens myristoyl CoA:protein N-myristoyltransferase mRNA. BC109226 - Homo sapiens N-myristoyltransferase 1, mRNA (cDNA clone IMAGE:40009850), partial cds. JD361850 - Sequence 342874 from Patent EP1572962. JD053255 - Sequence 34279 from Patent EP1572962. JD543990 - Sequence 525014 from Patent EP1572962. JD356069 - Sequence 337093 from Patent EP1572962. JD526551 - Sequence 507575 from Patent EP1572962. JD253745 - Sequence 234769 from Patent EP1572962. JD394126 - Sequence 375150 from Patent EP1572962. JD276606 - Sequence 257630 from Patent EP1572962. JD470926 - Sequence 451950 from Patent EP1572962. JD154177 - Sequence 135201 from Patent EP1572962. JD539911 - Sequence 520935 from Patent EP1572962. JD302392 - Sequence 283416 from Patent EP1572962. JD552918 - Sequence 533942 from Patent EP1572962. JD426440 - Sequence 407464 from Patent EP1572962. JD498704 - Sequence 479728 from Patent EP1572962. JD155574 - Sequence 136598 from Patent EP1572962. JD142791 - Sequence 123815 from Patent EP1572962. JD278557 - Sequence 259581 from Patent EP1572962. JD528891 - Sequence 509915 from Patent EP1572962. JD559274 - Sequence 540298 from Patent EP1572962. JD417086 - Sequence 398110 from Patent EP1572962. JD317853 - Sequence 298877 from Patent EP1572962. JD469516 - Sequence 450540 from Patent EP1572962. JD075486 - Sequence 56510 from Patent EP1572962. JD232093 - Sequence 213117 from Patent EP1572962. JD235500 - Sequence 216524 from Patent EP1572962. JD257444 - Sequence 238468 from Patent EP1572962. JD208082 - Sequence 189106 from Patent EP1572962. JD428169 - Sequence 409193 from Patent EP1572962. JD277249 - Sequence 258273 from Patent EP1572962. JD121349 - Sequence 102373 from Patent EP1572962. JD097996 - Sequence 79020 from Patent EP1572962. JD109622 - Sequence 90646 from Patent EP1572962. JD292341 - Sequence 273365 from Patent EP1572962. JD382693 - Sequence 363717 from Patent EP1572962. U79285 - Human clone 23828 mRNA sequence. JD519917 - Sequence 500941 from Patent EP1572962. JD146483 - Sequence 127507 from Patent EP1572962. JD528107 - Sequence 509131 from Patent EP1572962. JD500892 - Sequence 481916 from Patent EP1572962. JD431157 - Sequence 412181 from Patent EP1572962. JD500872 - Sequence 481896 from Patent EP1572962. JD369426 - Sequence 350450 from Patent EP1572962. JD387276 - Sequence 368300 from Patent EP1572962. JD126733 - Sequence 107757 from Patent EP1572962. JD131574 - Sequence 112598 from Patent EP1572962. JD435575 - Sequence 416599 from Patent EP1572962. JD122248 - Sequence 103272 from Patent EP1572962. JD415753 - Sequence 396777 from Patent EP1572962. JD194225 - Sequence 175249 from Patent EP1572962. JD122284 - Sequence 103308 from Patent EP1572962. JD385029 - Sequence 366053 from Patent EP1572962. JD518801 - Sequence 499825 from Patent EP1572962. JD080517 - Sequence 61541 from Patent EP1572962. JD429844 - Sequence 410868 from Patent EP1572962. JD439138 - Sequence 420162 from Patent EP1572962. JD095698 - Sequence 76722 from Patent EP1572962. JD187913 - Sequence 168937 from Patent EP1572962. JD185528 - Sequence 166552 from Patent EP1572962. JD367071 - Sequence 348095 from Patent EP1572962. JD340346 - Sequence 321370 from Patent EP1572962. JD144108 - Sequence 125132 from Patent EP1572962. JD541646 - Sequence 522670 from Patent EP1572962. JD471071 - Sequence 452095 from Patent EP1572962. JD471120 - Sequence 452144 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein P30419 (Reactome details) participates in the following event(s): R-HSA-141367 Myristoylation of tBID by NMT1 R-HSA-162914 Myristoylation of Nef R-HSA-2534087 NMT1/2 transfer MYS to GNAT1 R-HSA-75108 Activation, myristolyation of BID and translocation to mitochondria R-HSA-162599 Late Phase of HIV Life Cycle R-HSA-109606 Intrinsic Pathway for Apoptosis R-HSA-162587 HIV Life Cycle R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade R-HSA-109581 Apoptosis R-HSA-162906 HIV Infection R-HSA-2514856 The phototransduction cascade R-HSA-5357801 Programmed Cell Death R-HSA-5663205 Infectious disease R-HSA-2187338 Visual phototransduction R-HSA-1643685 Disease R-HSA-418594 G alpha (i) signalling events R-HSA-388396 GPCR downstream signalling R-HSA-372790 Signaling by GPCR R-HSA-162582 Signal Transduction

Other Names for This Gene


	Alternate Gene Symbols: A8K7C1, ENST00000258960.1, ENST00000258960.2, ENST00000258960.3, ENST00000258960.4, ENST00000258960.5, ENST00000258960.6, NMT , NMT1 , NMT1_HUMAN, NM_021079, P30419, Q9UE09, uc317ger.1, uc317ger.2 UCSC ID: ENST00000258960.7_9 RefSeq Accession: NM_021079.5 Protein: P30419 (aka NMT1_HUMAN)

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.