Human Gene NUPR1 (ENST00000324873.8_7) from GENCODE V47lift37
  Description: nuclear protein 1, transcriptional regulator, transcript variant 2 (from RefSeq NM_012385.3)
Gencode Transcript: ENST00000324873.8_7
Gencode Gene: ENSG00000176046.9_9
Transcript (Including UTRs)
   Position: hg19 chr16:28,544,029-28,550,295 Size: 6,267 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr16:28,549,340-28,550,228 Size: 889 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:28,544,029-28,550,295)mRNA (may differ from genome)Protein (82 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NUPR1_HUMAN
DESCRIPTION: RecName: Full=Nuclear protein 1; AltName: Full=Candidate of metastasis 1; AltName: Full=Protein p8;
FUNCTION: Could participate in the response to proapoptotic stimuli and promotes cellular growth in a way that helps the tissue counteract diverse injuries. May contribute to the metastatic phenotype.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Highly expressed in pancreas.
PTM: Phosphorylated.
SIMILARITY: Belongs to the NUPR family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NUPR1
Diseases sorted by gene-association score: pancreatic ductal adenocarcinoma (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 293.15 RPKM in Thyroid
Total median expression: 4734.63 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.9067-0.118 Picture PostScript Text
3' UTR -2128.404975-0.428 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018792 - Nuclear_phosphoprot_p8_DNA-bd

Pfam Domains:
PF10195 - DNA-binding nuclear phosphoprotein p8

ModBase Predicted Comparative 3D Structure on O60356
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding

Biological Process:
GO:0002526 acute inflammatory response
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006473 protein acetylation
GO:0008283 cell proliferation
GO:0008584 male gonad development
GO:0009636 response to toxic substance
GO:0031401 positive regulation of protein modification process
GO:0035914 skeletal muscle cell differentiation
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043065 positive regulation of apoptotic process
GO:0045786 negative regulation of cell cycle
GO:0048147 negative regulation of fibroblast proliferation
GO:0065003 macromolecular complex assembly
GO:2000194 regulation of female gonad development

Cellular Component:
GO:0005634 nucleus
GO:0005829 cytosol
GO:0032993 protein-DNA complex


-  Descriptions from all associated GenBank mRNAs
  DQ581449 - Homo sapiens piRNA piR-49561, complete sequence.
JD105968 - Sequence 86992 from Patent EP1572962.
JD517748 - Sequence 498772 from Patent EP1572962.
JD533844 - Sequence 514868 from Patent EP1572962.
JD179298 - Sequence 160322 from Patent EP1572962.
JD308229 - Sequence 289253 from Patent EP1572962.
JD346472 - Sequence 327496 from Patent EP1572962.
JD311989 - Sequence 293013 from Patent EP1572962.
JD181048 - Sequence 162072 from Patent EP1572962.
JD346474 - Sequence 327498 from Patent EP1572962.
JD311990 - Sequence 293014 from Patent EP1572962.
JD566901 - Sequence 547925 from Patent EP1572962.
JD388318 - Sequence 369342 from Patent EP1572962.
JD321126 - Sequence 302150 from Patent EP1572962.
JD041379 - Sequence 22403 from Patent EP1572962.
JD169359 - Sequence 150383 from Patent EP1572962.
JD529232 - Sequence 510256 from Patent EP1572962.
JD321125 - Sequence 302149 from Patent EP1572962.
JD041378 - Sequence 22402 from Patent EP1572962.
JD169358 - Sequence 150382 from Patent EP1572962.
JD529231 - Sequence 510255 from Patent EP1572962.
JD557385 - Sequence 538409 from Patent EP1572962.
JD430204 - Sequence 411228 from Patent EP1572962.
JD326825 - Sequence 307849 from Patent EP1572962.
JD201300 - Sequence 182324 from Patent EP1572962.
JD247781 - Sequence 228805 from Patent EP1572962.
JD523760 - Sequence 504784 from Patent EP1572962.
JD351833 - Sequence 332857 from Patent EP1572962.
JD472519 - Sequence 453543 from Patent EP1572962.
JD533381 - Sequence 514405 from Patent EP1572962.
JD453143 - Sequence 434167 from Patent EP1572962.
JD199532 - Sequence 180556 from Patent EP1572962.
JD267476 - Sequence 248500 from Patent EP1572962.
JD238467 - Sequence 219491 from Patent EP1572962.
JD135918 - Sequence 116942 from Patent EP1572962.
JD217465 - Sequence 198489 from Patent EP1572962.
JD052733 - Sequence 33757 from Patent EP1572962.
JD194721 - Sequence 175745 from Patent EP1572962.
JD194720 - Sequence 175744 from Patent EP1572962.
JD537328 - Sequence 518352 from Patent EP1572962.
AF069073 - Homo sapiens P8 protein mRNA, complete cds.
AF135266 - Homo sapiens p8 protein homolog (COM1) mRNA, complete cds.
BC002434 - Homo sapiens nuclear protein 1, mRNA (cDNA clone MGC:1991 IMAGE:3347264), complete cds.
JD474336 - Sequence 455360 from Patent EP1572962.
JD480190 - Sequence 461214 from Patent EP1572962.
JD342017 - Sequence 323041 from Patent EP1572962.
JD541002 - Sequence 522026 from Patent EP1572962.
JD175230 - Sequence 156254 from Patent EP1572962.
JD184671 - Sequence 165695 from Patent EP1572962.
JD059435 - Sequence 40459 from Patent EP1572962.
JD387987 - Sequence 369011 from Patent EP1572962.
JD471201 - Sequence 452225 from Patent EP1572962.
JD173598 - Sequence 154622 from Patent EP1572962.
CR542144 - Homo sapiens full open reading frame cDNA clone RZPDo834G0423D for gene P8, p8 protein (candidate of metastasis 1); complete cds, incl. stopcodon.
AK312135 - Homo sapiens cDNA, FLJ92417, highly similar to Homo sapiens p8 protein (candidate of metastasis 1) (P8), mRNA.
KJ893565 - Synthetic construct Homo sapiens clone ccsbBroadEn_02959 NUPR1 gene, encodes complete protein.
BT006896 - Homo sapiens p8 protein (candidate of metastasis 1) mRNA, complete cds.
AB463938 - Synthetic construct DNA, clone: pF1KB8854, Homo sapiens NUPR1 gene for Nuclear protein 1, without stop codon, in Flexi system.
JD409696 - Sequence 390720 from Patent EP1572962.
JD337042 - Sequence 318066 from Patent EP1572962.
JD372405 - Sequence 353429 from Patent EP1572962.
JD065808 - Sequence 46832 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2R5C4, COM1, ENST00000324873.1, ENST00000324873.2, ENST00000324873.3, ENST00000324873.4, ENST00000324873.5, ENST00000324873.6, ENST00000324873.7, NM_012385, NUPR1 , NUPR1_HUMAN, O60356, O60357, Q6FGG3, uc317rtm.1, uc317rtm.2
UCSC ID: ENST00000324873.8_7
RefSeq Accession: NM_012385.3
Protein: O60356 (aka NUPR1_HUMAN or NLN1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.