Human Gene OAZ1 (ENST00000582888.8_7) from GENCODE V47lift37
  Description: ornithine decarboxylase antizyme 1, transcript variant 2 (from RefSeq NM_001301020.1)
Gencode Transcript: ENST00000582888.8_7
Gencode Gene: ENSG00000104904.13_16
Transcript (Including UTRs)
   Position: hg19 chr19:2,269,533-2,273,330 Size: 3,798 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr19:2,269,598-2,273,107 Size: 3,510 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:2,269,533-2,273,330)mRNA (may differ from genome)Protein (226 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: J3QQY4_HUMAN
DESCRIPTION: SubName: Full=Ornithine decarboxylase antizyme 1;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 926.84 RPKM in Whole Blood
Total median expression: 15373.35 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -23.3065-0.358 Picture PostScript Text
3' UTR -69.70223-0.313 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016181 - Acyl_CoA_acyltransferase
IPR002993 - ODC_AZ

Pfam Domains:
PF02100 - Ornithine decarboxylase antizyme

SCOP Domains:
55729 - Acyl-CoA N-acyltransferases (Nat)

ModBase Predicted Comparative 3D Structure on J3QQY4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008073 ornithine decarboxylase inhibitor activity

Biological Process:
GO:0006595 polyamine metabolic process
GO:0043086 negative regulation of catalytic activity

Cellular Component:
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  KJ901613 - Synthetic construct Homo sapiens clone ccsbBroadEn_11007 OAZ1 gene, encodes complete protein.
AK307221 - Homo sapiens cDNA, FLJ97169.
LF210705 - JP 2014500723-A/18208: Polycomb-Associated Non-Coding RNAs.
LF340482 - JP 2014500723-A/147985: Polycomb-Associated Non-Coding RNAs.
AK309122 - Homo sapiens cDNA, FLJ99163.
BC042364 - Homo sapiens cDNA clone IMAGE:5277710, containing frame-shift errors.
BC100291 - Homo sapiens cDNA clone IMAGE:6139660, containing frame-shift errors.
BC013037 - Homo sapiens cDNA clone IMAGE:3536380, containing frame-shift errors.
D78361 - Homo sapiens mRNA for ornithine decarboxylase antizyme.
BC010063 - Homo sapiens, ornithine decarboxylase antizyme 1, clone IMAGE:3957075, mRNA.
BC081537 - Homo sapiens cDNA clone IMAGE:30524527, containing frame-shift errors.
BC007247 - Homo sapiens cDNA clone IMAGE:2966822, containing frame-shift errors.
D87914 - Homo sapiens hAZ-brain mRNA for ornithine decarboxylase antizyme, complete cds.
BC053360 - Homo sapiens cDNA clone IMAGE:6011374, containing frame-shift errors.
JD462612 - Sequence 443636 from Patent EP1572962.
BC055397 - Homo sapiens cDNA clone IMAGE:5207921, containing frame-shift errors.
U09202 - Human ornithine decarboxylase antizyme (Oaz) mRNA, complete cds.
BC093652 - Homo sapiens ornithine decarboxylase antizyme 1, mRNA (cDNA clone MGC:120687 IMAGE:7939497), complete cds.
BC112133 - Homo sapiens ornithine decarboxylase antizyme 1, mRNA (cDNA clone MGC:138338 IMAGE:8327601), complete cds.
HQ258025 - Synthetic construct Homo sapiens clone IMAGE:100072334 Unknown protein gene, encodes complete protein.
BC035151 - Homo sapiens cDNA clone IMAGE:5265016, containing frame-shift errors.
AF090094 - UNVERIFIED: Homo sapiens clone IMAGE 172979.
LF340481 - JP 2014500723-A/147984: Polycomb-Associated Non-Coding RNAs.
LF340480 - JP 2014500723-A/147983: Polycomb-Associated Non-Coding RNAs.
JD080570 - Sequence 61594 from Patent EP1572962.
JD280169 - Sequence 261193 from Patent EP1572962.
JD325063 - Sequence 306087 from Patent EP1572962.
MA446282 - JP 2018138019-A/18208: Polycomb-Associated Non-Coding RNAs.
MA576059 - JP 2018138019-A/147985: Polycomb-Associated Non-Coding RNAs.
MA576058 - JP 2018138019-A/147984: Polycomb-Associated Non-Coding RNAs.
MA576057 - JP 2018138019-A/147983: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000582888.1, ENST00000582888.2, ENST00000582888.3, ENST00000582888.4, ENST00000582888.5, ENST00000582888.6, ENST00000582888.7, J3QQY4, J3QQY4_HUMAN, NM_001301020, OAZ1 , uc326lss.1, uc326lss.2
UCSC ID: ENST00000582888.8_7
RefSeq Accession: NM_001301020.1
Protein: J3QQY4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.