ID:NUDC_HUMAN DESCRIPTION: RecName: Full=Nuclear migration protein nudC; AltName: Full=Nuclear distribution protein C homolog; FUNCTION: Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation. SUBUNIT: Binds PLK1. Binds PAFAH1B1 (By similarity). Part of a complex containing PLK1, NUDC, dynein and dynactin. INTERACTION: P52429:DGKE; NbExp=1; IntAct=EBI-357298, EBI-1057499; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Nucleus. Note=In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear, in a punctate pattern. TISSUE SPECIFICITY: Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart. INDUCTION: Up-regulated in actively dividing hematopoietic precursor cells. Up-regulated in cultured erythroleukemia TF-1 cells by granulocyte-macrophage colony-stimulating factor. Strongly down-regulated during maturation of erythroid precursor cells. PTM: Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-274 and Ser-326 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases. SIMILARITY: Belongs to the nudC family. SIMILARITY: Contains 1 CS domain. SEQUENCE CAUTION: Sequence=BAA76628.1; Type=Frameshift; Positions=140, 231, 273; Sequence=CAI13560.1; Type=Erroneous gene model prediction; Sequence=CAI13563.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y266
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC007280 - Homo sapiens nuclear distribution gene C homolog (A. nidulans), mRNA (cDNA clone MGC:15624 IMAGE:3343588), complete cds. BC015153 - Homo sapiens nuclear distribution gene C homolog (A. nidulans), mRNA (cDNA clone MGC:10006 IMAGE:3883328), complete cds. AL136725 - Homo sapiens mRNA; cDNA DKFZp566P0446 (from clone DKFZp566P0446). AF125465 - Homo sapiens nuclear distribution protein (NUDC) mRNA, complete cds. AF100760 - Homo sapiens MNUDC protein mRNA, complete cds. AF086922 - Homo sapiens SIG-92 mRNA, complete cds. BC021139 - Homo sapiens nuclear distribution gene C homolog (A. nidulans), mRNA (cDNA clone MGC:32082 IMAGE:4871007), complete cds. AF241788 - Homo sapiens NPD011 (NPD011) mRNA, complete cds. AB019408 - Homo sapiens mRNA, expressed in fibroblasts of periodontal ligament, complete cds, clone:PDL-48. BC006147 - Homo sapiens nuclear distribution gene C homolog (A. nidulans), mRNA (cDNA clone MGC:13100 IMAGE:3954220), complete cds. BC003132 - Homo sapiens nuclear distribution gene C homolog (A. nidulans), mRNA (cDNA clone MGC:3526 IMAGE:2958251), complete cds. AF130736 - Homo sapiens nuclear distribution protein C homolog (NUDC) mRNA, complete cds. BC002399 - Homo sapiens nuclear distribution gene C homolog (A. nidulans), mRNA (cDNA clone MGC:8497 IMAGE:2822167), complete cds. AM392722 - Synthetic construct Homo sapiens clone IMAGE:100002449 for hypothetical protein (NUDC gene). AM393251 - Synthetic construct Homo sapiens clone IMAGE:100002450 for hypothetical protein (NUDC gene). AB463146 - Synthetic construct DNA, clone: pF1KB8625, Homo sapiens NUDC gene for nuclear distribution gene C homolog, without stop codon, in Flexi system. KJ898275 - Synthetic construct Homo sapiens clone ccsbBroadEn_07669 NUDC gene, encodes complete protein. JD461768 - Sequence 442792 from Patent EP1572962. JD519579 - Sequence 500603 from Patent EP1572962. JD294601 - Sequence 275625 from Patent EP1572962. JD120829 - Sequence 101853 from Patent EP1572962. JD166824 - Sequence 147848 from Patent EP1572962. JD475772 - Sequence 456796 from Patent EP1572962. JD204146 - Sequence 185170 from Patent EP1572962. JD111102 - Sequence 92126 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9Y266 (Reactome details) participates in the following event(s):
R-HSA-156682 Regulation of NUDC by phosphorylation R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-68884 Mitotic Telophase/Cytokinesis R-HSA-68886 M Phase R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-69278 Cell Cycle (Mitotic) R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-195258 RHO GTPase Effectors R-HSA-1640170 Cell Cycle R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-194315 Signaling by Rho GTPases R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-162582 Signal Transduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
