Human Gene NRARP (ENST00000356628.4_6) from GENCODE V47lift37
  Description: NOTCH regulated ankyrin repeat protein (from RefSeq NM_001004354.3)
Gencode Transcript: ENST00000356628.4_6
Gencode Gene: ENSG00000198435.4_9
Transcript (Including UTRs)
   Position: hg19 chr9:140,194,083-140,196,723 Size: 2,641 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr9:140,196,036-140,196,380 Size: 345 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:140,194,083-140,196,723)mRNA (may differ from genome)Protein (114 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NRARP_HUMAN
DESCRIPTION: RecName: Full=Notch-regulated ankyrin repeat-containing protein;
FUNCTION: May play a role in the formation of somites (By similarity).
SIMILARITY: Belongs to the NRARP family.
SIMILARITY: Contains 2 ANK repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 34.15 RPKM in Colon - Transverse
Total median expression: 282.43 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -223.90343-0.653 Picture PostScript Text
3' UTR -724.901953-0.371 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom

Pfam Domains:
PF00023 - Ankyrin repeat
PF12796 - Ankyrin repeats (3 copies)
PF13606 - Ankyrin repeat
PF13637 - Ankyrin repeats (many copies)
PF13857 - Ankyrin repeats (many copies)

SCOP Domains:
140860 - Pseudo ankyrin repeat-like
48403 - Ankyrin repeat

ModBase Predicted Comparative 3D Structure on Q7Z6K4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002040 sprouting angiogenesis
GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organism development
GO:0022407 regulation of cell-cell adhesion
GO:0032525 somite rostral/caudal axis specification
GO:0045581 negative regulation of T cell differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1902367 negative regulation of Notch signaling pathway involved in somitogenesis


-  Descriptions from all associated GenBank mRNAs
  AJ420434 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1499812.
BC053618 - Homo sapiens NOTCH-regulated ankyrin repeat protein, mRNA (cDNA clone MGC:61598 IMAGE:6143133), complete cds.
HQ448596 - Synthetic construct Homo sapiens clone IMAGE:100072034; CCSB011940_01 Notch-regulated ankyrin repeat protein (NRARP) gene, encodes complete protein.
KJ896285 - Synthetic construct Homo sapiens clone ccsbBroadEn_05679 NRARP gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: B8A4K5, ENST00000356628.1, ENST00000356628.2, ENST00000356628.3, NM_001004354, NRARP_HUMAN, Q7Z6K4, uc317zqj.1, uc317zqj.2
UCSC ID: ENST00000356628.4_6
RefSeq Accession: NM_001004354.3
Protein: Q7Z6K4 (aka NRARP_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.