Human Gene NTPCR (ENST00000366627.4_1) from GENCODE V47lift37
  Description: nucleoside-triphosphatase, cancer-related (from HGNC NTPCR)
Gencode Transcript: ENST00000366627.4_1
Gencode Gene: ENSG00000135778.12_7
Transcript (Including UTRs)
   Position: hg19 chr1:233,086,386-233,113,274 Size: 26,889 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr1:233,086,457-233,112,270 Size: 25,814 Coding Exon Count: 5 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:233,086,386-233,113,274)mRNA (may differ from genome)Protein (228 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsHGNC
MGIPubMedUniProtKB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.27 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 64.86 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.8071-0.082 Picture PostScript Text
3' UTR -356.901004-0.355 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003593 - AAA+_ATPase
IPR004948 - Nuc-triphosphatase_THEP1

Pfam Domains:
PF03266 - NTPase

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases
53795 - PEP carboxykinase-like

ModBase Predicted Comparative 3D Structure on Q5TDF0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0098519 nucleotide phosphatase activity, acting on free nucleotides

Biological Process:
GO:0016311 dephosphorylation


-  Descriptions from all associated GenBank mRNAs
  AK316591 - Homo sapiens cDNA, FLJ95865.
AK311229 - Homo sapiens cDNA, FLJ18271.
BC005102 - Homo sapiens chromosome 1 open reading frame 57, mRNA (cDNA clone MGC:13186 IMAGE:3619026), complete cds.
LF384502 - JP 2014500723-A/192005: Polycomb-Associated Non-Coding RNAs.
JD135430 - Sequence 116454 from Patent EP1572962.
AF416713 - Homo sapiens clone 2 unknown mRNA.
JD185113 - Sequence 166137 from Patent EP1572962.
BX537541 - Homo sapiens mRNA; cDNA DKFZp686C198 (from clone DKFZp686C198).
LF375391 - JP 2014500723-A/182894: Polycomb-Associated Non-Coding RNAs.
MA620079 - JP 2018138019-A/192005: Polycomb-Associated Non-Coding RNAs.
MA610968 - JP 2018138019-A/182894: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: AK316591, C1orf57 , ENST00000366627.1, ENST00000366627.2, ENST00000366627.3, hCG_15829 , NTPCR , Q5TDF0, Q5TDF0_HUMAN, uc318fga.1
UCSC ID: ENST00000366627.4_1
RefSeq Accession: NM_032324.3
Protein: Q5TDF0

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.