ID:ORC2_HUMAN DESCRIPTION: RecName: Full=Origin recognition complex subunit 2; FUNCTION: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. SUBUNIT: ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4 (By similarity). Interacts with MCM10. INTERACTION: Q7L590:MCM10; NbExp=5; IntAct=EBI-374957, EBI-374912; P25205:MCM3; NbExp=2; IntAct=EBI-374957, EBI-355153; Q13415:ORC1; NbExp=6; IntAct=EBI-374957, EBI-374847; O43929:ORC4; NbExp=6; IntAct=EBI-374957, EBI-374889; O43913:ORC5; NbExp=7; IntAct=EBI-374957, EBI-374928; SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the ORC2 family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/orc2l/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13416
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003688 DNA replication origin binding GO:0005515 protein binding
Biological Process: GO:0000082 G1/S transition of mitotic cell cycle GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006260 DNA replication GO:0006270 DNA replication initiation
JD071923 - Sequence 52947 from Patent EP1572962. U27459 - Human origin recognition complex protein 2 homolog hORC2L mRNA, complete cds. BC014834 - Homo sapiens origin recognition complex, subunit 2-like (yeast), mRNA (cDNA clone MGC:5159 IMAGE:2899929), complete cds. U40268 - Homo sapiens origin recognition complex 2 homolog (Orc2) mRNA, complete cds. JD386385 - Sequence 367409 from Patent EP1572962. JD494252 - Sequence 475276 from Patent EP1572962. JD203241 - Sequence 184265 from Patent EP1572962. JD081023 - Sequence 62047 from Patent EP1572962. JD362855 - Sequence 343879 from Patent EP1572962. JD202111 - Sequence 183135 from Patent EP1572962. DQ894783 - Synthetic construct Homo sapiens clone IMAGE:100009243; FLH178395.01L; RZPDo839C09127D origin recognition complex, subunit 2-like (yeast) (ORC2L) gene, encodes complete protein. AB528396 - Synthetic construct DNA, clone: pF1KB6103, Homo sapiens ORC2L gene for origin recognition complex, subunit 2-like, without stop codon, in Flexi system. AK316433 - Homo sapiens cDNA, FLJ79332 complete cds, highly similar to Origin recognition complex subunit 2. AK302614 - Homo sapiens cDNA FLJ60060 complete cds, highly similar to Origin recognition complex subunit 2. JD305982 - Sequence 287006 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_mcmPathway - CDK Regulation of DNA Replication
Reactome (by CSHL, EBI, and GO)
Protein Q13416 (Reactome details) participates in the following event(s):
R-HSA-68595 Orc3 associates with Orc2 constitutively bound at origins of replication R-HSA-176973 Association of MCM8 with ORC:origin complex R-HSA-68615 Orc6 associates with Orc1:Orc4:Orc5:Orc3:Orc2:origin complexes, forming ORC:origin complexes R-HSA-68603 Orc5 associates with Orc3:Orc2:origin complexes R-HSA-68688 CDC6 association with ORC:origin complexes mediated by MCM8 R-HSA-113638 Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation R-HSA-68944 Orc1 is phosphorylated by cyclin A/CDK2 R-HSA-68610 Orc4 associates with Orc5:Orc3:Orc2:origin complexes R-HSA-68826 Free CDT1 associates with CDC6:ORC:origin complexes R-HSA-68611 Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes R-HSA-68849 Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC) R-HSA-68919 Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 R-HSA-68918 CDK and DDK associate with the Mcm10:pre-replicative complex R-HSA-68940 Cdt1 is displaced from the pre-replicative complex. R-HSA-68917 Cdc45 associates with the pre-replicative complex at the origin R-HSA-68916 DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin R-HSA-176318 Loading of claspin onto DNA during replication origin firing R-HSA-176298 Activation of claspin R-HSA-68616 Assembly of the ORC complex at the origin of replication R-HSA-68867 Assembly of the pre-replicative complex R-HSA-69002 DNA Replication Pre-Initiation R-HSA-68689 CDC6 association with the ORC:origin complex R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation R-HSA-68949 Orc1 removal from chromatin R-HSA-68874 M/G1 Transition R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex R-HSA-113510 E2F mediated regulation of DNA replication R-HSA-69052 Switching of origins to a post-replicative state R-HSA-69278 Cell Cycle (Mitotic) R-HSA-69306 DNA Replication R-HSA-69206 G1/S Transition R-HSA-69239 Synthesis of DNA R-HSA-1640170 Cell Cycle R-HSA-68962 Activation of the pre-replicative complex R-HSA-453279 Mitotic G1-G1/S phases R-HSA-69242 S Phase R-HSA-176187 Activation of ATR in response to replication stress R-HSA-69481 G2/M Checkpoints R-HSA-69620 Cell Cycle Checkpoints
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
