Human Gene NOS2 (ENST00000313735.11_10) from GENCODE V47lift37
Description: nitric oxide synthase 2 (from RefSeq NM_000625.4)
Gencode Transcript: ENST00000313735.11_10
Gencode Gene: ENSG00000007171.19_15
Transcript (Including UTRs)
Position: hg19 chr17:26,083,792-26,127,555 Size: 43,764 Total Exon Count: 27 Strand: -
Coding Region
Position: hg19 chr17:26,084,272-26,125,835 Size: 41,564 Coding Exon Count: 26
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: NOS2_HUMAN
DESCRIPTION: RecName: Full=Nitric oxide synthase, inducible; EC=1.14.13.39; AltName: Full=Hepatocyte NOS; Short=HEP-NOS; AltName: Full=Inducible NO synthase; Short=Inducible NOS; Short=iNOS; AltName: Full=NOS type II; AltName: Full=Peptidyl-cysteine S-nitrosylase NOS2;
FUNCTION: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.CATALYTIC ACTIVITY: 2 L-arginine + 3 NADPH + 4 O(2) = 2 L- citrulline + 2 nitric oxide + 3 NADP(+) + 4 H(2)O.COFACTOR: Heme group (By similarity).COFACTOR: Binds 1 FAD (By similarity).COFACTOR: Binds 1 FMN (By similarity).COFACTOR: Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme (By similarity).ENZYME REGULATION: Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity (By similarity).SUBUNIT: Homodimer. Binds SLC9A3R1.TISSUE SPECIFICITY: Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.INDUCTION: By endotoxins and cytokines. Induced by IFNG/IFN-gamma acting synergistically with bacterial lipopolysaccharides (LPS), TNF or IL1B/interleukin-1 beta.POLYMORPHISM: Note=Genetic variations in NOS2 are involved in resistance to malaria [MIM:611162] .SIMILARITY: Belongs to the NOS family.SIMILARITY: Contains 1 FAD-binding FR-type domain.SIMILARITY: Contains 1 flavodoxin-like domain.WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/nos2a/";WEB RESOURCE: Name=Wikipedia; Note=Nitric oxide synthase entry; URL="http://en.wikipedia.org/wiki/Nitric_oxide_synthase";
Primer design for this transcript
MalaCards Disease Associations
MalaCards Gene Search: NOS2
Diseases sorted by gene-association score: malaria * (187), borderline leprosy (22), collagenous colitis (16), chlamydia (15), peyronie's disease (14), spinal cord injury (14), leishmaniasis (13), internal hemorrhoid (13), hemorrhoid (12), gastritis (12), hypertension, essential * (12), pityriasis lichenoides (10), chagas disease (9), hepatopulmonary syndrome (9), mycetoma (9), dystrophinopathies (9), myocarditis (8), cerebral artery occlusion (8), anoxia (8), nervous system disease (8), sleeping sickness (8), impotence (7), visceral leishmaniasis (7), tendinopathy (7), tympanosclerosis (7), retinal vasculitis (7), leukomalacia (7), central nervous system disease (7), crohn's colitis (7), salivary gland adenoid cystic carcinoma (6), pyosalpinx (6), diabetic cataract (6), ureteral obstruction (6), arthus reaction (6), idiopathic achalasia (6), eales disease (6), varicocele (6), enterobiasis (6), pulpitis (6), brain ischemia (6), periventricular leukomalacia (5), orthostatic intolerance (5), vertebral artery occlusion (5), ischemia (4), aortic disease (4), vascular disease (4), pulmonary hypertension (3), colitis (3), colorectal cancer (2), autoinflammation, lipodystrophy, and dermatosis syndrome (2), multiple sclerosis, disease progression, modifier of (1), diabetes mellitus, insulin-dependent (1), primary ciliary dyskinesia (1)* = Manually curated disease association
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
D008070
Lipopolysaccharides
D009569
Nitric Oxide
C004479
pimagedine
D003474
Curcumin
