Human Gene NOC4L (ENST00000330579.6_4) from GENCODE V47lift37
  Description: Q9BVI4; O14503: BHLHE40; NbExp=3; IntAct=EBI-395927, EBI-711810; Q9BVI4; Q96EY1-2: DNAJA3; NbExp=3; IntAct=EBI-395927, EBI-3952284; Q9BVI4; Q68J44: DUSP29; NbExp=3; IntAct=EBI-395927, EBI-1054321; Q9BVI4; Q7L775: EPM2AIP1; NbExp=3; IntAct=EBI-395927, EBI-6255981; Q9BVI4; Q13422: IKZF1; NbExp=3; IntAct=EBI-395927, EBI-745305; Q9BVI4; P19012: KRT15; NbExp=4; IntAct=EBI-395927, EBI-739566; Q9BVI4; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-395927, EBI-12805508; Q9BVI4; Q9C0E8-2: LNPK; NbExp=3; IntAct=EBI-395927, EBI-11024283; Q9BVI4; Q8TDS5: OXER1; NbExp=3; IntAct=EBI-395927, EBI-12813389; Q9BVI4; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-395927, EBI-79165; Q9BVI4; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-395927, EBI-947187; Q9BVI4; Q8N6Y0: USHBP1; NbExp=2; IntAct=EBI-395927, EBI-739895; Q9BVI4; B2RXF5: ZBTB42; NbExp=3; IntAct=EBI-395927, EBI-12287587; (from UniProt Q9BVI4)
Gencode Transcript: ENST00000330579.6_4
Gencode Gene: ENSG00000184967.7_7
Transcript (Including UTRs)
   Position: hg19 chr12:132,629,002-132,637,013 Size: 8,012 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg19 chr12:132,629,034-132,636,946 Size: 7,913 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:132,629,002-132,637,013)mRNA (may differ from genome)Protein (516 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsHGNC
MGIPubMedReactomeUniProtKB

-  Comments and Description Text from UniProtKB
  ID: NOC4L_HUMAN
DESCRIPTION: RecName: Full=Nucleolar complex protein 4 homolog; Short=NOC4 protein homolog; AltName: Full=NOC4-like protein; AltName: Full=Nucleolar complex-associated protein 4-like protein;
INTERACTION: Q8N6Y0:USHBP1; NbExp=2; IntAct=EBI-395927, EBI-739895;
SUBCELLULAR LOCATION: Nucleus membrane; Multi-pass membrane protein. Nucleus, nucleolus.
SIMILARITY: Belongs to the CBF/MAK21 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 37.13 RPKM in Testis
Total median expression: 464.07 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -9.5032-0.297 Picture PostScript Text
3' UTR -16.5067-0.246 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR005612 - CCAAT-binding_factor

Pfam Domains:
PF03914 - CBF/Mak21 family

SCOP Domains:
48371 - ARM repeat

ModBase Predicted Comparative 3D Structure on Q9BVI4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsembl WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding

Biological Process:
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006364 rRNA processing
GO:0042254 ribosome biogenesis

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030692 Noc4p-Nop14p complex
GO:0031965 nuclear membrane
GO:0032040 small-subunit processome


-  Descriptions from all associated GenBank mRNAs
  BC001191 - Homo sapiens nucleolar complex associated 4 homolog (S. cerevisiae), mRNA (cDNA clone MGC:3162 IMAGE:3354945), complete cds.
AK074489 - Homo sapiens cDNA FLJ90008 fis, clone HEMBA1000275.
BC071958 - Homo sapiens nucleolar complex associated 4 homolog (S. cerevisiae), mRNA (cDNA clone MGC:88650 IMAGE:6597539), complete cds.
CU687200 - Synthetic construct Homo sapiens gateway clone IMAGE:100023150 5' read NOC4L mRNA.
DQ892518 - Synthetic construct clone IMAGE:100005148; FLH187097.01X; RZPDo839D0972D nucleolar complex associated 4 homolog (S. cerevisiae) (NOC4L) gene, encodes complete protein.
DQ895730 - Synthetic construct Homo sapiens clone IMAGE:100010190; FLH187093.01L; RZPDo839D0962D nucleolar complex associated 4 homolog (S. cerevisiae) (NOC4L) gene, encodes complete protein.
BC007893 - Homo sapiens nucleolar complex associated 4 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:4126019), partial cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9BVI4 (Reactome details) participates in the following event(s):

R-HSA-6790906 EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-8868773 rRNA processing in the nucleus and cytosol
R-HSA-72312 rRNA processing
R-HSA-8953854 Metabolism of RNA

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000330579.1, ENST00000330579.2, ENST00000330579.3, ENST00000330579.4, ENST00000330579.5, NOC4L_HUMAN, NR_183060, Q8N2S5, Q96I14, Q9BVI4, uc317szx.1, uc317szx.2
UCSC ID: ENST00000330579.6_4
RefSeq Accession: NM_024078.3
Protein: Q9BVI4 (aka NOC4L_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.