Human Gene NVL (ENST00000281701.11_11) from GENCODE V47lift37
Description: nuclear VCP like, transcript variant 1 (from RefSeq NM_002533.4)
Gencode Transcript: ENST00000281701.11_11
Gencode Gene: ENSG00000143748.18_14
Transcript (Including UTRs)
Position: hg19 chr1:224,415,047-224,517,874 Size: 102,828 Total Exon Count: 23 Strand: -
Coding Region
Position: hg19 chr1:224,415,328-224,517,829 Size: 102,502 Coding Exon Count: 23
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: NVL_HUMAN
DESCRIPTION: RecName: Full=Nuclear valosin-containing protein-like; Short=NVLp; Short=Nuclear VCP-like protein;
SUBUNIT: Interacts with NCL/nucleolin.SUBCELLULAR LOCATION: Nucleus, nucleolus.TISSUE SPECIFICITY: Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.SIMILARITY: Belongs to the AAA ATPase family.
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR003593 - AAA+_ATPase
IPR003959 - ATPase_AAA_core
IPR003960 - ATPase_AAA_CS
Pfam Domains: PF00004 - ATPase family associated with various cellular activities (AAA)
PF05496 - Holliday junction DNA helicase RuvB P-loop domain
PF07724 - AAA domain (Cdc48 subfamily)
PF07728 - AAA domain (dynein-related subfamily)
PF16725 - Nucleolin binding domain
PF17862 - AAA+ lid domain
SCOP Domains: 52540 - P-loop containing nucleoside triphosphate hydrolases
53795 - PEP carboxykinase-like
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on O15381
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
U68140 - Homo sapiens nuclear VCP-like protein NVLp.2 (NVL.2) mRNA, complete cds.U78772 - Homo sapiens nuclear VCP-like protein NVLp.1 (NVL.1) mRNA, complete cds.BC012105 - Homo sapiens nuclear VCP-like, mRNA (cDNA clone MGC:20090 IMAGE:4636004), complete cds.AK298244 - Homo sapiens cDNA FLJ56121 complete cds, highly similar to Nuclear valosin-containing protein-like.JD022803 - Sequence 3827 from Patent EP1572962.JD556589 - Sequence 537613 from Patent EP1572962.AK297396 - Homo sapiens cDNA FLJ55724 complete cds, highly similar to Nuclear valosin-containing protein-like.JD155012 - Sequence 136036 from Patent EP1572962.AK297070 - Homo sapiens cDNA FLJ56105 complete cds, highly similar to Nuclear valosin-containing protein-like.JD465762 - Sequence 446786 from Patent EP1572962.JD320775 - Sequence 301799 from Patent EP1572962.JF432850 - Synthetic construct Homo sapiens clone IMAGE:100074172 nuclear VCP-like (NVL) gene, encodes complete protein.KJ901612 - Synthetic construct Homo sapiens clone ccsbBroadEn_11006 NVL gene, encodes complete protein.AK298826 - Homo sapiens cDNA FLJ59213 complete cds, highly similar to Nuclear valosin-containing protein-like.BC005897 - Homo sapiens nuclear VCP-like, mRNA (cDNA clone IMAGE:4249184), partial cds.AK293923 - Homo sapiens cDNA FLJ59858 complete cds, moderately similar to Nuclear valosin-containing protein-like.AF401208 - Homo sapiens nuclear VCP-like protein (NVL) mRNA, partial cds.JD074233 - Sequence 55257 from Patent EP1572962.JD328705 - Sequence 309729 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: B4DMC4, B4DP98, ENST00000281701.1, ENST00000281701.10, ENST00000281701.2, ENST00000281701.3, ENST00000281701.4, ENST00000281701.5, ENST00000281701.6, ENST00000281701.7, ENST00000281701.8, ENST00000281701.9, NM_002533, NVL , NVL2 , NVL_HUMAN, O15381, Q96EM7, uc317jxa.1, uc317jxa.2UCSC ID: ENST00000281701.11_11RefSeq Accession: NM_002533.4
Protein: O15381
(aka NVL_HUMAN)
Gene Model Information
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.