D004958
Estradiol
C440499
lipopolysaccharide, Escherichia coli 0111 B4
C059514
resveratrol
D003907
Dexamethasone
D004229
Dithiothreitol
D005944
Glucosamine
D008911
Minocycline
C104820
N-(3-(aminomethyl)benzyl)acetamidine
D010100
Oxygen
D011794
Quercetin
D019821
Simvastatin
C108830
Y 27632
C020972
pyrrolidine dithiocarbamic acid
C089730
rosiglitazone
C057693
troglitazone
C097240
15-deoxy-delta(12,14)-prostaglandin J2
C477819
15-deoxyprostaglandin J2
C093973
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
D000082
Acetaminophen
D000111
Acetylcysteine
D001241
Aspirin
D001564
Benzo(a)pyrene
D019256
Cadmium Chloride
D002211
Capsaicin
D002251
Carbon Tetrachloride
D002945
Cisplatin
D002994
Clofibrate
D003300
Copper
D016572
Cyclosporine
D015232
Dinoprostone
D004280
Dobutamine
D004317
Doxorubicin
D004726
Endosulfan
D000431
Ethanol
D005947
Glucose
D006851
Hydrochloric Acid
D008345
Manganese
D009020
Morphine
D009151
Mustard Gas
C496401
N-((3-(aminomethyl)phenyl)methyl)ethanimidamide
D009538
Nicotine
D009573
Nitrites
D010126
Ozone
D052638
Particulate Matter
D030421
Peroxynitrous Acid
D010656
Phenylephrine
D010936
Plant Extracts
D017382
Reactive Oxygen Species
D026423
S-Nitroso-N-Acetylpenicillamine
C027744
S-methylisothiopseudouronium
C093642
SB 203580
D016559
Tacrolimus
D013755
Tetradecanoylphorbol Acetate
D015054
Zymosan
C432165
anthra(1,9-cd)pyrazol-6(2H)-one
C072553
benzyloxycarbonylleucyl-leucyl-leucine aldehyde
C045651
epigallocatechin gallate
C020326
ferric nitrilotriacetate
C070081
fulvestrant
C482199
lipopolysaccharide, E coli O55-B5
C025340
manganese chloride
C060836
pioglitazone
C006253
pirinixic acid
C017947
sodium arsenite
C084178
telmisartan
D019813
1,2-Dimethylhydrazine
C495109
1-(beta-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetra-hydroisoquinoline
D015632
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C471009
1-naphthylethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline
D019796
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
C093124
2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine
C457499
2-chloro-5-nitrobenzanilide
C007997
25-hydroxycholesterol
C076996
27-hydroxycholesterol
C434003
3-(4-methylphenylsulfonyl)-2-propenenitrile
C090942
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole
C120076
5,11-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol
C052853
5-hydroxydecanoic acid
C003001
7-ketocholesterol
D015127
9,10-Dimethyl-1,2-benzanthracene
D000109
Acetylcholine
D000171
Acrolein
D000255
Adenosine Triphosphate
D047310
Apigenin
D017638
Asbestos, Crocidolite
D001205
Ascorbic Acid
D001397
Azoxymethane
D001514
Bee Venoms
D001761
Bleomycin
D019819
Budesonide
D019328
Buthionine Sulfoximine
D002104
Cadmium
D002117
Calcitriol
D002248
Carbon Monoxide
D002330
Carmustine
D002726
Chlorogenic Acid
D002809
Chondroitin Sulfates
D003520
Cyclophosphamide
D003634
DDT
D003609
Dactinomycin
D003676
Deferoxamine
D003975
Diazepam
D003981
Diazoxide
D004041
Dietary Fats
D004176
Dipyridamole
D004656
Enalapril
D004837
Epinephrine
D004964
Estriol
D005439
Flufenamic Acid
D005472
Fluorouracil
D005480
Flurbiprofen
C409004
GW 274150
D005688
Galactosamine
D019833
Genistein
D005839
Gentamicins
D005978
Glutathione
D006569
Hesperidin
D006632
Histamine
D006710
Homocysteine
D007052
Ibuprofen
D007213
Indomethacin
D007501
Iron
D007608
Kainic Acid
D047311
Luteolin
D008344
Maneb
C501277
Mangifera indica extract
D008550
Melatonin
D008555
Melitten
D008627
Mercuric Chloride
D008727
Methotrexate
D008798
Mevalonic Acid
D016686
