ID:NNMT_HUMAN DESCRIPTION: RecName: Full=Nicotinamide N-methyltransferase; EC=2.1.1.1; FUNCTION: Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds. CATALYTIC ACTIVITY: S-adenosyl-L-methionine + nicotinamide = S- adenosyl-L-homocysteine + 1-methylnicotinamide. SUBUNIT: Monomer. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas. SIMILARITY: Belongs to the NNMT/PNMT/TEMT family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P40261
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0010243 response to organonitrogen compound GO:0031100 animal organ regeneration GO:0032259 methylation GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway GO:0042493 response to drug
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
