Human Gene NPY (ENST00000242152.7_4) from GENCODE V47lift37
  Description: neuropeptide Y (from RefSeq NM_000905.4)
Gencode Transcript: ENST00000242152.7_4
Gencode Gene: ENSG00000122585.8_7
Transcript (Including UTRs)
   Position: hg19 chr7:24,323,809-24,331,481 Size: 7,673 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr7:24,324,860-24,331,306 Size: 6,447 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:24,323,809-24,331,481)mRNA (may differ from genome)Protein (97 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMalacardsMGIOMIMPubMed
ReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NPY_HUMAN
DESCRIPTION: RecName: Full=Pro-neuropeptide Y; Contains: RecName: Full=Neuropeptide Y; AltName: Full=Neuropeptide tyrosine; Short=NPY; Contains: RecName: Full=C-flanking peptide of NPY; Short=CPON; Flags: Precursor;
FUNCTION: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.
SIMILARITY: Belongs to the NPY family.
WEB RESOURCE: Name=Wikipedia; Note=Neuropeptide Y entry; URL="http://en.wikipedia.org/wiki/Neuropeptide_Y";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NPY
Diseases sorted by gene-association score: autonomic neuropathy (19), eating disorder (15), temporal lobe epilepsy (14), anorexia nervosa (13), reflex sympathetic dystrophy (13), normal pressure hydrocephalus (13), adjustment disorder (12), status epilepticus (12), bulimia nervosa (11), complex regional pain syndrome (9), epispadias (9), anxiety disorder (8), phaeochromocytoma (8), mood disorder (7), tendinosis (7), carcinoid syndrome (7), substance abuse (6), stereotypic movement disorder (5), obesity (5), toxic myocarditis (5), von hippel-lindau syndrome (5), degenerative disc disease (5), overnutrition (4), alcohol dependence (4), indeterminate leprosy (4), intermittent explosive disorder (4), congestive heart failure (3), ewing sarcoma (3), pheochromocytoma (3), diabetes mellitus, insulin-dependent (2), hypertension, essential (1), attention deficit-hyperactivity disorder (1), hirschsprung disease 1 (1), acquired metabolic disease (1), myocardial infarction (1), schizophrenia (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 71.00 RPKM in Brain - Caudate (basal ganglia)
Total median expression: 356.32 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -18.4086-0.214 Picture PostScript Text
3' UTR -29.50175-0.169 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001955 - Pancreatic_hormone-like
IPR020392 - Pancreatic_hormone-like_CS

Pfam Domains:
PF00159 - Pancreatic hormone peptide

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1QFA - NMR 1RON - NMR


ModBase Predicted Comparative 3D Structure on P01303
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001664 G-protein coupled receptor binding
GO:0004930 G-protein coupled receptor activity
GO:0005102 receptor binding
GO:0005179 hormone activity
GO:0005184 neuropeptide hormone activity
GO:0005246 calcium channel regulator activity

Biological Process:
GO:0001878 response to yeast
GO:0006816 calcium ion transport
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007218 neuropeptide signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007631 feeding behavior
GO:0008217 regulation of blood pressure
GO:0008283 cell proliferation
GO:0008343 adult feeding behavior
GO:0010469 regulation of receptor activity
GO:0019731 antibacterial humoral response
GO:0019732 antifungal humoral response
GO:0021954 central nervous system neuron development
GO:0021987 cerebral cortex development
GO:0031175 neuron projection development
GO:0032098 regulation of appetite
GO:0032100 positive regulation of appetite
GO:0045087 innate immune response
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005623 cell
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus


-  Descriptions from all associated GenBank mRNAs
  KJ897256 - Synthetic construct Homo sapiens clone ccsbBroadEn_06650 NPY gene, encodes complete protein.
LF213032 - JP 2014500723-A/20535: Polycomb-Associated Non-Coding RNAs.
LF212028 - JP 2014500723-A/19531: Polycomb-Associated Non-Coding RNAs.
LF207135 - JP 2014500723-A/14638: Polycomb-Associated Non-Coding RNAs.
BC029497 - Homo sapiens neuropeptide Y, mRNA (cDNA clone MGC:33138 IMAGE:5278692), complete cds.
AK312156 - Homo sapiens cDNA, FLJ92442, Homo sapiens neuropeptide Y (NPY), mRNA.
K01911 - Human neuropeptide Y (NPY) mRNA, complete cds.
JD204766 - Sequence 185790 from Patent EP1572962.
M15789 - Human neuropeptide Y mRNA, complete cds.
AB590306 - Synthetic construct DNA, clone: pFN21AE1480, Homo sapiens NPY gene for neuropeptide Y, without stop codon, in Flexi system.
DQ893335 - Synthetic construct clone IMAGE:100005965; FLH196321.01X; RZPDo839A11156D neuropeptide Y (NPY) gene, encodes complete protein.
DQ896651 - Synthetic construct Homo sapiens clone IMAGE:100011111; FLH196317.01L; RZPDo839A11155D neuropeptide Y (NPY) gene, encodes complete protein.
JD232003 - Sequence 213027 from Patent EP1572962.
JD233209 - Sequence 214233 from Patent EP1572962.
JD276710 - Sequence 257734 from Patent EP1572962.
JD056708 - Sequence 37732 from Patent EP1572962.
JD411437 - Sequence 392461 from Patent EP1572962.
JD334555 - Sequence 315579 from Patent EP1572962.
MA448609 - JP 2018138019-A/20535: Polycomb-Associated Non-Coding RNAs.
MA447605 - JP 2018138019-A/19531: Polycomb-Associated Non-Coding RNAs.
MA442712 - JP 2018138019-A/14638: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P01303 (Reactome details) participates in the following event(s):

R-HSA-388863 Neuropeptide Y receptors can bind neuropeptide Y-related peptides
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000242152.1, ENST00000242152.2, ENST00000242152.3, ENST00000242152.4, ENST00000242152.5, ENST00000242152.6, NM_000905, NPY_HUMAN, P01303, uc317ejp.1, uc317ejp.2
UCSC ID: ENST00000242152.7_4
RefSeq Accession: NM_000905.4
Protein: P01303 (aka NPY_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.