Monocrotaline
C502260
N-(1-methylethyl)-1,1,2-trimethylpropylamine
C080418
N-(4-O-glycerol-3-methoxybenzyl)nonivamide
D005996
Nitroglycerin
D009599
Nitroprusside
D016566
Organoselenium Compounds
D016627
Oxidopamine
D019308
Palmitic Acid
D010269
Paraquat
D010431
Pentoxifylline
D028321
Plant Preparations
D059808
Polyphenols
D011224
Prazosin
D011374
Progesterone
D015742
Propofol
D020849
Raloxifene
D026361
Reactive Nitrogen Species
D020889
Rolipram
D012402
Rotenone
D015575
Roxithromycin
C042431
S-ethyl glutathione
D012503
Saponins
D012822
Silicon Dioxide
D012838
Silymarin
D018038
Sodium Selenite
D013311
Streptozocin
D012460
Sulfasalazine
D013629
Tamoxifen
D013739
Testosterone
D013749
Tetrachlorodibenzodioxin
D013853
Thioacetamide
D014241
Trichloroethylene
D014302
Trinitrobenzenesulfonic Acid
C113580
U 0126
D014580
Ursodeoxycholic Acid
D001335
Vehicle Emissions
D014810
Vitamin E
D015032
Zinc
C038044
baicalin
C037689
benzamide
C034786
bis(4-hydroxycinnamoyl)methane
C500927
bolinaquinone
C058636
calcitonin gene-related peptide (8-37)
C081643
candesartan
C043561
chrysin
C012843
cinnamic aldehyde
C007095
cobaltiprotoporphyrin
C018021
cobaltous chloride
C050229
demethoxycurcumin
C014476
diethyl maleate
C042986
ebselen
C005499
honokiol
C056599
icariin
C006552
kaempferol
C008261
lead acetate
C433788
lipopolysaccharide, E. coli 026-B6
C013592
mangiferin
C022838
nickel chloride
C012655
nimesulide
C102148
nitroaspirin
C095631
nitroflurbiprofen
C025589
ochratoxin A
C502617
orazipone
C029217
phenyl-N-tert-butylnitrone
C005435
phenylmethylpyrazolone
C100573
prostaglandin A1
C107773
pterostilbene
C033607
puerarin
C101426
sildenafil
C440975
silybin
C016766
sulforafan
C017953
tetramethylpyrazine
C032628
tin protoporphyrin IX
C085514
wogonin
C425062
(2-boronoethyl)-cysteine
C516138
(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine
C492909
1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane
D014013
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt
C063609
1,2-dimethyl-4-nitrobenzene
C040756
1,2-naphthoquinone
C051360
1,3-dipropyl-8-cyclopentylxanthine
C048927
1,5-anhydrofructose
C540360
1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6''-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4,-dioxin
C420084
1-(4-chlorobenzoyl)-5-methoxy-2-1H-indole-3-acetic acid 3-(nitrooxymethyl)phenyl ester
C060229
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione
D015655
1-Methyl-4-phenylpyridinium
D015058
1-Naphthylisothiocyanate
C118559
1-bromopropane
C051942
1-hexacosanol
C050175
1-hydroxy-2-naphthoic acid
C476756
10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide
D015064
16,16-Dimethylprostaglandin E2
C057916
17-hydroxyjolkinolide B
C119129
18alpha-glycyrrhetinic acid
C095284
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one
C562254
2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione
C484327
2'-benzoyloxycinnamaldehyde
D015086
2,6-Dichloroindophenol
C082313
2-(2,3-dicarboxycyclopropyl)glycine
C085911
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
D015081
2-Naphthylamine
C049584
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
C012729
2-amino-4-phosphonobutyric acid
C058394
2-chloro-N(6)cyclopentyladenosine
C031278
2-chloroethyl ethyl sulfide
C116817
2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid
C518860
2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide
C459092
2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine
C041525
3,3',4,5'-tetrahydroxystilbene
C023035
3,4,5,3',4'-pentachlorobiphenyl
