ID:NOX3_HUMAN DESCRIPTION: RecName: Full=NADPH oxidase 3; EC=1.6.3.-; AltName: Full=Mitogenic oxidase 2; Short=MOX-2; AltName: Full=gp91phox homolog 3; Short=GP91-3; FUNCTION: NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. ENZYME REGULATION: Activated by the ototoxic drug cisplatin (By similarity). Activated by NOXO1. Cooperatively activated by NCF1 and NCF2 or NOXA1 in a phorbol 12-myristate 13-acetate (PMA)- dependent manner. Inhibited by diphenyleneiodonium chloride. SUBUNIT: Interacts with and stabilizes CYBA/p22phox. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). DEVELOPMENTAL STAGE: Expressed in fetal kidney and to a lower extent in liver, lung and spleen. SIMILARITY: Contains 1 FAD-binding FR-type domain. SIMILARITY: Contains 1 ferric oxidoreductase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01794 - Ferric reductase like transmembrane component PF08022 - FAD-binding domain PF08030 - Ferric reductase NAD binding domain
SCOP Domains: 63380 - Riboflavin synthase domain-like 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain 82856 - L-A virus major coat protein
ModBase Predicted Comparative 3D Structure on Q9HBY0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
