ID:NPL4_HUMAN DESCRIPTION: RecName: Full=Nuclear protein localization protein 4 homolog; Short=Protein NPL4; FUNCTION: The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). PATHWAY: Protein degradation; proteasomal ubiquitin-dependent pathway. SUBUNIT: Heterodimer with UFD1L. The heterodimer binds ubiquitinated proteins. The heterodimer binds to VCP and inhibits Golgi membrane fusion. SUBCELLULAR LOCATION: Cytoplasm, cytosol (By similarity). Endoplasmic reticulum (By similarity). Nucleus (By similarity). Note=Associated with the endoplasmic reticulum and nuclear (By similarity). TISSUE SPECIFICITY: Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver. DOMAIN: Binds ubiquitinated proteins via its RanBP2-type zinc finger. SIMILARITY: Belongs to the NPL4 family. SIMILARITY: Contains 1 RanBP2-type zinc finger. SEQUENCE CAUTION: Sequence=BAA91314.1; Type=Erroneous initiation; Sequence=BAA96023.1; Type=Erroneous initiation; Sequence=BAB14372.1; Type=Erroneous initiation; Sequence=BAB14499.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00641 - Zn-finger in Ran binding protein and others PF05020 - NPL4 family, putative zinc binding region PF05021 - NPL4 family PF11543 - Nuclear pore localisation protein NPL4
SCOP Domains: 54236 - Ubiquitin-like 90209 - Ran binding protein zinc finger-like
ModBase Predicted Comparative 3D Structure on Q8TAT6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006511 ubiquitin-dependent protein catabolic process GO:0007030 Golgi organization GO:0030433 ER-associated ubiquitin-dependent protein catabolic process GO:0030970 retrograde protein transport, ER to cytosol GO:0032480 negative regulation of type I interferon production GO:0039536 negative regulation of RIG-I signaling pathway GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0070987 error-free translesion synthesis
AK000664 - Homo sapiens cDNA FLJ20657 fis, clone KAT01069. AK023272 - Homo sapiens cDNA FLJ13210 fis, clone NT2RP4000528, weakly similar to NPL4 PROTEIN. AK023046 - Homo sapiens cDNA FLJ12984 fis, clone NT2RP3000047, weakly similar to NPL4 PROTEIN. BC025930 - Homo sapiens nuclear protein localization 4 homolog (S. cerevisiae), mRNA (cDNA clone MGC:31840 IMAGE:5017718), complete cds. AL834300 - Homo sapiens mRNA; cDNA DKFZp762C213 (from clone DKFZp762C213). DQ895356 - Synthetic construct Homo sapiens clone IMAGE:100009816; FLH183590.01L; RZPDo839E05141D nuclear protein localization 4 homolog (S. cerevisiae) (NPLOC4) gene, encodes complete protein. AB040932 - Homo sapiens mRNA for KIAA1499 protein, partial cds. AK294473 - Homo sapiens cDNA FLJ57969 complete cds, highly similar to Nuclear protein localization protein 4 homolog. AB462921 - Synthetic construct DNA, clone: pF1KSDA1499, Homo sapiens NPLOC4 gene for nuclear protein localization 4 homolog, without stop codon, in Flexi system. AL133629 - Homo sapiens mRNA; cDNA DKFZp434N1223 (from clone DKFZp434N1223). AK074322 - Homo sapiens cDNA FLJ23742 fis, clone HEP15403. BC013406 - Homo sapiens nuclear protein localization 4 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:2967712). AK024398 - Homo sapiens cDNA FLJ14336 fis, clone PLACE4000487. JD111029 - Sequence 92053 from Patent EP1572962. JD384580 - Sequence 365604 from Patent EP1572962. JD181370 - Sequence 162394 from Patent EP1572962. JD026733 - Sequence 7757 from Patent EP1572962. JD032424 - Sequence 13448 from Patent EP1572962. DQ595391 - Homo sapiens piRNA piR-61503, complete sequence. JD409904 - Sequence 390928 from Patent EP1572962. JD364689 - Sequence 345713 from Patent EP1572962. JD115509 - Sequence 96533 from Patent EP1572962. JD162232 - Sequence 143256 from Patent EP1572962. JD275797 - Sequence 256821 from Patent EP1572962. JD130871 - Sequence 111895 from Patent EP1572962. JD532429 - Sequence 513453 from Patent EP1572962. JD547442 - Sequence 528466 from Patent EP1572962. JD387890 - Sequence 368914 from Patent EP1572962. JD419948 - Sequence 400972 from Patent EP1572962. DQ587568 - Homo sapiens piRNA piR-54680, complete sequence. JD189236 - Sequence 170260 from Patent EP1572962. JD143160 - Sequence 124184 from Patent EP1572962. JD257503 - Sequence 238527 from Patent EP1572962. JD289368 - Sequence 270392 from Patent EP1572962. JD201037 - Sequence 182061 from Patent EP1572962. JD273512 - Sequence 254536 from Patent EP1572962. JD449500 - Sequence 430524 from Patent EP1572962. LF209447 - JP 2014500723-A/16950: Polycomb-Associated Non-Coding RNAs. JD445160 - Sequence 426184 from Patent EP1572962. JD533390 - Sequence 514414 from Patent EP1572962. JD300196 - Sequence 281220 from Patent EP1572962. JD229069 - Sequence 210093 from Patent EP1572962. JD403660 - Sequence 384684 from Patent EP1572962. JD442099 - Sequence 423123 from Patent EP1572962. LF328577 - JP 2014500723-A/136080: Polycomb-Associated Non-Coding RNAs. JD515628 - Sequence 496652 from Patent EP1572962. AK311741 - Homo sapiens cDNA, FLJ18783. LF328578 - JP 2014500723-A/136081: Polycomb-Associated Non-Coding RNAs. JD115726 - Sequence 96750 from Patent EP1572962. JD189289 - Sequence 170313 from Patent EP1572962. JD098599 - Sequence 79623 from Patent EP1572962. JD452087 - Sequence 433111 from Patent EP1572962. LF328579 - JP 2014500723-A/136082: Polycomb-Associated Non-Coding RNAs. JD480650 - Sequence 461674 from Patent EP1572962. JD483234 - Sequence 464258 from Patent EP1572962. JD110561 - Sequence 91585 from Patent EP1572962. JD387557 - Sequence 368581 from Patent EP1572962. MA564154 - JP 2018138019-A/136080: Polycomb-Associated Non-Coding RNAs. MA564155 - JP 2018138019-A/136081: Polycomb-Associated Non-Coding RNAs. MA564156 - JP 2018138019-A/136082: Polycomb-Associated Non-Coding RNAs. MA445024 - JP 2018138019-A/16950: Polycomb-Associated Non-Coding RNAs. DQ587272 - Homo sapiens piRNA piR-54384, complete sequence. DQ575019 - Homo sapiens piRNA piR-43131, complete sequence. JD210693 - Sequence 191717 from Patent EP1572962. JD484913 - Sequence 465937 from Patent EP1572962. JD484762 - Sequence 465786 from Patent EP1572962. JD462697 - Sequence 443721 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8TAT6 (Reactome details) participates in the following event(s):
R-HSA-5654985 SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH R-HSA-5654989 SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA R-HSA-110320 Translesion Synthesis by POLH R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-73893 DNA Damage Bypass R-HSA-73894 DNA Repair
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
