ID:P2RX7_HUMAN DESCRIPTION: RecName: Full=P2X purinoceptor 7; Short=P2X7; AltName: Full=ATP receptor; AltName: Full=P2Z receptor; AltName: Full=Purinergic receptor; FUNCTION: Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. SUBUNIT: Functional P2XRs are organized as homomeric and heteromeric trimers. Interacts with LAMA3, ITGB2, ACTB, ACTN4, SVIL, MPP3, HSPA1, HSPCB, HSPA8, PIK230 and PTPRB. INTERACTION: P00519:ABL1; NbExp=1; IntAct=EBI-1753251, EBI-375543; P62993:GRB2; NbExp=1; IntAct=EBI-1753251, EBI-401755; P16333:NCK1; NbExp=1; IntAct=EBI-1753251, EBI-389883; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. PTM: Phosphorylation results in its inactivation. PTM: ADP-ribosylation at Arg-125 is necessary and sufficient to activate P2RX7 and gate the channel (By similarity). PTM: Palmitoylation of several cysteines in the C-terminal cytoplasmic tail is required for efficient localization to cell surface. SIMILARITY: Belongs to the P2X receptor family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org//Genes/P2RX7ID41623ch12q24.html"; WEB RESOURCE: Name=Wikipedia; Note=P2X receptor entry; URL="http://en.wikipedia.org/wiki/P2X_receptor"; WEB RESOURCE: Name=Wikipedia; Note=P2RX7 entry; URL="http://en.wikipedia.org/wiki/P2RX7";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99572
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000187 activation of MAPK activity GO:0000902 cell morphogenesis GO:0001845 phagolysosome assembly GO:0001916 positive regulation of T cell mediated cytotoxicity GO:0001934 positive regulation of protein phosphorylation GO:0002028 regulation of sodium ion transport GO:0006468 protein phosphorylation GO:0006509 membrane protein ectodomain proteolysis GO:0006649 phospholipid transfer to membrane GO:0006811 ion transport GO:0006812 cation transport GO:0006816 calcium ion transport GO:0006884 cell volume homeostasis GO:0006900 membrane budding GO:0006954 inflammatory response GO:0007005 mitochondrion organization GO:0007009 plasma membrane organization GO:0007166 cell surface receptor signaling pathway GO:0007596 blood coagulation GO:0009612 response to mechanical stimulus GO:0009617 response to bacterium GO:0010033 response to organic substance GO:0010043 response to zinc ion GO:0010467 gene expression GO:0010524 positive regulation of calcium ion transport into cytosol GO:0010628 positive regulation of gene expression GO:0012501 programmed cell death GO:0014049 positive regulation of glutamate secretion GO:0014054 positive regulation of gamma-aminobutyric acid secretion GO:0014070 response to organic cyclic compound GO:0016079 synaptic vesicle exocytosis GO:0016485 protein processing GO:0017121 phospholipid scrambling GO:0019233 sensory perception of pain GO:0019835 cytolysis GO:0030163 protein catabolic process GO:0030501 positive regulation of bone mineralization GO:0031668 cellular response to extracellular stimulus GO:0032060 bleb assembly GO:0032308 positive regulation of prostaglandin secretion GO:0032496 response to lipopolysaccharide GO:0032731 positive regulation of interleukin-1 beta production GO:0032755 positive regulation of interleukin-6 production GO:0032963 collagen metabolic process GO:0033198 response to ATP GO:0034405 response to fluid shear stress GO:0034767 positive regulation of ion transmembrane transport GO:0035590 purinergic nucleotide receptor signaling pathway GO:0042098 T cell proliferation GO:0042493 response to drug GO:0043029 T cell homeostasis GO:0043065 positive regulation of apoptotic process GO:0043085 positive regulation of catalytic activity GO:0043132 NAD transport GO:0043409 negative regulation of MAPK cascade GO:0043410 positive regulation of MAPK cascade GO:0045332 phospholipid translocation GO:0045778 positive regulation of ossification GO:0045779 negative regulation of bone resorption GO:0045794 negative regulation of cell volume GO:0045821 positive regulation of glycolytic process GO:0045919 positive regulation of cytolysis GO:0046513 ceramide biosynthetic process GO:0046931 pore complex assembly GO:0048705 skeletal system morphogenesis GO:0048873 homeostasis of number of cells within a tissue GO:0050714 positive regulation of protein secretion GO:0050715 positive regulation of cytokine secretion GO:0050717 positive regulation of interleukin-1 alpha secretion GO:0050718 positive regulation of interleukin-1 beta secretion GO:0050830 defense response to Gram-positive bacterium GO:0051209 release of sequestered calcium ion into cytosol GO:0051259 protein oligomerization GO:0051495 positive regulation of cytoskeleton organization GO:0051592 response to calcium ion GO:0051602 response to electrical stimulus GO:0051709 regulation of killing of cells of other organism GO:0051899 membrane depolarization GO:0051901 positive regulation of mitochondrial depolarization GO:0060079 excitatory postsynaptic potential GO:0070230 positive regulation of lymphocyte apoptotic process GO:0071359 cellular response to dsRNA GO:0071407 cellular response to organic cyclic compound GO:0072593 reactive oxygen species metabolic process GO:0097190 apoptotic signaling pathway GO:0097191 extrinsic apoptotic signaling pathway GO:0098655 cation transmembrane transport GO:1904172 positive regulation of bleb assembly
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
