Human Gene NMUR1 (ENST00000305141.5_7) from GENCODE V47lift37
  Description: neuromedin U receptor 1 (from RefSeq NM_006056.5)
Gencode Transcript: ENST00000305141.5_7
Gencode Gene: ENSG00000171596.7_9
Transcript (Including UTRs)
   Position: hg19 chr2:232,387,898-232,395,156 Size: 7,259 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr2:232,389,754-232,395,072 Size: 5,319 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:232,387,898-232,395,156)mRNA (may differ from genome)Protein (426 aa)
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HGNCMGIOMIMPubMedReactomeUniProtKB
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-  Comments and Description Text from UniProtKB
  ID: NMUR1_HUMAN
DESCRIPTION: RecName: Full=Neuromedin-U receptor 1; Short=NMU-R1; AltName: Full=G-protein coupled receptor 66; AltName: Full=G-protein coupled receptor FM-3;
FUNCTION: Receptor for the neuromedin-U and neuromedin-S neuropeptides (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in greatest abundance in peripheral organs, particularly in elements of the gastrointestinal and urogenital systems with highest levels in testes. In central nervous system structures express levels are much lower than those seen in peripheral organs. Within the CNS, has been detected in highest abundance in the cerebellum, dorsal root ganglia, hippocampus, and spinal cord.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CAUTION: It is uncertain whether Met-1 or Met-24 is the initiator.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.73 RPKM in Spleen
Total median expression: 32.24 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -34.5084-0.411 Picture PostScript Text
3' UTR -631.301856-0.340 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR005390 - NeuromedU_rcpt
IPR005391 - NeuromedU_rcpt_1

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx
PF10324 - Serpentine type 7TM GPCR chemoreceptor Srw
PF13853 - Olfactory receptor

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q9HB89
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001607 neuromedin U receptor activity
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0008188 neuropeptide receptor activity
GO:0042924 neuromedin U binding

Biological Process:
GO:0006816 calcium ion transport
GO:0006821 chloride transport
GO:0006939 smooth muscle contraction
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007218 neuropeptide signaling pathway
GO:0019722 calcium-mediated signaling
GO:0048016 inositol phosphate-mediated signaling

Cellular Component:
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC036543 - Homo sapiens neuromedin U receptor 1, mRNA (cDNA clone MGC:41854 IMAGE:5265972), complete cds.
BC051914 - Homo sapiens neuromedin U receptor 1, mRNA (cDNA clone MGC:60397 IMAGE:6194542), complete cds.
AK300222 - Homo sapiens cDNA FLJ60151 complete cds, highly similar to Neuromedin U receptor 1.
AK301102 - Homo sapiens cDNA FLJ56741 complete cds, highly similar to Neuromedin U receptor 1.
AF272362 - Homo sapiens neuromedin U receptor 1 (NMUR1) mRNA, complete cds.
KJ898191 - Synthetic construct Homo sapiens clone ccsbBroadEn_07585 NMUR1 gene, encodes complete protein.
AB528917 - Synthetic construct DNA, clone: pF1KE0707, Homo sapiens NMUR1 gene for neuromedin U receptor 1, without stop codon, in Flexi system.
JD301806 - Sequence 282830 from Patent EP1572962.
JD267185 - Sequence 248209 from Patent EP1572962.
JD148200 - Sequence 129224 from Patent EP1572962.
JD519625 - Sequence 500649 from Patent EP1572962.
JD079940 - Sequence 60964 from Patent EP1572962.
JD080851 - Sequence 61875 from Patent EP1572962.
JD412567 - Sequence 393591 from Patent EP1572962.
JD378137 - Sequence 359161 from Patent EP1572962.
JD124196 - Sequence 105220 from Patent EP1572962.
JD172909 - Sequence 153933 from Patent EP1572962.
JD489574 - Sequence 470598 from Patent EP1572962.
JD298203 - Sequence 279227 from Patent EP1572962.
JD106820 - Sequence 87844 from Patent EP1572962.
JD505239 - Sequence 486263 from Patent EP1572962.
JD414718 - Sequence 395742 from Patent EP1572962.
JD397018 - Sequence 378042 from Patent EP1572962.
JD476686 - Sequence 457710 from Patent EP1572962.
JD143861 - Sequence 124885 from Patent EP1572962.
JD506179 - Sequence 487203 from Patent EP1572962.
JD321944 - Sequence 302968 from Patent EP1572962.
JD565583 - Sequence 546607 from Patent EP1572962.
JD300910 - Sequence 281934 from Patent EP1572962.
JD513812 - Sequence 494836 from Patent EP1572962.
JD482170 - Sequence 463194 from Patent EP1572962.
JD499987 - Sequence 481011 from Patent EP1572962.
JD549686 - Sequence 530710 from Patent EP1572962.
JD467944 - Sequence 448968 from Patent EP1572962.
CU691372 - Synthetic construct Homo sapiens gateway clone IMAGE:100020895 5' read NMUR1 mRNA.
CU690888 - Synthetic construct Homo sapiens gateway clone IMAGE:100021352 5' read NMUR1 mRNA.
JD407118 - Sequence 388142 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9HB89 (Reactome details) participates in the following event(s):

R-HSA-964800 Neuromedin-U receptors bind neuromedins U, S
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-416476 G alpha (q) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000305141.1, ENST00000305141.2, ENST00000305141.3, ENST00000305141.4, GPR66, NMUR1_HUMAN, NM_006056, O43664, Q7LDP6, Q8NE20, Q9HB89, uc317now.1, uc317now.2
UCSC ID: ENST00000305141.5_7
RefSeq Accession: NM_006056.5
Protein: Q9HB89 (aka NMUR1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.