C506282
3,5-dimethoxy-4'-hydroxystilbene
C524639
3,7-O-dimethylquercetin
C106592
3,9-bis((ethylthio)methyl)-K-252a
C054649
3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol
C508074
3-O-methylsphingomyelin
C041477
3-hydroxyflavone
C031136
3-methylcatechol
C047368
3-methylquercetin
C092610
3-methylsydnone-5-nitrosimine
C031285
3-xylene
C569748
4'-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol
C568824
4-((2'-O-acetylrhamnosyloxy)benzyl)isothiocyanate
C478738
4-(nitroxy)butanoic acid 4-acetylaminophenyl ester
D015112
4-Nitroquinoline-1-oxide
C400084
4-chlorobenzyltetrahydroberberine
C032171
4-coumaric acid
C418965
4-dimethylamino-3',4'-dimethoxychalcone
C027576
4-hydroxy-2-nonenal
C498826
4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide
C018599
4-methylcatechol
C003402
5,6,7,8-tetrahydrobiopterin
C080669
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one
C060298
5,7-dimethoxyflavone
C085754
5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide
C526423
5-aziridinyl-3-hydroxyl-1-methylindole-4,7-dione
C062711
5-hydroxyflavone
C058176
5-nitro-2-(3-phenylpropylamino)benzoic acid
C545140
6,8-dichloro-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine
D015121
6-Ketoprostaglandin F1 alpha
C010643
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
C121465
6-methyl-2-(phenylethynyl)pyridine
C114369
7,8-diacetoxy-4-methylcoumarin
C508169
7-(2-(4-(4-nitrobenzene)piperazinyl)ethyl)-1,3-dimethylxanthine
C502972
7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(3-piperidinyl)-1,4-dihydro-2H-pyrido(2,3-d)(1,3)oxazin-2-one
D015124
8-Bromo Cyclic Adenosine Monophosphate
C083763
8-bromoguanosino-3',5'-cyclic monophosphorothioate
C025945
8-chlorocarbochromen
C547126
AZM551248
D000079
Acetaldehyde
D019342
Acetic Acid
D020106
Acrylamide
D000244
Adenosine Diphosphate
D000395
Air Pollutants, Occupational
D000420
Albuterol
D000527
Alprostadil
D000535
Aluminum
D000577
Amides
D000620
Aminoimidazole Carboxamide
D000641
Ammonia
D000643
Ammonium Chloride
D000654
Amobarbital
D000661
Amphetamine
D000667
Ampicillin
D000841
Anisomycin
D023181
Antimicrobial Cationic Peptides
D000967
Antimony Sodium Gluconate
D001127
Arginine Vasopressin
D001151
Arsenic
D017636
Asbestos, Amphibole
D001262
Atenolol
D001285
Atropine
D001379
Azathioprine
D001554
Benzene
D001599
Berberine
D001663
Bilirubin
D001971
Bromocriptine
C469298
CEP-11004
C408982
CPG-oligonucleotide
C513821
CPU0213
C534043
CR 3294
D002110
Caffeine
D000001
Calcimycin
D002220
Carbamazepine
D012721
Carbaryl
D002351
Carrageenan
C559739
Carthamus yellow
D002392
Catechin
D017272
Celiprolol
D002599
Chalcone
D047188
Chalcones
D002713
Chlorine
D002784
Cholesterol
D002791
Cholesterol, Dietary
D060729
Coal Ash
D003035
Cobalt
D003078
Colchicine
D019327
Copper Sulfate
D006152
Cyclic GMP
D003513
Cycloheximide
D017373
Cyproterone Acetate
D003545
Cysteine
D015638
Cytochalasin D
D016207
Cytokines
D003847
Deoxyglucose
D016264
Dextran Sulfate
D003633
Dichlorodiphenyl Dichloroethylene
D004006
Dichlorvos
D004008
Diclofenac
D004052
Diethylnitrosamine
D004061
Diflunisal
D013196
Dihydrotestosterone
D004112
Dimercaprol
D004121
Dimethyl Sulfoxide
D004128
Dimethylnitrosamine
D004137
Dinitrochlorobenzene
D004147
Dioxins
D004221
Disulfiram
D004050
Ditiocarb
D016291
Dizocilpine Maleate
D004294
Domperidone
D004298
Dopamine
D004318
Doxycycline
D004365
Drugs, Chinese Herbal
D017886
Durapatite
C509867
E804 bisindole
D015118
Eicosapentaenoic Acid
D004642
Emodin
D004731
Endotoxins
D004791
Enzyme Inhibitors
D004967
