Human Gene OPRK1 (ENST00000265572.8_7) from GENCODE V47lift37

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Description: opioid receptor kappa 1, transcript variant 1 (from RefSeq NM_000912.5)
Gencode Transcript: ENST00000265572.8_7
Gencode Gene: ENSG00000082556.14_12
Transcript (Including UTRs)
Position: hg19 chr8:54,138,284-54,164,197 Size: 25,914 Total Exon Count: 4 Strand: -
Coding Region
Position: hg19 chr8:54,141,857-54,163,597 Size: 21,741 Coding Exon Count: 3

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr8:54,138,284-54,164,197)			mRNA (may differ from genome)		Protein (380 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Human Cortex Gene Expression	Malacards	MGI	OMIM	PubMed
Reactome	UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: OPRK_HUMAN DESCRIPTION: RecName: Full=Kappa-type opioid receptor; Short=K-OR-1; Short=KOR-1; FUNCTION: Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions. SUBUNIT: Interacts with SLC9A3R1. Interacts with GABARAPL1. INTERACTION: Q9H0R8:GABARAPL1; NbExp=5; IntAct=EBI-925028, EBI-3464833; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. WEB RESOURCE: Name=Wikipedia; Note=Kappa opioid receptor entry; URL="http://en.wikipedia.org/wiki/Kappa_opioid_receptor";

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: OPRK1 Diseases sorted by gene-association score: alcohol dependence (13), morphine dependence (13), neonatal abstinence syndrome (11), drug dependence (11), cocaine dependence (11), opiate dependence (10), fuchs' heterochromic uveitis (7), substance dependence (7), uremic pruritus (7), phobic disorder (7), agoraphobia (5), pain agnosia (5), agnosia (5)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D019900 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer D002077 Butorphanol D004399 Dynorphins C051844 norbinaltorphimine D001564 Benzo(a)pyrene D002047 Buprenorphine D003042 Cocaine D016314 Ethylketocyclazocine C027247 MR 2266 D009020 Morphine D009270 Naloxone D009638 Norepinephrine D010126 Ozone C111212 TRK 820 C045444 U 69593 D015054 Zymosan C027248 bremazocine C084603 cyclorphan C502814 dynorphin A-(1-11)-NH2, Nalpha-benzylTyr(1)-cyclo(Asp(5)-Dap(8))- C067110 enadoline C499148 17,17'-bis(cyclopropylmethyl)-6,6',7,7'-tetrahydro-4,5-4',5'-diepoxy-6,6'-(benzylimino)(7,7'-bimorphinan)-3,3',14,14'-tetrol D015081 2-Naphthylamine C017487 2-mercaptoacetate C433814 7-hydroxy-N-(1-((4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl)methyl)-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide C551454 7-hydroxy-N-(1-((4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)methyl)-2-methylbutyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide dihydrochloride D000081 Acetamides D000643 Ammonium Chloride D001464 Barium D002104 Cadmium D019256 Cadmium Chloride D002713 Chlorine D003061 Codeine D003300 Copper D003496 Cyclazocine D003513 Cycloheximide D003915 Dextromethorphan D011431 Dextropropoxyphene D003917 Dextrorphan D003993 Dibutyl Phthalate D004298 Dopamine C061285 E 2078 D020875 Enkephalin, Ala(2)-MePhe(4)-Gly(5)- D020881 Enkephalin, D-Penicillamine (2,5)- D004837 Epinephrine D000431 Ethanol D006853 Hydrocodone C058468 ICI 199441 D007050 Ibogaine D007977 Levallorphan D007981 Levorphanol D008070 Lipopolysaccharides D008274 Magnesium D008345 Manganese D008614 Meperidine D008627 Mercuric Chloride D008628 Mercury D008691 Methadone D008692 Methadyl Acetate D008727 Methotrexate C551455 N-(1-((4-(3-carbamoylphenyl)-3,4-dimethylpiperidin-1-yl)methyl)-2-methylpropyl)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide C440388 N-(3-iodoprop-(2)-enyl) C440369 N-propargyl D009266 Nalbuphine D009271 Naltrexone D009538 Nicotine D010098 Oxycodone C054718 PD 117302 D010423 Pentazocine D010433 Pentylenetetrazole D010852 Picrotoxin D010862 Pilocarpine D010936 Plant Extracts C098221 RP 60180 D012701 Serotonin D013749 Tetrachlorodibenzodioxin D013759 Tetrahydrocannabinol D013876 Thiophenes D014147 Tramadol D014212 Tretinoin C042552 acenaphthene C470200 arodyn C044130 dextrallorphan C067749 fedotozine C010238 fomepizole C106014 gedunin C012395 ketazocine C038981 nalmefene C058380 naloxone benzoylhydrazone C094385 noribogaine C090499 salvinorin A C051272 spiradoline C523979 tapentadol C035470 tifluadom C050414 tripterine

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 2.27 RPKM in Brain - Nucleus accumbens (basal ganglia) Total median expression: 10.90 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-113.20	238	-0.476	Picture	PostScript	Text
3' UTR	-1022.10	3573	-0.286	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR000452 - Kappa_opi_rcpt
IPR001418 - Opioid_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx
PF10323 - Serpentine type 7TM GPCR chemoreceptor Srv
PF10328 - Serpentine type 7TM GPCR chemoreceptor Srx

