Human Gene NRIP1 (ENST00000318948.7_7) from GENCODE V47lift37
  Description: nuclear receptor interacting protein 1 (from RefSeq NM_003489.4)
Gencode Transcript: ENST00000318948.7_7
Gencode Gene: ENSG00000180530.11_12
Transcript (Including UTRs)
   Position: hg19 chr21:16,333,556-16,437,321 Size: 103,766 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr21:16,337,037-16,340,513 Size: 3,477 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr21:16,333,556-16,437,321)mRNA (may differ from genome)Protein (1158 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NRIP1_HUMAN
DESCRIPTION: RecName: Full=Nuclear receptor-interacting protein 1; AltName: Full=Nuclear factor RIP140; AltName: Full=Receptor-interacting protein 140;
FUNCTION: Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors.
SUBUNIT: Interacts with RARA and RXRB homodimers and RARA/RXRB heterodimers in the presence of ligand. Interacts with HDAC1 and HDAC3 via its N-terminal domain. Interacts with NR2C1 (sumoylated form and via the ligand-binding domain); the interaction results in promoting the repressor activity of NR2C1 (By similarity). Interacts with CTBP1, CTBP2, ESR1, HDAC1, HDAC2, HDAC5, HDAC6, NR2C2, NR3C1, NR3C2, YWHAH, JUN and FOS. Found in a complex with both NR3C1 and YWHAH. Interacts with ZNF366.
INTERACTION: Q8NHQ1:CEP70; NbExp=3; IntAct=EBI-746484, EBI-739624; Q13642:FHL1; NbExp=6; IntAct=EBI-746484, EBI-912547; O95751:LDOC1; NbExp=3; IntAct=EBI-746484, EBI-740738; Q8N895:ZNF366; NbExp=2; IntAct=EBI-746484, EBI-2813661;
SUBCELLULAR LOCATION: Nucleus. Note=Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand- bound NR3C1.
DOMAIN: Contains 9 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which have different affinities for nuclear receptors. The C-terminal LTKTNPILYYMLQK motif is required for ligand-dependent interaction with RAAR and RXRB homodimers and heterodimers, for the corepressor activity, and for the formation of an HDAC3 complex with RARA/RXRB (By similarity). Contains at least four autonomous repression domains (RD1-4). RD1 functions via a histone deacetylase (HDAC)-independent mechanism, whereas RD2, RD3 and RD4 can function by HDAC-dependent or independent mechanisms, depending on cell type. RD2 is dependent on CTBP binding.
PTM: Acetylation regulates its nuclear translocation and corepressive activity (By similarity). Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NRIP1
Diseases sorted by gene-association score: embryonal carcinoma (4), infertility (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.56 RPKM in Cervix - Endocervix
Total median expression: 243.18 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -262.40793-0.331 Picture PostScript Text
3' UTR -801.343481-0.230 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026649 - NRIP1

Pfam Domains:
PF15687 - Nuclear receptor-interacting protein 1 repression 1
PF15688 - Nuclear receptor-interacting protein 1 repression 2
PF15689 - Nuclear receptor-interacting protein 1 repression 3
PF15690 - Nuclear receptor-interacting protein 1 repression 4

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2GPO - X-ray MuPIT 2GPP - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P48552
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001046 core promoter sequence-specific DNA binding
GO:0003712 transcription cofactor activity
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0030331 estrogen receptor binding
GO:0035257 nuclear hormone receptor binding
GO:0035259 glucocorticoid receptor binding
GO:0042826 histone deacetylase binding
GO:0042974 retinoic acid receptor binding
GO:0046965 retinoid X receptor binding
GO:0050681 androgen receptor binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001543 ovarian follicle rupture
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007623 circadian rhythm
GO:0019915 lipid storage
GO:0030521 androgen receptor signaling pathway
GO:0030728 ovulation
GO:0032922 circadian regulation of gene expression
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048511 rhythmic process
GO:0071392 cellular response to estradiol stimulus

Cellular Component:
GO:0000118 histone deacetylase complex
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0016607 nuclear speck


