Human Gene NSG1 (ENST00000621129.5_4) from GENCODE V47lift37
  Description: neuronal vesicle trafficking associated 1, transcript variant 1 (from RefSeq NM_014392.5)
Gencode Transcript: ENST00000621129.5_4
Gencode Gene: ENSG00000168824.15_10
Transcript (Including UTRs)
   Position: hg19 chr4:4,388,829-4,420,785 Size: 31,957 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr4:4,389,357-4,419,162 Size: 29,806 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:4,388,829-4,420,785)mRNA (may differ from genome)Protein (185 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
OMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NSG1_HUMAN
DESCRIPTION: RecName: Full=Neuron-specific protein family member 1; AltName: Full=Brain neuron cytoplasmic protein 1;
SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein (Potential).
SIMILARITY: Belongs to the NSG family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -48.5098-0.495 Picture PostScript Text
3' UTR -495.801623-0.305 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009431 - D1-dopamine_rcpt_interact

Pfam Domains:
PF06387 - D1 dopamine receptor-interacting protein (calcyon)

ModBase Predicted Comparative 3D Structure on P42857
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0032051 clathrin light chain binding

Biological Process:
GO:0001881 receptor recycling
GO:0001921 positive regulation of receptor recycling
GO:0006915 apoptotic process
GO:0007212 dopamine receptor signaling pathway
GO:0016197 endosomal transport
GO:0042982 amyloid precursor protein metabolic process
GO:0048268 clathrin coat assembly
GO:0098814 spontaneous synaptic transmission
GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane
GO:0099627 neurotransmitter receptor cycle
GO:0099630 postsynaptic neurotransmitter receptor cycle
GO:1900271 regulation of long-term synaptic potentiation

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016328 lateral plasma membrane
GO:0030425 dendrite
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0031901 early endosome membrane
GO:0031902 late endosome membrane
GO:0032580 Golgi cisterna membrane
GO:0032585 multivesicular body membrane
GO:0032588 trans-Golgi network membrane
GO:0036477 somatodendritic compartment
GO:0042995 cell projection
GO:0043202 lysosomal lumen
GO:0045211 postsynaptic membrane
GO:0055038 recycling endosome membrane
GO:0098845 postsynaptic endosome


-  Descriptions from all associated GenBank mRNAs
  AK094573 - Homo sapiens cDNA FLJ37254 fis, clone BRAMY2008583, highly similar to Neuron-specific protein family member 1.
BC034227 - Homo sapiens DNA segment on chromosome 4 (unique) 234 expressed sequence, mRNA (cDNA clone MGC:39635 IMAGE:5265974), complete cds.
AK125172 - Homo sapiens cDNA FLJ43182 fis, clone FCBBF3018453, highly similar to Neuron-specific protein family member 1.
AX775767 - Sequence 37 from Patent WO03048202.
BC001745 - Homo sapiens DNA segment on chromosome 4 (unique) 234 expressed sequence, mRNA (cDNA clone MGC:3328 IMAGE:3510777), complete cds.
AK312288 - Homo sapiens cDNA, FLJ92590, Homo sapiens DNA segment on chromosome 4 (unique) 234 expressed sequence (D4S234E), mRNA.
AK299657 - Homo sapiens cDNA FLJ52070 complete cds, highly similar to Neuron-specific protein family member 1.
AK301911 - Homo sapiens cDNA FLJ52071 complete cds, moderately similar to Neuron-specific protein family member 1.
AB463929 - Synthetic construct DNA, clone: pF1KB8218, Homo sapiens NSG1 gene for Neuron-specific protein family member 1, without stop codon, in Flexi system.
CU674858 - Synthetic construct Homo sapiens gateway clone IMAGE:100017992 5' read D4S234E mRNA.
KJ893592 - Synthetic construct Homo sapiens clone ccsbBroadEn_02986 D4S234E gene, encodes complete protein.
AK125065 - Homo sapiens cDNA FLJ43075 fis, clone BRTHA3014908.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DXC5, D4S234 , ENST00000621129.1, ENST00000621129.2, ENST00000621129.3, ENST00000621129.4, NEEP21 , NM_014392, NSG1 , NSG1_HUMAN, P42857, Q49AQ1, uc327tlg.1, uc327tlg.2
UCSC ID: ENST00000621129.5_4
RefSeq Accession: NM_014392.5
Protein: P42857 (aka NSG1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.