ID:NR4A2_HUMAN DESCRIPTION: RecName: Full=Nuclear receptor subfamily 4 group A member 2; AltName: Full=Immediate-early response protein NOT; AltName: Full=Orphan nuclear receptor NURR1; AltName: Full=Transcriptionally-inducible nuclear receptor; FUNCTION: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). SUBUNIT: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3 (By similarity). INTERACTION: Q5H9L2:TCEAL5; NbExp=2; IntAct=EBI-2681738, EBI-2681773; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue. DEVELOPMENTAL STAGE: Rapidly and only very transiently expressed after cell activation, during the G0-G1 transition of the cell cycle. SIMILARITY: Belongs to the nuclear hormone receptor family. NR4 subfamily. SIMILARITY: Contains 1 nuclear receptor DNA-binding domain. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/NR4A2";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P43354
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003707 steroid hormone receptor activity GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0005515 protein binding GO:0008013 beta-catenin binding GO:0008270 zinc ion binding GO:0035259 glucocorticoid receptor binding GO:0042803 protein homodimerization activity GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding GO:0046965 retinoid X receptor binding GO:0046982 protein heterodimerization activity
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001666 response to hypoxia GO:0001764 neuron migration GO:0001975 response to amphetamine GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006367 transcription initiation from RNA polymerase II promoter GO:0007165 signal transduction GO:0007399 nervous system development GO:0008344 adult locomotory behavior GO:0009791 post-embryonic development GO:0010467 gene expression GO:0010468 regulation of gene expression GO:0021952 central nervous system projection neuron axonogenesis GO:0021953 central nervous system neuron differentiation GO:0021986 habenula development GO:0030182 neuron differentiation GO:0030522 intracellular receptor signaling pathway GO:0031668 cellular response to extracellular stimulus GO:0034599 cellular response to oxidative stress GO:0042053 regulation of dopamine metabolic process GO:0042416 dopamine biosynthetic process GO:0042417 dopamine metabolic process GO:0042551 neuron maturation GO:0043085 positive regulation of catalytic activity GO:0043401 steroid hormone mediated signaling pathway GO:0043524 negative regulation of neuron apoptotic process GO:0043576 regulation of respiratory gaseous exchange GO:0045444 fat cell differentiation GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0051866 general adaptation syndrome GO:0060070 canonical Wnt signaling pathway GO:0071376 cellular response to corticotropin-releasing hormone stimulus GO:0071542 dopaminergic neuron differentiation GO:1904948 midbrain dopaminergic neuron differentiation GO:2001234 negative regulation of apoptotic signaling pathway
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