-  Descriptions from all associated GenBank mRNAs
  AK289786 - Homo sapiens cDNA FLJ77253 complete cds, highly similar to Homo sapiens nuclear receptor interacting protein 1 (NRIP1), mRNA.
HF584749 - Homo sapiens mRNA for partial nuclear receptor interacting protein 1 (NRIP1_var1 gene).
HF584750 - Homo sapiens mRNA for partial nuclear receptor interacting protein 1 (NRIP1_var2 gene).
X84373 - H.sapiens mRNA for nuclear factor RIP140.
AK123818 - Homo sapiens cDNA FLJ41824 fis, clone NT2RI2018950.
JD377250 - Sequence 358274 from Patent EP1572962.
JD491154 - Sequence 472178 from Patent EP1572962.
JD172309 - Sequence 153333 from Patent EP1572962.
JD252855 - Sequence 233879 from Patent EP1572962.
JD086689 - Sequence 67713 from Patent EP1572962.
JD439875 - Sequence 420899 from Patent EP1572962.
JD281704 - Sequence 262728 from Patent EP1572962.
JD235008 - Sequence 216032 from Patent EP1572962.
JD244756 - Sequence 225780 from Patent EP1572962.
JD296435 - Sequence 277459 from Patent EP1572962.
JD502371 - Sequence 483395 from Patent EP1572962.
JD312978 - Sequence 294002 from Patent EP1572962.
JD302043 - Sequence 283067 from Patent EP1572962.
JD051483 - Sequence 32507 from Patent EP1572962.
JD110275 - Sequence 91299 from Patent EP1572962.
JD110292 - Sequence 91316 from Patent EP1572962.
JD520942 - Sequence 501966 from Patent EP1572962.
JD089120 - Sequence 70144 from Patent EP1572962.
JD189250 - Sequence 170274 from Patent EP1572962.
JD040638 - Sequence 21662 from Patent EP1572962.
JD520916 - Sequence 501940 from Patent EP1572962.
JD520915 - Sequence 501939 from Patent EP1572962.
JD202495 - Sequence 183519 from Patent EP1572962.
JD523987 - Sequence 505011 from Patent EP1572962.
JD526569 - Sequence 507593 from Patent EP1572962.
JD548445 - Sequence 529469 from Patent EP1572962.
JD283813 - Sequence 264837 from Patent EP1572962.
JD561671 - Sequence 542695 from Patent EP1572962.
JD566331 - Sequence 547355 from Patent EP1572962.
BC040361 - Homo sapiens nuclear receptor interacting protein 1, mRNA (cDNA clone MGC:9257 IMAGE:3918685), complete cds.
JD091356 - Sequence 72380 from Patent EP1572962.
JD496158 - Sequence 477182 from Patent EP1572962.
JD356938 - Sequence 337962 from Patent EP1572962.
JD183007 - Sequence 164031 from Patent EP1572962.
JD037847 - Sequence 18871 from Patent EP1572962.
DQ891180 - Synthetic construct clone IMAGE:100003810; FLH169902.01X; RZPDo839H0596D nuclear receptor interacting protein 1 (NRIP1) gene, encodes complete protein.
KJ897814 - Synthetic construct Homo sapiens clone ccsbBroadEn_07208 NRIP1 gene, encodes complete protein.
DQ894362 - Synthetic construct Homo sapiens clone IMAGE:100008822; FLH169898.01L; RZPDo839H0595D nuclear receptor interacting protein 1 (NRIP1) gene, encodes complete protein.
AB385193 - Synthetic construct DNA, clone: pF1KB9101, Homo sapiens NRIP1 gene for nuclear receptor-interacting protein 1, complete cds, without stop codon, in Flexi system.
CU691868 - Synthetic construct Homo sapiens gateway clone IMAGE:100020551 5' read NRIP1 mRNA.
JD052594 - Sequence 33618 from Patent EP1572962.
JD315104 - Sequence 296128 from Patent EP1572962.
JD129607 - Sequence 110631 from Patent EP1572962.
JD193613 - Sequence 174637 from Patent EP1572962.
JD444277 - Sequence 425301 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_carm-erPathway - CARM1 and Regulation of the Estrogen Receptor
h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)

Reactome (by CSHL, EBI, and GO)

Protein P48552 (Reactome details) participates in the following event(s):

R-HSA-1368087 RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene
R-HSA-5663273 RORA, EP300, PPARGC1A bind NR1D1 gene
R-HSA-400253 Circadian Clock
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-8939211 ESR-mediated signaling
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000318948.1, ENST00000318948.2, ENST00000318948.3, ENST00000318948.4, ENST00000318948.5, ENST00000318948.6, NM_003489, NRIP1_HUMAN, P48552, Q8IWE8, uc317qof.1, uc317qof.2
UCSC ID: ENST00000318948.7_7
RefSeq Accession: NM_003489.4
Protein: P48552 (aka NRIP1_HUMAN or RI14_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.