ID:OPSR_HUMAN DESCRIPTION: RecName: Full=Long-wave-sensitive opsin 1; AltName: Full=Red cone photoreceptor pigment; AltName: Full=Red-sensitive opsin; Short=ROP; FUNCTION: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. BIOPHYSICOCHEMICAL PROPERTIES: Absorption: Abs(max)=560 nm; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: The three color pigments are found in the cone photoreceptor cells. PTM: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region. DISEASE: Defects in OPN1LW are the cause of partial colorblindness protan series (CBP) [MIM:303900]; also known as protanopia. DISEASE: Defects in OPN1LW are a cause of blue cone monochromacy (BCM) [MIM:303700]. A rare X-linked congenital stationary cone dysfunction syndrome characterized by the absence of functional long wavelength-sensitive and medium wavelength-sensitive cones in the retina. Color discrimination is severely impaired from birth, and vision is derived from the remaining preserved blue (S) cones and rod photoreceptors. BCM typically presents with reduced visual acuity, pendular nystagmus, and photophobia. Patients often have myopia. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. WEB RESOURCE: Name=Mutations of the color pigment genes; Note=Retina International's Scientific Newsletter; URL="http://www.retina-international.org/files/sci-news/cppmut.htm"; WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/OPN1LW";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P04000
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
