Human Gene OMP (ENST00000529803.1_4) from GENCODE V47lift37
  Description: olfactory marker protein (from RefSeq NM_006189.1)
Gencode Transcript: ENST00000529803.1_4
Gencode Gene: ENSG00000254550.1_8
Transcript (Including UTRs)
   Position: hg19 chr11:76,813,886-76,814,377 Size: 492 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr11:76,813,886-76,814,377 Size: 492 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:76,813,886-76,814,377)mRNA (may differ from genome)Protein (163 aa)
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BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: OMP_HUMAN
DESCRIPTION: RecName: Full=Olfactory marker protein; AltName: Full=Olfactory neuronal-specific protein;
FUNCTION: May act as a modulator of the olfactory signal- transduction cascade.
SUBUNIT: Interacts with BEX1 and BEX2 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Uniquely associated with mature olfactory receptor neurons.
SIMILARITY: Belongs to the olfactory marker protein family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: OMP
Diseases sorted by gene-association score: epiglottitis (24), haemophilus influenzae (19), typhoid fever (14), neisseria meningitidis infection (14), cranial nerve malignant neoplasm (13), reactive arthritis (10), olfactory nerve neoplasm (9), legionnaires' disease (7), usher syndrome (4), meningitis (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.01 RPKM in Colon - Transverse
Total median expression: 4.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009103 - Olfactory_marker

Pfam Domains:
PF06554 - Olfactory marker protein

SCOP Domains:
63697 - Olfactory marker protein

ModBase Predicted Comparative 3D Structure on P47874
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity

Biological Process:
GO:0007165 signal transduction
GO:0007268 chemical synaptic transmission
GO:0007608 sensory perception of smell
GO:0022008 neurogenesis
GO:0050896 response to stimulus

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030424 axon
GO:0043025 neuronal cell body


-  Descriptions from all associated GenBank mRNAs
  LF207780 - JP 2014500723-A/15283: Polycomb-Associated Non-Coding RNAs.
CU686775 - Synthetic construct Homo sapiens gateway clone IMAGE:100022606 5' read OMP mRNA.
HQ448416 - Synthetic construct Homo sapiens clone IMAGE:100071843; CCSB013798_02 olfactory marker protein (OMP) gene, encodes complete protein.
KJ891725 - Synthetic construct Homo sapiens clone ccsbBroadEn_01119 OMP gene, encodes complete protein.
BC069115 - Homo sapiens olfactory marker protein, mRNA (cDNA clone MGC:95394 IMAGE:7216933), complete cds.
BC069365 - Homo sapiens olfactory marker protein, mRNA (cDNA clone MGC:96897 IMAGE:7262106), complete cds.
MA443357 - JP 2018138019-A/15283: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_006189, OMP_HUMAN, P47874, Q562G2, uc324god.1, uc324god.2
UCSC ID: ENST00000529803.1_4
RefSeq Accession: NM_006189.1
Protein: P47874 (aka OMP_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.