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2A0D - Model

2IQN - Model

4DJH - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on P41145


Front	Top	Side

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Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0004871 signal transducer activity GO:0004930 G-protein coupled receptor activity GO:0004985 opioid receptor activity GO:0005515 protein binding GO:0033612 receptor serine/threonine kinase binding GO:0038048 dynorphin receptor activity GO:0042923 neuropeptide binding Biological Process: GO:0006955 immune response GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007218 neuropeptide signaling pathway GO:0007268 chemical synaptic transmission GO:0007600 sensory perception GO:0007610 behavior GO:0007626 locomotory behavior GO:0009314 response to radiation GO:0019233 sensory perception of pain GO:0031635 adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0032868 response to insulin GO:0033603 positive regulation of dopamine secretion GO:0033685 negative regulation of luteinizing hormone secretion GO:0038003 opioid receptor signaling pathway GO:0040017 positive regulation of locomotion GO:0042220 response to cocaine GO:0042711 maternal behavior GO:0042755 eating behavior GO:0043278 response to morphine GO:0043627 response to estrogen GO:0044849 estrous cycle GO:0045471 response to ethanol GO:0046877 regulation of saliva secretion GO:0048148 behavioral response to cocaine GO:0050951 sensory perception of temperature stimulus GO:0051607 defense response to virus GO:0051930 regulation of sensory perception of pain GO:0071222 cellular response to lipopolysaccharide GO:0071333 cellular response to glucose stimulus GO:1900745 positive regulation of p38MAPK cascade GO:1901381 positive regulation of potassium ion transmembrane transport GO:1903937 response to acrylamide GO:1904000 positive regulation of eating behavior GO:1990708 conditioned place preference Cellular Component: GO:0005634 nucleus GO:0005829 cytosol GO:0005886 plasma membrane GO:0005887 integral component of plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane GO:0030425 dendrite GO:0043005 neuron projection GO:0043025 neuronal cell body GO:0043204 perikaryon GO:0043679 axon terminus GO:0045202 synapse

Descriptions from all associated GenBank mRNAs


	AK023198 - Homo sapiens cDNA FLJ13136 fis, clone NT2RP3003139. BC099912 - Homo sapiens opioid receptor, kappa 1, mRNA (cDNA clone MGC:104656 IMAGE:30531690), complete cds. AK310407 - Homo sapiens cDNA, FLJ17449. AK310233 - Homo sapiens cDNA, FLJ17275. L37362 - Homo sapiens (clone d2-115) kappa opioid receptor (OPRK1) mRNA, complete cds. AY168006 - Homo sapiens DRG kappa 1 splice variant KOR 1A mRNA, complete cds, alternatively spliced. U11053 - Human kappa opioid receptor (hKOR) mRNA, complete cds. U17298 - Human kappa opioid receptor (hKOR) mRNA, complete cds. AF498922 - Homo sapiens opioid receptor kappa (OPRK1) mRNA, complete cds. EF057067 - Homo sapiens kappa opioid receptor 1 variant-like mRNA, complete sequence. AK313058 - Homo sapiens cDNA, FLJ93535, Homo sapiens opioid receptor, kappa 1 (OPRK1), mRNA. KJ897279 - Synthetic construct Homo sapiens clone ccsbBroadEn_06673 OPRK1 gene, encodes complete protein. AB528953 - Synthetic construct DNA, clone: pF1KB6591, Homo sapiens OPRK1 gene for opioid receptor, kappa 1, without stop codon, in Flexi system. L36130 - Homo sapiens kappa opiate receptor mRNA, partial cds. AY466378 - Homo sapiens kappa opioid receptor (OPRK1) mRNA, 5' UTR and partial cds. MN308224 - Homo sapiens isolate KOR-TV6 opioid receptor kappa 1 (OPRK1) mRNA, partial cds, alternatively spliced. MN308222 - Homo sapiens isolate KOR-TV5A opioid receptor kappa 1 (OPRK1) mRNA, partial cds, alternatively spliced. MN308223 - Homo sapiens isolate KOR-TV5B opioid receptor kappa 1 (OPRK1) mRNA, partial cds, alternatively spliced.

Biochemical and Signaling Pathways


	BioCarta from NCI Cancer Genome Anatomy Project h_dreampathway - Repression of Pain Sensation by the Transcriptional Regulator DREAM Reactome (by CSHL, EBI, and GO) Protein P41145 (Reactome details) participates in the following event(s): R-HSA-374298 Opioid receptors bind opioid peptides R-HSA-749454 The Ligand:GPCR:Gi complex dissociates R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi R-HSA-375276 Peptide ligand-binding receptors R-HSA-418594 G alpha (i) signalling events R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-388396 GPCR downstream signalling R-HSA-500792 GPCR ligand binding R-HSA-372790 Signaling by GPCR R-HSA-162582 Signal Transduction

Other Names for This Gene


	Alternate Gene Symbols: E5RHC9, ENST00000265572.1, ENST00000265572.2, ENST00000265572.3, ENST00000265572.4, ENST00000265572.5, ENST00000265572.6, ENST00000265572.7, NM_000912, OPRK, OPRK_HUMAN, P41145, Q499G4, uc317ici.1, uc317ici.2 UCSC ID: ENST00000265572.8_7 RefSeq Accession: NM_001318497.2 Protein: P41145 (aka OPRK_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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