ID:OSBL1_HUMAN DESCRIPTION: RecName: Full=Oxysterol-binding protein-related protein 1; Short=ORP-1; Short=OSBP-related protein 1; FUNCTION: Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. SUBUNIT: Interacts with VAPA (By similarity). Interacts with the GTP-bound form of RAB7A. Interacts with OAS1B (By similarity). SUBCELLULAR LOCATION: Late endosome. Note=Co-localizes with RAB7A, RAB9A and LAMP1 in late endosomes. SIMILARITY: Belongs to the OSBP family. SIMILARITY: Contains 3 ANK repeats. SIMILARITY: Contains 1 PH domain. SEQUENCE CAUTION: Sequence=AAG53407.2; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BXW6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006699 bile acid biosynthetic process GO:0006869 lipid transport GO:0008203 cholesterol metabolic process GO:0015918 sterol transport GO:0016192 vesicle-mediated transport GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
