The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q02218
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity GO:0016491 oxidoreductase activity GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GO:0030976 thiamine pyrophosphate binding GO:0031072 heat shock protein binding GO:0034602 oxoglutarate dehydrogenase (NAD+) activity GO:0046872 metal ion binding GO:0051087 chaperone binding
Biological Process: GO:0006091 generation of precursor metabolites and energy GO:0006096 glycolytic process GO:0006099 tricarboxylic acid cycle GO:0006103 2-oxoglutarate metabolic process GO:0006104 succinyl-CoA metabolic process GO:0006734 NADH metabolic process GO:0008152 metabolic process GO:0021695 cerebellar cortex development GO:0021756 striatum development GO:0021766 hippocampus development GO:0021794 thalamus development GO:0021860 pyramidal neuron development GO:0022028 tangential migration from the subventricular zone to the olfactory bulb GO:0055114 oxidation-reduction process GO:0061034 olfactory bulb mitral cell layer development
BioCyc Knowledge Library PWY-5084 - 2-oxoglutarate decarboxylation to succinyl-CoA PWY66-398 - TCA cycle PWY66-407 - superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
Reactome (by CSHL, EBI, and GO)
Protein Q02218 (Reactome details) participates in the following event(s):
R-HSA-6792572 LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs R-HSA-71037 alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ R-HSA-71401 alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ R-HSA-389661 Glyoxylate metabolism and glycine degradation R-HSA-71064 Lysine catabolism R-HSA-71403 Citric acid cycle (TCA cycle) R-HSA-71291 Metabolism of nitrogenous molecules R-HSA-6788656 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle R-HSA-1430728 Metabolism R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
