ID:OSMR_HUMAN DESCRIPTION: RecName: Full=Oncostatin-M-specific receptor subunit beta; AltName: Full=Interleukin-31 receptor subunit beta; Short=IL-31 receptor subunit beta; Short=IL-31R subunit beta; Short=IL-31R-beta; Short=IL-31RB; Flags: Precursor; FUNCTION: Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. SUBUNIT: Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). TISSUE SPECIFICITY: Expressed at relatively high levels in all neural cells as well as fibroblast, epithelial and a variety of tumor cell lines. INDUCTION: Activated by oncostatin-M. Up-regulated by IFNG/IFN- gamma and bacterial lipopolysaccharides (LPS). DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding (By similarity). DOMAIN: The box 1 motif is required for JAK interaction and/or activation (By similarity). DISEASE: Defects in OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1) [MIM:105250]; also known as familial lichen amyloidosis or familial cutaneous lichen amyloidosis. PLCA1 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. SIMILARITY: Belongs to the type I cytokine receptor family. Type 2 subfamily. SIMILARITY: Contains 4 fibronectin type-III domains. SEQUENCE CAUTION: Sequence=AAH63468.1; Type=Erroneous termination; Positions=216; Note=Translated as Glu; Sequence=AAH63468.1; Type=Frameshift; Positions=232, 288;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00041 - Fibronectin type III domain PF17971 - Leukemia inhibitory factor receptor D2 domain
SCOP Domains: 48726 - Immunoglobulin 49265 - Fibronectin type III
ModBase Predicted Comparative 3D Structure on Q99650
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
