ID:NRG2_HUMAN DESCRIPTION: RecName: Full=Pro-neuregulin-2, membrane-bound isoform; Short=Pro-NRG2; Contains: RecName: Full=Neuregulin-2; Short=NRG-2; AltName: Full=Divergent of neuregulin-1; Short=DON-1; AltName: Full=Neural- and thymus-derived activator for ERBB kinases; Short=NTAK; Flags: Precursor; FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor. SUBUNIT: Interacts with ERBB3 and ERBB4. SUBCELLULAR LOCATION: Pro-neuregulin-2, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein (By similarity). Note=Does not seem to be active (By similarity). SUBCELLULAR LOCATION: Neuregulin-2: Secreted (By similarity). TISSUE SPECIFICITY: Restricted to the cerebellum in the adult. DOMAIN: The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity). DOMAIN: ERBB receptor binding is elicited entirely by the EGF-like domain (By similarity). PTM: Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form (By similarity). PTM: Extensive glycosylation precedes the proteolytic cleavage (By similarity). SIMILARITY: Belongs to the neuregulin family. SIMILARITY: Contains 1 EGF-like domain. SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14511
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000165 MAPK cascade GO:0007165 signal transduction GO:0010469 regulation of receptor activity GO:0018108 peptidyl-tyrosine phosphorylation GO:0035556 intracellular signal transduction GO:0038128 ERBB2 signaling pathway GO:0046854 phosphatidylinositol phosphorylation GO:0048513 animal organ development GO:0051897 positive regulation of protein kinase B signaling GO:2000145 regulation of cell motility
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