Estrogens
D004976
Ethacrynic Acid
D004997
Ethinyl Estradiol
D005047
Etoposide
D005054
Eugenol
C460864
FSL-1 lipoprotein, synthetic
D011345
Fenofibrate
D018818
Fenoldopam
D005419
Flavonoids
D005473
Fluoxetine
D016666
Fluvoxamine
D005492
Folic Acid
D005557
Formaldehyde
D005632
Fructose
D062610
Fungal Polysaccharides
C120099
GW 1929
C409003
GW 273629
C453899
GW 7647
D015248
Gemfibrozil
C063170
Ginkgo biloba extract 761
D005905
Glyburide
D005999
Glycochenodeoxycholic Acid
D019695
Glycyrrhizic Acid
D006052
Gold Sodium Thiomalate
D006221
Halothane
D006418
Heme
D006427
Hemin
D006820
Hyaluronic Acid
D006854
Hydrocortisone
D006861
Hydrogen Peroxide
D047348
Hydrolyzable Tannins
D006886
Hydroxychloroquine
D007220
Industrial Waste
D007455
Iodine
D015759
Ionomycin
D007530
Isoflurane
D007545
Isoproterenol
D017879
Isothiocyanates
D007559
Ivermectin
C112524
JBT-3002
C098607
JP8 aviation fuel
C439304
KMUP 1
C487860
L-N6-(1-iminoethyl)lysine-5-tetrazole-amide
D007854
Lead
D007912
Lentinan
D007975
Leukotriene B4
D017997
Leukotriene C4
D017998
Leukotriene D4
D017706
Lisinopril
D008094
Lithium
D018021
Lithium Chloride
D019808
Losartan
D008244
Lysophosphatidylcholines
C015765
MK 473
D008274
Magnesium
D058185
Magnetite Nanoparticles
D008294
Malathion
D008315
Malondialdehyde
D008376
Maprotiline
C045153
Maxepa
D008466
Mechlorethamine
D008623
Mercaptoethanol
D008628
Mercury
D016210
Methacholine Chloride
D008694
Methamphetamine
D008713
Methimazole
D008715
Methionine
D008731
Methoxychlor
D008752
Methylene Chloride
D008767
Methylmercury Compounds
D008770
Methylnitrosourea
D008787
Metoclopramide
D008790
Metoprolol
D008795
Metronidazole
D008799
Mevinphos
D008825
Miconazole
D015735
Mifepristone
C052996
Mycoplasma arthritidis mitogen
D009183
Mycotoxins
C046808
N-benzyladriamycin-14-valerate
C497734
N1-benzyl-4-methylbenzene-1,2-diamine
C524539
NCX 6560
C405615
NS 1652
C517730
NS3728
D009271
Naltrexone
D037742
Nanotubes, Carbon
D009288
Naproxen
D009525
Niacin
D009532
Nickel
D009543
Nifedipine
D009566
Nitrates
D009578
Nitrobenzenes
D009585
Nitrogen Dioxide
D009638
Norepinephrine
C066515
O-(chloroacetylcarbamoyl)fumagillol
C474344
OMDM-1 cpd
C461399
ONO-AE1-329
C095324
ONO-NT 012
D009842
Oligopeptides
D010047
Ovalbumin
D010081
Oxazolone
C513937
PB28 compound
C113399
PD 166866
C497431
PD-0200347
C508075
Pam(3)CSK(4) peptide
D010455
Peptides
D010457
Peptidoglycan
D010575
Pesticides
D010672
Phenytoin
D010862
Pilocarpine
D020110
Pinacidil
D011070
Poly I-C
D011112
Polymyxin B
D011134
Polysaccharides
D011189
Potassium Chloride
D011190
Potassium Cyanide
D011192
Potassium Dichromate
D017035
Pravastatin
D011285
Pregnenolone Carbonitrile
D011353
Prodigiosin
D011411
Propanil
D011509
Proteoglycans
D011692
Puromycin Aminonucleoside
D011700
Putrescine
D011719
Pyrazines
D011739
Pyrimethamine
D011765
Pyruvaldehyde
C531164
RV09 compound
D011899
Ranitidine
D012293
Rifampin
C086492
Ro 24-5531
D012431
Rutin
C118852
S,S'-1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea
C530804
S,S'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea
D026422
S-Nitrosoglutathione
C065299
S-allylcysteine
C115461
SC 560
C120147
SIB 1757
C120148
SIB 1893
C118258
SN50 peptide
C110630
SR 144528
C458525
STO 609
D012643
Selenium
D012645
Selenomethionine
C116890
Semaxinib
D012839
Simazine
D020123
Sirolimus
D012906
Smoke
D012980
Sodium Salicylate
D017673
Sodium Chloride, Dietary
D013096
Spermine
D019311
Staurosporine
D013241
Sterigmatocystin
D013392
Sucralfate
D013458
Sulfur Dioxide
D013481
Superoxides
D013605
T-2 Toxin
