Human Gene OTUD4 (ENST00000447906.8_9) from GENCODE V47lift37
  Description: OTU deubiquitinase 4, transcript variant 4 (from RefSeq NM_001366057.1)
Gencode Transcript: ENST00000447906.8_9
Gencode Gene: ENSG00000164164.17_15
Transcript (Including UTRs)
   Position: hg19 chr4:146,054,802-146,101,741 Size: 46,940 Total Exon Count: 21 Strand: -
Coding Region
   Position: hg19 chr4:146,058,582-146,101,125 Size: 42,544 Coding Exon Count: 21 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:146,054,802-146,101,741)mRNA (may differ from genome)Protein (1114 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: OTUD4_HUMAN
DESCRIPTION: RecName: Full=OTU domain-containing protein 4; AltName: Full=HIV-1-induced protein HIN-1;
INDUCTION: By HIV-1 insertion.
SIMILARITY: Contains 1 OTU domain.
SEQUENCE CAUTION: Sequence=AAI18573.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI18654.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=ABD72605.1; Type=Erroneous gene model prediction; Sequence=BAA82998.2; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=BAB71229.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA48313.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Originates from a chimeric transcript in HIV-1-infected cells. The premature stop may be due to intron retention;
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/otud4/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: OTUD4
Diseases sorted by gene-association score: hypogonadotropism (10), hiv-1 (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.01 RPKM in Testis
Total median expression: 364.20 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -321.40616-0.522 Picture PostScript Text
3' UTR -898.203780-0.238 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003323 - OTU

Pfam Domains:
PF02338 - OTU-like cysteine protease

SCOP Domains:
63748 - Tudor/PWWP/MBT
54001 - Cysteine proteinases

ModBase Predicted Comparative 3D Structure on Q01804
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0004843 thiol-dependent ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0032947 protein complex scaffold
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity
GO:0061578 Lys63-specific deubiquitinase activity

Biological Process:
GO:0002376 immune system process
GO:0006508 proteolysis
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0045087 innate immune response
GO:0070536 protein K63-linked deubiquitination
GO:0071108 protein K48-linked deubiquitination
GO:1901537 positive regulation of DNA demethylation
GO:1903093 regulation of protein K48-linked deubiquitination
GO:2000660 negative regulation of interleukin-1-mediated signaling pathway

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AB028969 - Homo sapiens mRNA for KIAA1046 protein, partial cds.
JD286255 - Sequence 267279 from Patent EP1572962.
JD531019 - Sequence 512043 from Patent EP1572962.
JD103289 - Sequence 84313 from Patent EP1572962.
JD250706 - Sequence 231730 from Patent EP1572962.
JD228866 - Sequence 209890 from Patent EP1572962.
JD389683 - Sequence 370707 from Patent EP1572962.
JD110771 - Sequence 91795 from Patent EP1572962.
JD524476 - Sequence 505500 from Patent EP1572962.
JD248889 - Sequence 229913 from Patent EP1572962.
JD273520 - Sequence 254544 from Patent EP1572962.
JD090724 - Sequence 71748 from Patent EP1572962.
JD222906 - Sequence 203930 from Patent EP1572962.
JD490671 - Sequence 471695 from Patent EP1572962.
JD510682 - Sequence 491706 from Patent EP1572962.
JD041811 - Sequence 22835 from Patent EP1572962.
JD086771 - Sequence 67795 from Patent EP1572962.
JD486602 - Sequence 467626 from Patent EP1572962.
JD268487 - Sequence 249511 from Patent EP1572962.
JD295810 - Sequence 276834 from Patent EP1572962.
JD269763 - Sequence 250787 from Patent EP1572962.
JD105021 - Sequence 86045 from Patent EP1572962.
JD120479 - Sequence 101503 from Patent EP1572962.
JD316361 - Sequence 297385 from Patent EP1572962.
BC057242 - Homo sapiens OTU domain containing 4, mRNA (cDNA clone IMAGE:4276528), partial cds.
JD312881 - Sequence 293905 from Patent EP1572962.
AK302581 - Homo sapiens cDNA FLJ56410 complete cds, highly similar to Homo sapiens OTU domain containing 4 (OTUD4), transcript variant 1, mRNA.
BC118572 - Homo sapiens OTU domain containing 4, mRNA (cDNA clone MGC:126484 IMAGE:40036249), complete cds.
BC118653 - Homo sapiens OTU domain containing 4, mRNA (cDNA clone MGC:126483 IMAGE:40036248), complete cds.
JD104507 - Sequence 85531 from Patent EP1572962.
AL137460 - Homo sapiens mRNA; cDNA DKFZp434I0721 (from clone DKFZp434I0721).
AK056597 - Homo sapiens cDNA FLJ32035 fis, clone NTONG2000363.
BC020682 - Homo sapiens OTU domain containing 4, mRNA (cDNA clone IMAGE:4804803), partial cds.
X68242 - H.sapiens mRNA for Hin-1.
JD112940 - Sequence 93964 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DYS4, ENST00000447906.1, ENST00000447906.2, ENST00000447906.3, ENST00000447906.4, ENST00000447906.5, ENST00000447906.6, ENST00000447906.7, HIN-1 , KIAA1046 , NM_001366057, OTUD4 , OTUD4_HUMAN, Q01804, Q147U2, Q1ZYK1, Q6PG39, Q96MQ5, Q9NT94, Q9UPV6, uc320pnh.1, uc320pnh.2
UCSC ID: ENST00000447906.8_9
RefSeq Accession: NM_001366057.1
Protein: Q01804 (aka OTUD4_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.