ID:OAS3_HUMAN DESCRIPTION: RecName: Full=2'-5'-oligoadenylate synthase 3; Short=(2-5')oligo(A) synthase 3; Short=2-5A synthase 3; EC=2.7.7.-; AltName: Full=p100 OAS; Short=p100OAS; FUNCTION: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV). CATALYTIC ACTIVITY: Binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. COFACTOR: Magnesium (Potential). ENZYME REGULATION: Produced as a latent enzyme which is activated by dsRNA generated during the course of viral infection. The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2'-hydroxyl group is tolerated. ssRNA or dsDNA do not act as activators. SUBUNIT: Monomer. INTERACTION: Q7L2E3:DHX30; NbExp=2; IntAct=EBI-6115729, EBI-1211456; P56537:EIF6; NbExp=2; IntAct=EBI-6115729, EBI-372243; Q8IY81:FTSJ3; NbExp=2; IntAct=EBI-6115729, EBI-744088; Q12894:IFRD2; NbExp=2; IntAct=EBI-6115729, EBI-6115935; Q7Z434:MAVS; NbExp=2; IntAct=EBI-6115729, EBI-995373; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Present at high level in placenta trophoblast. INDUCTION: By type I interferon (IFN) and viruses. SIMILARITY: Belongs to the 2-5A synthase family. SEQUENCE CAUTION: Sequence=AAD28543.1; Type=Frameshift; Positions=394, 398;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y6K5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
