Human Gene NOL7 (ENST00000451315.7_4) from GENCODE V47lift37

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Description: nucleolar protein 7, transcript variant 1 (from RefSeq NM_016167.5)
Gencode Transcript: ENST00000451315.7_4
Gencode Gene: ENSG00000225921.7_7
Transcript (Including UTRs)
Position: hg19 chr6:13,615,567-13,621,944 Size: 6,378 Total Exon Count: 8 Strand: +
Coding Region
Position: hg19 chr6:13,615,591-13,621,059 Size: 5,469 Coding Exon Count: 8

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr6:13,615,567-13,621,944)			mRNA (may differ from genome)		Protein (257 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: NOL7_HUMAN DESCRIPTION: RecName: Full=Nucleolar protein 7; AltName: Full=Nucleolar protein of 27 kDa; SUBCELLULAR LOCATION: Nucleus, nucleolus. TISSUE SPECIFICITY: Expressed in numerous tissues. Particularly prevalent in the adrenal gland, thyroid gland, heart and skeletal muscle. SEQUENCE CAUTION: Sequence=CAB43398.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=CAI19840.1; Type=Erroneous gene model prediction;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D016572 Cyclosporine D000082 Acetaminophen D001564 Benzo(a)pyrene D002994 Clofibrate D019327 Copper Sulfate D003993 Dibutyl Phthalate D004026 Dieldrin D004997 Ethinyl Estradiol D005839 Gentamicins D006861 Hydrogen Peroxide more ... click here to view the complete list

Common Gene Haplotype Alleles


	Press "+" in the title bar above to open this section.

Microarray Expression Data


	Press "+" in the title bar above to open this section.

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-7.00	24	-0.292	Picture	PostScript	Text
3' UTR	-179.40	885	-0.203	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR012579 - NUC129

Pfam Domains:
PF08157 - NUC129 domain

ModBase Predicted Comparative 3D Structure on Q9UMY1


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003723 RNA binding Cellular Component: GO:0005634 nucleus GO:0005730 nucleolus GO:0005739 mitochondrion

Descriptions from all associated GenBank mRNAs


	LF385497 - JP 2014500723-A/193000: Polycomb-Associated Non-Coding RNAs. MA621074 - JP 2018138019-A/193000: Polycomb-Associated Non-Coding RNAs. AF172066 - Homo sapiens 27 kDa nucleolar protein (NOL7) mRNA, complete cds. LF209767 - JP 2014500723-A/17270: Polycomb-Associated Non-Coding RNAs. BC062683 - Homo sapiens nucleolar protein 7, 27kDa, mRNA (cDNA clone MGC:71933 IMAGE:6499123), complete cds. LF209768 - JP 2014500723-A/17271: Polycomb-Associated Non-Coding RNAs. AK075301 - Homo sapiens cDNA FLJ90820 fis, clone Y79AA1001272. BC023517 - Homo sapiens nucleolar protein 7, 27kDa, mRNA (cDNA clone MGC:12551 IMAGE:4298095), complete cds. CU692792 - Synthetic construct Homo sapiens gateway clone IMAGE:100022412 5' read NOL7 mRNA. HQ447631 - Synthetic construct Homo sapiens clone IMAGE:100070977; CCSB013443_01 nucleolar protein 7, 27kDa (NOL7) gene, encodes complete protein. KJ893907 - Synthetic construct Homo sapiens clone ccsbBroadEn_03301 NOL7 gene, encodes complete protein. AL050299 - Homo sapiens mRNA; cDNA DKFZp566B153 (from clone DKFZp566B153); partial cds. LF331564 - JP 2014500723-A/139067: Polycomb-Associated Non-Coding RNAs. LF331565 - JP 2014500723-A/139068: Polycomb-Associated Non-Coding RNAs. LF331566 - JP 2014500723-A/139069: Polycomb-Associated Non-Coding RNAs. LF331567 - JP 2014500723-A/139070: Polycomb-Associated Non-Coding RNAs. MA567141 - JP 2018138019-A/139067: Polycomb-Associated Non-Coding RNAs. MA567142 - JP 2018138019-A/139068: Polycomb-Associated Non-Coding RNAs. MA567143 - JP 2018138019-A/139069: Polycomb-Associated Non-Coding RNAs. MA567144 - JP 2018138019-A/139070: Polycomb-Associated Non-Coding RNAs. MA445344 - JP 2018138019-A/17270: Polycomb-Associated Non-Coding RNAs. MA445345 - JP 2018138019-A/17271: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: C6orf90, ENST00000451315.1, ENST00000451315.2, ENST00000451315.3, ENST00000451315.4, ENST00000451315.5, ENST00000451315.6, NM_016167, NOL7 , NOL7_HUMAN, NOP27, Q5T297, Q9UMY1, Q9Y3U7, uc320srt.1, uc320srt.2 UCSC ID: ENST00000451315.7_4 RefSeq Accession: NM_016167.5 Protein: Q9UMY1 (aka NOL7_HUMAN)

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.