D013654
Taurine
D013656
Taurocholic Acid
D013759
Tetrahydrocannabinol
D013792
Thalidomide
D013806
Theophylline
D008063
Thioctic Acid
D013864
Thioglycolates
D013874
Thiopental
D013890
Thiourea
D008625
Tiopronin
D014028
Tobacco Smoke Pollution
D014051
Toluene 2,4-Diisocyanate
D014107
Tosyllysine Chloromethyl Ketone
D014108
Tosylphenylalanyl Chloromethyl Ketone
D014118
Toxins, Biological
D014196
Trazodone
D014280
Triglycerides
D014307
Trioxsalen
D017329
Triptorelin Pamoate
D014315
Triterpenes
D014331
Tropicamide
D014414
Tungsten
D014501
Uranium
D014520
Urethane
D014639
Vanadium
D017968
Vanadium Compounds
C522219
Vaticanol B
D014801
Vitamin A
D024483
Vitamin K 3
D044004
Xanthones
D015016
Yohimbine
C088450
ZM 230487
C056165
acetovanillone
C074400
aciculatin
C106812
adefovir dipivoxil
C000188
alachlor
C006463
allyl alcohol
C102347
allylbenzene
C523074
allylpyrocatechol
C518327
aloe emodin
D024502
alpha-Tocopherol
C095512
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide
C064176
alpha-viniferin
C010845
aluminum chloride
C011164
amentoflavone
C078814
anandamide
C028304
anemonin
C023650
aniline
C117813
apicularen A
C071942
arctigenin
C000228
aristolochic acid I
C061640
arjunolic acid
C006632
arsenic trioxide
C058317
arsenic disulfide
C015001
arsenite
C005948
astaxanthine
C001579
astragalin
C065179
atorvastatin
C006680
baicalein
C044946
benazepril
C031403
benzyl isothiocyanate
C063964
bepafant
D019207
beta Carotene
D000338
beta-Aminoethyl Isothiourea
D019324
beta-Naphthoflavone
C008157
beta-ionone
C095105
bexarotene
C477843
bicyclol
C518535
bis(2-hydroxybenzylidene)acetone
C541028
bis(3-hydroxyphenyl) diselenide
C002791
bismuth tripotassium dicitrate
C102120
bisperoxo(1,10-phenanthroline)oxovanadate(1-)
C006780
bisphenol A
C016274
bromoacetate
C106525
broussochalcone A
C033373
butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine
C098384
cacospongionolide B
C055494
caffeic acid phenethyl ester
C058076
calpain inhibitor III
C071423
capsazepine
C571005
capseal I
C571006
capseal II
C043211
carvedilol
C078040
catalpol
C034221
catechol
C105934
celecoxib
C017133
chromous chloride
C039671
ciglitazone
C045645
cilostazol
C024989
coenzyme Q10
C098468
copper histidine
C030123
coumarin
C007164
cumene hydroperoxide
C029892
cupric chloride
C057862
cyanoginosin LR
C072247
cyclo(Trp-Asp-Pro-Val-Leu)
C017160
cypermethrin
C004742
daidzein
C512279
dendrochrysanene
C007262
deoxynivalenol
C493686
diacetylcurcumin
C532887
diarctigenin
C503840
dieckol
C449540
diferuloylputrescine
C015144
dihydrolipoic acid
C521105
dimethoxycurcumin
C039602
diosmetin
C007517
diphenyleneiodonium
C495419
diphenylmethyl selenocyanate
C035144
drospirenone
C067410
endothelium-dependent hyperpolarization factor
C044101
endotoxin, Escherichia coli
C118739
entinostat
C553039
epimuqubilin A
C007628
esculetin
C100807
ethyl N-allyl-N-(2-methyl-3-(4-(4-amidinophenoxycarbonyl)phenyl)propenoyl)aminoacetate methanesulfonate
C403134
ethyl-3-(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate
C007687
etiron
C496985
eugenosedin-A
C045325
eupatilin
C505499
eutigoside C
C024555
ferric chloride
C004999
ferulic acid
C093230
fexofenadine
C077139
fidarestat
C017875
fisetin
C043562
flavone
C029063
fructose-1,6-diphosphate
C025164
fucoxanthin
C056933
fumonisin B1
C040029
gabapentin
C064925
gadodiamide
C038958
gadolinium chloride
C001277
geldanamycin
C002963
geranylgeranyl pyrophosphate
C478099
gigantol
C007845
gingerol
C045856
ginkgolide B
C035054
ginsenoside Rg1
C097367
ginsenoside Rg3
C112772
