Human Gene OR8D2 (ENST00000624618.2_6) from GENCODE V47lift37
  Description: olfactory receptor family 8 subfamily D member 2 (from RefSeq NM_001002918.1)
Gencode Transcript: ENST00000624618.2_6
Gencode Gene: ENSG00000279116.3_8
Transcript (Including UTRs)
   Position: hg19 chr11:124,189,158-124,190,093 Size: 936 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr11:124,189,158-124,190,093 Size: 936 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:124,189,158-124,190,093)mRNA (may differ from genome)Protein (311 aa)
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-  Comments and Description Text from UniProtKB
  ID: OR8D2_HUMAN
DESCRIPTION: RecName: Full=Olfactory receptor 8D2; AltName: Full=Olfactory receptor OR11-303; AltName: Full=Olfactory receptor-like protein JCG2;
FUNCTION: Odorant receptor (Potential). May be involved in taste perception.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in the tongue.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); URL="http://bip.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR8D2";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR000725 - Olfact_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF13853 - Olfactory receptor

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q9GZM6
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004984 olfactory receptor activity
GO:0005549 odorant binding

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007608 sensory perception of smell
GO:0050896 response to stimulus
GO:0050911 detection of chemical stimulus involved in sensory perception of smell

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC137043 - Homo sapiens olfactory receptor, family 8, subfamily D, member 2, mRNA (cDNA clone MGC:168662 IMAGE:9021039), complete cds.
BC137045 - Homo sapiens olfactory receptor, family 8, subfamily D, member 2, mRNA (cDNA clone MGC:168664 IMAGE:9021041), complete cds.
AF162668 - Homo sapiens olfactory receptor-like protein JCG2 (JCG2) mRNA, partial cds.
KJ895956 - Synthetic construct Homo sapiens clone ccsbBroadEn_05350 OR8D2 gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9GZM6 (Reactome details) participates in the following event(s):

R-HSA-381750 Olfactory Receptor - G Protein olfactory trimer complex formation
R-HSA-381753 Olfactory Signaling Pathway
R-HSA-418555 G alpha (s) signalling events
R-HSA-388396 GPCR downstream signalling
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B9EH49, ENST00000624618.1, NM_001002918, OR8D2_HUMAN, Q6IFR0, Q9GZM6, uc327wkk.1, uc327wkk.2
UCSC ID: ENST00000624618.2_6
RefSeq Accession: NM_001002918.1
Protein: Q9GZM6 (aka OR8D2_HUMAN or O8D2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.