Human Gene OCIAD2 (ENST00000508632.6_7) from GENCODE V47lift37
  Description: OCIA domain containing 2, transcript variant 4 (from RefSeq NM_001286774.2)
Gencode Transcript: ENST00000508632.6_7
Gencode Gene: ENSG00000145247.12_13
Transcript (Including UTRs)
   Position: hg19 chr4:48,887,036-48,908,791 Size: 21,756 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr4:48,887,501-48,906,566 Size: 19,066 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:48,887,036-48,908,791)mRNA (may differ from genome)Protein (154 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: OCAD2_HUMAN
DESCRIPTION: RecName: Full=OCIA domain-containing protein 2; AltName: Full=Ovarian carcinoma immunoreactive antigen-like protein;
SUBCELLULAR LOCATION: Endosome (Probable).
SIMILARITY: Contains 1 OCIA domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: OCIAD2
Diseases sorted by gene-association score: ovarian mucinous neoplasm (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 38.99 RPKM in Kidney - Cortex
Total median expression: 571.40 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -56.60179-0.316 Picture PostScript Text
3' UTR -140.80465-0.303 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009764 - OCIA

Pfam Domains:
PF07051 - Ovarian carcinoma immunoreactive antigen (OCIA)

ModBase Predicted Comparative 3D Structure on Q56VL3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005768 endosome


-  Descriptions from all associated GenBank mRNAs
  AK298305 - Homo sapiens cDNA FLJ50823 complete cds, highly similar to Homo sapiens OCIA domain containing 2 (OCIAD2), transcript variant 1, mRNA.
CR749310 - Homo sapiens mRNA; cDNA DKFZp686C03164 (from clone DKFZp686C03164).
BC032808 - Homo sapiens OCIA domain containing 2, mRNA (cDNA clone MGC:45416 IMAGE:4454708), complete cds.
KJ900143 - Synthetic construct Homo sapiens clone ccsbBroadEn_09537 OCIAD2 gene, encodes complete protein.
AY472117 - Homo sapiens ovarian carcinoma immunoreactive antigen-like protein mRNA, complete cds.
JD091320 - Sequence 72344 from Patent EP1572962.
JD184674 - Sequence 165698 from Patent EP1572962.
JD020544 - Sequence 1568 from Patent EP1572962.
JD374288 - Sequence 355312 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DPE7, ENST00000508632.1, ENST00000508632.2, ENST00000508632.3, ENST00000508632.4, ENST00000508632.5, NM_001286774, OCAD2_HUMAN, Q56VL3, Q8N544, uc323dyi.1, uc323dyi.2
UCSC ID: ENST00000508632.6_7
RefSeq Accession: NM_001014446.3
Protein: Q56VL3 (aka OCAD2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.