ginsenoside M1
C046905
glucosamine 6-O-sulfate
C475739
glutamyl-(2-(((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)carbonyl)-3-((2-(1H-indol-3-yl)ethyl)amino)-3-oxopropyl)-cysteinyl-glycine sodium salt
C560287
glyceryl-isoeugenol
C086566
glycitein
C531349
glycyrol
C018562
guggulu extract
C020754
herbimycin
C013015
hesperetin
C031927
hydroquinone
C513449
icarisid II
C044834
iodixanol
C038192
iopromide
C041836
irsogladine
C036643
isoeugenol
C040920
isoliquiritigenin
C016527
isoquercitrin
C057531
jasplakinolide
C020251
kappa-casein glycomacropeptide
C570295
labdanolic acid methyl ester
C067713
lactacystin
C076948
lafutidine
C047781
lamotrigine
C037068
latrunculin B
C029891
lead chloride
C045463
leflunomide
C002385
linsidomine
C009900
lipoteichoic acid
C040527
lipoxin A4
C059516
loganin
C059451
lornoxicam
C040656
loxoprofen
C015330
lycorine
C458419
malvidin-3-glucoside
C054474
manumycin
C054938
methoctramine
C445068
methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate
C455529
methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate
C517880
monascin
C035359
monorden
C507582
monotropein
C093875
montelukast
C008548
morin
C046170
naphthenic acid
C005273
naringenin
C490266
neoechinulin A
C029938
nickel sulfate
C014707
nitrosobenzylmethylamine
C038405
nivalenol
C016340
o,p'-DDT
C002769
oleuropein
C053238
onapristone
C485800
osajin
C036006
oxcarbazepine
C119540
oxodiperoxo(pyridine-2-carboxylate)vanadate(V)
C117045
p-hydroxycinnamaldehyde
C013638
paeonol
C010272
palytoxin
C084656
paricalcitol
C066957
pelargonidin
C118309
petrosaspongiolide m
C040601
phenanthridone
C058305
phenethyl isothiocyanate
C064093
phlorofucofuroeckol A
C108475
pitavastatin
C036455
praeruptorin E
C058808
praeruptorin C
C441070
praeruptorin A
C009042
pristane
C066229
prolinedithiocarbamate
C009091
protocatechuic acid
C095781
protolichesterinic acid
C028025
protoporphyrin IX
C435940
quercetin pentaacetate
C523166
quercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside
C073340
ranitidine bismuth citrate
C052785
rebamipide
C024353
resiniferatoxin
C402365
resiquimod
C089032
rimonabant
C116926
rofecoxib
C529148
rosavin
C547390
rossicaside B
C422923
rosuvastatin
C099154
ruboxistaurin
C066201
salvianolic acid A
C076944
salvianolic acid B
C018381
salvin
C436447
sangre de grado
C410958
sauchinone
C484876
scutellarin
C002979
selenomethylselenocysteine
C097256
semapimod
C016727
sepiapterin
C047352
septilin
C112356
seryl-leucyl-isoleucyl-glycyl--arginyl-leucinamide
C054125
sesamin
C040115
shogaol
C073734
sinapinic acid
C009277
sodium arsenate
C035933
sophocarpine
C056684
soyasaponin I
C106126
soyasaponin II
C009354
sulglicotide
C029222
sym-trinitrobenzene
C061133
tamibarotene
C112765
tanespimycin
C001803
tempol
C480848
tephrosin
D020002
tert-Butyl Alcohol
D020122
tert-Butylhydroperoxide
C038096
tert-butylcatechol
C501362
terutroban
C004648
testosterone enanthate
C045037
testosterone-3-carboxymethyloxime-bovine serum albumin conjugate
C009438
tetrandrine
C030950
thiaton
C055421
tin mesoporphyrin
C009495
titanium dioxide
C052342
topiramate
C031815
toxB protein, Clostridium difficile
C447082
tricarbonyldichlororuthenium (II) dimer
C046498
tricyclodecane-9-yl-xanthogenate
C073339
usnic acid
C570018
vicanicin
C025643
vinclozolin
C412469
vitisin A
C111237
vorinostat
C009687
wortmannin
C528421
wuzi yanzong
C011145
zaprinast
C016837
zinc chloride
C017803
zinc protoporphyrin
C088658
zoledronic acid
C022189
zonisamide
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR003097 - FAD-binding_1
