ID:NQO1_HUMAN DESCRIPTION: RecName: Full=NAD(P)H dehydrogenase [quinone] 1; EC=1.6.5.2; AltName: Full=Azoreductase; AltName: Full=DT-diaphorase; Short=DTD; AltName: Full=Menadione reductase; AltName: Full=NAD(P)H:quinone oxidoreductase 1; AltName: Full=Phylloquinone reductase; AltName: Full=Quinone reductase 1; Short=QR1; FUNCTION: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. CATALYTIC ACTIVITY: NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone. COFACTOR: FAD. ENZYME REGULATION: Inhibited by dicoumarol. SUBUNIT: Homodimer. INTERACTION: O88898-2:Tp63 (xeno); NbExp=2; IntAct=EBI-3989435, EBI-2338228; O88898-6:Tp63 (xeno); NbExp=2; IntAct=EBI-3989435, EBI-2338244; SUBCELLULAR LOCATION: Cytoplasm. INDUCTION: By dioxin. MASS SPECTROMETRY: Mass=30864; Mass_error=6; Method=Electrospray; Range=1-274; Source=PubMed:11735396; POLYMORPHISM: The Ser-187 polymorphism may be linked to susceptibility to forms of cancers. MISCELLANEOUS: Quinone reductase accepts electrons from both NADH and NADPH with equal efficiency. SIMILARITY: Belongs to the NAD(P)H dehydrogenase (quinone) family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/NQO1ID375.html"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/nqo1/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P15559
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006521 regulation of cellular amino acid metabolic process GO:0006801 superoxide metabolic process GO:0006805 xenobiotic metabolic process GO:0006809 nitric oxide biosynthetic process GO:0006979 response to oxidative stress GO:0007271 synaptic transmission, cholinergic GO:0007568 aging GO:0007584 response to nutrient GO:0009636 response to toxic substance GO:0014070 response to organic cyclic compound GO:0019430 removal of superoxide radicals GO:0032355 response to estradiol GO:0043066 negative regulation of apoptotic process GO:0043086 negative regulation of catalytic activity GO:0043525 positive regulation of neuron apoptotic process GO:0045471 response to ethanol GO:0051602 response to electrical stimulus GO:0055114 oxidation-reduction process GO:0070301 cellular response to hydrogen peroxide GO:0071248 cellular response to metal ion GO:1901698 response to nitrogen compound GO:1904880 response to hydrogen sulfide
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
