ID:NOP2_HUMAN DESCRIPTION: RecName: Full=Putative ribosomal RNA methyltransferase NOP2; EC=2.1.1.-; AltName: Full=Nucleolar protein 1; AltName: Full=Nucleolar protein 2 homolog; AltName: Full=Proliferating-cell nucleolar antigen p120; AltName: Full=Proliferation-associated nucleolar protein p120; FUNCTION: May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase. SUBUNIT: Interaction with MCRS1. SUBCELLULAR LOCATION: Nucleus, nucleolus. DEVELOPMENTAL STAGE: Expressed in G1 and peaks during the early S phase of the cell cycle. SIMILARITY: Belongs to the methyltransferase superfamily. RsmB/NOP family. SEQUENCE CAUTION: Sequence=AAA36398.1; Type=Frameshift; Positions=780; Sequence=CAA39119.1; Type=Frameshift; Positions=780;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P46087
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000027 ribosomal large subunit assembly GO:0000470 maturation of LSU-rRNA GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006364 rRNA processing GO:0008284 positive regulation of cell proliferation GO:0032259 methylation GO:0042254 ribosome biogenesis GO:0070475 rRNA base methylation GO:1901796 regulation of signal transduction by p53 class mediator
X55504 - H.sapiens mRNA for P120 antigen. M32110 - Human proliferating-cell nucleolar protein P120 mRNA, complete cds. BC000656 - Homo sapiens NOP2 nucleolar protein homolog (yeast), mRNA (cDNA clone MGC:3093 IMAGE:3349415), complete cds. BC065257 - Homo sapiens NOP2 nucleolar protein homolog (yeast), mRNA (cDNA clone MGC:75077 IMAGE:6146884), complete cds. AK129852 - Homo sapiens cDNA FLJ26342 fis, clone HRT03289, highly similar to Proliferating-cell nucleolar antigen P120. BC106072 - Homo sapiens NOP2 nucleolar protein homolog (yeast), mRNA (cDNA clone MGC:117384 IMAGE:6169852), complete cds. BC082985 - Homo sapiens NOP2 nucleolar protein homolog (yeast), mRNA (cDNA clone MGC:99650 IMAGE:6672391), complete cds. AK056208 - Homo sapiens cDNA FLJ31646 fis, clone NT2RI2003921, highly similar to PROLIFERATING-CELL NUCLEOLAR ANTIGEN P120. AK307582 - Homo sapiens cDNA, FLJ97530. BC128183 - Homo sapiens NOP2 nucleolar protein homolog (yeast), mRNA (cDNA clone MGC:149287 IMAGE:40113364), complete cds. BC128184 - Homo sapiens NOP2 nucleolar protein homolog (yeast), mRNA (cDNA clone MGC:149288 IMAGE:40113367), complete cds. KJ905839 - Synthetic construct Homo sapiens clone ccsbBroadEn_15509 NOP2 gene, encodes complete protein. KJ901605 - Synthetic construct Homo sapiens clone ccsbBroadEn_10999 NOP2 gene, encodes complete protein.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P46087 (Reactome details) participates in the following event(s):
R-HSA-6790944 NOP2 (NSUN1) methylates cytidine-4447 of 28S rRNA yielding 5-methylcytidine-4447 R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-6790901 rRNA modification in the nucleus and cytosol R-HSA-212436 Generic Transcription Pathway R-HSA-8868773 rRNA processing in the nucleus and cytosol R-HSA-73857 RNA Polymerase II Transcription R-HSA-72312 rRNA processing R-HSA-74160 Gene expression (Transcription) R-HSA-8953854 Metabolism of RNA
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