IPR017927 - Fd_Rdtase_FAD-bd
IPR001094 - Flavdoxin
IPR008254 - Flavodoxin/NO_synth
IPR001709 - Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR023173 - NADPH_Cyt_P450_Rdtase_dom3
IPR004030 - NO_synthase_oxygenase_dom
IPR026009 - NOS
IPR012144 - NOS_met
IPR001433 - OxRdtase_FAD/NAD-bd
IPR017938 - Riboflavin_synthase-like_b-brl
Pfam Domains: PF00175 - Oxidoreductase NAD-binding domain
PF00258 - Flavodoxin
PF00667 - FAD binding domain
PF02898 - Nitric oxide synthase, oxygenase domain
SCOP Domains: 63380 - Riboflavin synthase domain-like
52218 - Flavoproteins
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
56512 - Nitric oxide (NO) synthase oxygenase domain
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on P35228
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK310926 - Homo sapiens cDNA, FLJ17968.U20141 - Human inducible nitric oxide synthase mRNA, complete cds.D26525 - Homo sapiens mRNA for inducible type of nitric oxide synthase, complete cds.U31511 - Human inducible nitric oxide synthase (NOS) mRNA, complete cds.HV708936 - JP 2012506450-A/34: Methods for treating eye disorders.L09210 - Homo sapiens inducible nitric oxide synthase mRNA, complete cds.X73029 - H.sapiens mRNA for nitric oxide synthase.AF068236 - Homo sapiens inducible nitric oxide synthase (NOS) mRNA, complete cds.JD364715 - Sequence 345739 from Patent EP1572962.JD451597 - Sequence 432621 from Patent EP1572962.JD534464 - Sequence 515488 from Patent EP1572962.JD364720 - Sequence 345744 from Patent EP1572962.JD398127 - Sequence 379151 from Patent EP1572962.BC130283 - Homo sapiens nitric oxide synthase 2, inducible, mRNA (cDNA clone MGC:163155 IMAGE:40146314), complete cds.BC144126 - Homo sapiens nitric oxide synthase 2, inducible, mRNA (cDNA clone MGC:177663 IMAGE:9052646), complete cds.U05810 - Human inducible nitric oxide synthase mRNA, complete cds.JD362659 - Sequence 343683 from Patent EP1572962.JD269110 - Sequence 250134 from Patent EP1572962.JD435741 - Sequence 416765 from Patent EP1572962.L24553 - Homo sapiens inducible nitric oxide synthase mRNA, complete cds.JD105506 - Sequence 86530 from Patent EP1572962.AB022318 - Homo sapiens mRNA for inducible nitric oxide synthase, complete cds.HQ258688 - Synthetic construct Homo sapiens clone IMAGE:100072718 nitric oxide synthase 2, inducible (NOS2) gene, encodes complete protein.JD221797 - Sequence 202821 from Patent EP1572962.AK304252 - Homo sapiens cDNA FLJ60219 complete cds, highly similar to Nitric oxide synthase, inducible (EC 1.14.13.39).JD314018 - Sequence 295042 from Patent EP1572962.S75615 - iNOS=nitric oxide synthase [human, renal proximal tubular cells, mRNA Partial, 283 nt].S76479 - calcium-calmodulin independent nitric oxide synthase iNOS [human, Epstein-Barr virus-transformed Burkitt's lymphoma cell line, Akata, mRNA, 180 nt].JD390129 - Sequence 371153 from Patent EP1572962.JD227443 - Sequence 208467 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: A1L3U5, B7ZLY2, ENST00000313735.1, ENST00000313735.10, ENST00000313735.2, ENST00000313735.3, ENST00000313735.4, ENST00000313735.5, ENST00000313735.6, ENST00000313735.7, ENST00000313735.8, ENST00000313735.9, NM_000625, NOS2 , NOS2A, NOS2_HUMAN, O60757, O94994, P35228, Q16263, Q16692, Q4TTS5, Q9UD42, uc317pme.1, uc317pme.2UCSC ID: ENST00000313735.11_10RefSeq Accession: NM_000625.4
Protein: P35228
(aka NOS2_HUMAN)
Gene Model Information
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for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.