ID:NRG3_HUMAN DESCRIPTION: RecName: Full=Pro-neuregulin-3, membrane-bound isoform; Short=Pro-NRG3; Contains: RecName: Full=Neuregulin-3; Short=NRG-3; Flags: Precursor; FUNCTION: Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. SUBUNIT: Interacts with ERBB4. SUBCELLULAR LOCATION: Pro-neuregulin-3, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein (By similarity). Note=Does not seem to be active (By similarity). SUBCELLULAR LOCATION: Neuregulin-3: Secreted (By similarity). SUBCELLULAR LOCATION: Isoform 3: Cell membrane; Single-pass type I membrane protein. Note=Isoform 3 is also proteolytically released as a soluble form. TISSUE SPECIFICITY: Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. DEVELOPMENTAL STAGE: Isoform 3 is expressed in fetal brain but not in other fetal tissues. DOMAIN: The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity). DOMAIN: ERBB receptor binding is elicited entirely by the EGF-like domain (By similarity). PTM: Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. PTM: Extensive glycosylation precedes the proteolytic cleavage (By similarity). Isoform 3 is glycosylated. SIMILARITY: Belongs to the neuregulin family. SIMILARITY: Contains 1 EGF-like domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P56975
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001558 regulation of cell growth GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity GO:0007389 pattern specification process GO:0010469 regulation of receptor activity GO:0021842 chemorepulsion involved in interneuron migration from the subpallium to the cortex GO:0030879 mammary gland development GO:0035556 intracellular signal transduction GO:0048513 animal organ development GO:0060596 mammary placode formation GO:2001223 negative regulation of neuron migration
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
