Human Gene OXER1 (ENST00000378661.4_8) from GENCODE V47lift37
  Description: oxoeicosanoid receptor 1 (from RefSeq NM_148962.5)
Gencode Transcript: ENST00000378661.4_8
Gencode Gene: ENSG00000162881.7_9
Transcript (Including UTRs)
   Position: hg19 chr2:42,989,639-42,991,275 Size: 1,637 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr2:42,990,048-42,991,202 Size: 1,155 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:42,989,639-42,991,275)mRNA (may differ from genome)Protein (384 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: OXER1_HUMAN
DESCRIPTION: RecName: Full=Oxoeicosanoid receptor 1; AltName: Full=5-oxo-ETE G-protein coupled receptor; AltName: Full=G-protein coupled receptor 170; AltName: Full=G-protein coupled receptor R527; AltName: Full=G-protein coupled receptor TG1019;
FUNCTION: Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in various tissues except brain. Expression is more intense in liver, kidney, peripheral leukocyte, lung, and spleen than in other tissues. Highly expressed in eosinophils, neutrophils, and lung macrophages.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
SEQUENCE CAUTION: Sequence=AAO17739.1; Type=Erroneous initiation; Sequence=BAC05878.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.33 RPKM in Liver
Total median expression: 116.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -19.2073-0.263 Picture PostScript Text
3' UTR -159.20409-0.389 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q8TDS5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0050646 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding
GO:0050647 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding
GO:0050648 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC063549 - Homo sapiens oxoeicosanoid (OXE) receptor 1, mRNA (cDNA clone MGC:75428 IMAGE:4777971), complete cds.
AB083055 - Homo sapiens tg1019 mRNA for G-protein coupled receptor, complete cds.
JD045420 - Sequence 26444 from Patent EP1572962.
AY158687 - Homo sapiens putative 5-oxo-ETE G-protein coupled receptor mRNA, complete cds.
KJ895739 - Synthetic construct Homo sapiens clone ccsbBroadEn_05133 OXER1 gene, encodes complete protein.
AB528920 - Synthetic construct DNA, clone: pF1KE0711, Homo sapiens OXER1 gene for oxoeicosanoid (OXE) receptor 1, without stop codon, in Flexi system.
JD140728 - Sequence 121752 from Patent EP1572962.
JD392687 - Sequence 373711 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8TDS5 (Reactome details) participates in the following event(s):

R-HSA-391905 Oxoeicosanoid receptor can bind oxoeicosanoid
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-391903 Eicosanoid ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000378661.1, ENST00000378661.2, ENST00000378661.3, GPR170, NM_148962, OXER1_HUMAN, Q86WP7, Q8NGW4, Q8TDS5, TG1019, uc318ole.1, uc318ole.2
UCSC ID: ENST00000378661.4_8
RefSeq Accession: NM_148962.5
Protein: Q8TDS5 (aka OXER1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.