Human Gene P2RY1 (ENST00000305097.6_4) from GENCODE V47lift37

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Description: purinergic receptor P2Y1 (from RefSeq NM_002563.5)
Gencode Transcript: ENST00000305097.6_4
Gencode Gene: ENSG00000169860.7_7
Transcript (Including UTRs)
Position: hg19 chr3:152,552,920-152,559,228 Size: 6,309 Total Exon Count: 1 Strand: +
Coding Region
Position: hg19 chr3:152,553,572-152,554,693 Size: 1,122 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr3:152,552,920-152,559,228)			mRNA (may differ from genome)		Protein (373 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: P2RY1_HUMAN DESCRIPTION: RecName: Full=P2Y purinoceptor 1; Short=P2Y1; AltName: Full=ATP receptor; AltName: Full=Purinergic receptor; FUNCTION: Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. INDUCTION: Repressed by the P2Y1 receptor-specific antagonists A3P5PS, A3P5P and A2P5P. These inhibit calcium ion mobilization and shape change in platelets. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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MalaCards Disease Associations


	MalaCards Gene Search: P2RY1 Diseases sorted by gene-association score: clopidogrel resistance (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C111914 N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate D000255 Adenosine Triphosphate D020001 1-Butanol D002118 Calcium C070515 bisindolylmaleimide I C070379 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester C023514 2,6-dinitrotoluene C113043 2-methylthio-ADP C008501 2-methylthio-ATP C028451 3,4,3',4'-tetrachlorobiphenyl C412373 AG 1879 D000082 Acetaminophen D000244 Adenosine Diphosphate D000643 Ammonium Chloride D001241 Aspirin D001564 Benzo(a)pyrene D002251 Carbon Tetrachloride D003993 Dibutyl Phthalate D004041 Dietary Fats D019833 Genistein D006861 Hydrogen Peroxide D008731 Methoxychlor D009711 Nucleotides D010269 Paraquat D037342 Pertussis Toxin D010622 Phencyclidine D011285 Pregnenolone Carbonitrile D013749 Tetrachlorodibenzodioxin D014241 Trichloroethylene C038699 acetophenone C467001 bisindolylmaleimide IX C008261 lead acetate C025256 nonylphenol C006253 pirinixic acid C077792 pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid C085746 rottlerin C447031 tyrphostin AG 1024

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 6.97 RPKM in Esophagus - Mucosa Total median expression: 63.90 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-316.70	652	-0.486	Picture	PostScript	Text
3' UTR	-1080.70	4535	-0.238	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR002286 - P2_purnocptor
IPR000142 - P2Y_purnocptor

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1Y36 - Model

ModBase Predicted Comparative 3D Structure on P47900


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0004871 signal transducer activity GO:0004930 G-protein coupled receptor activity GO:0005515 protein binding GO:0005524 ATP binding GO:0031686 A1 adenosine receptor binding GO:0038023 signaling receptor activity GO:0043531 ADP binding GO:0045028 G-protein coupled purinergic nucleotide receptor activity GO:0045031 ATP-activated adenosine receptor activity GO:0045032 ADP-activated adenosine receptor activity GO:0046982 protein heterodimerization activity GO:0097110 scaffold protein binding Biological Process: GO:0001934 positive regulation of protein phosphorylation GO:0001973 adenosine receptor signaling pathway GO:0007165 signal transduction GO:0007166 cell surface receptor signaling pathway GO:0007186 G-protein coupled receptor signaling pathway GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007568 aging GO:0007596 blood coagulation GO:0007599 hemostasis GO:0008347 glial cell migration GO:0009612 response to mechanical stimulus GO:0010469 regulation of receptor activity GO:0010700 negative regulation of norepinephrine secretion GO:0019233 sensory perception of pain GO:0023019 signal transduction involved in regulation of gene expression GO:0030168 platelet activation GO:0032962 positive regulation of inositol trisphosphate biosynthetic process GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway GO:0042060 wound healing GO:0042755 eating behavior GO:0043270 positive regulation of ion transport GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046887 positive regulation of hormone secretion GO:0051100 negative regulation of binding GO:0060406 positive regulation of penile erection GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070848 response to growth factor GO:0071407 cellular response to organic cyclic compound GO:0072659 protein localization to plasma membrane GO:0090075 relaxation of muscle GO:0097746 regulation of blood vessel diameter Cellular Component: GO:0005739 mitochondrion GO:0005886 plasma membrane GO:0005887 integral component of plasma membrane GO:0009986 cell surface GO:0014069 postsynaptic density GO:0016020 membrane GO:0016021 integral component of membrane GO:0016323 basolateral plasma membrane GO:0016324 apical plasma membrane GO:0030425 dendrite GO:0044297 cell body GO:0045211 postsynaptic membrane

Descriptions from all associated GenBank mRNAs


	LF206134 - JP 2014500723-A/13637: Polycomb-Associated Non-Coding RNAs. LF211892 - JP 2014500723-A/19395: Polycomb-Associated Non-Coding RNAs. Z49205 - H.sapiens mRNA for purinergic receptor. LP896278 - Sequence 1142 from Patent EP3253886. JD503649 - Sequence 484673 from Patent EP1572962. JD417115 - Sequence 398139 from Patent EP1572962. JD394591 - Sequence 375615 from Patent EP1572962. LF351745 - JP 2014500723-A/159248: Polycomb-Associated Non-Coding RNAs. JD416984 - Sequence 398008 from Patent EP1572962. JD463589 - Sequence 444613 from Patent EP1572962. JD147735 - Sequence 128759 from Patent EP1572962. JD421264 - Sequence 402288 from Patent EP1572962. JD410766 - Sequence 391790 from Patent EP1572962. AK313920 - Homo sapiens cDNA, FLJ94559, highly similar to Homo sapiens purinergic receptor P2Y, G-protein coupled, 1 (P2RY1), mRNA. U42030 - Human P2Y1 purinoceptor mRNA, long form, complete cds. U42029 - Human P2Y1 purinoceptor mRNA, short form, complete cds. BC074784 - Homo sapiens purinergic receptor P2Y, G-protein coupled, 1, mRNA (cDNA clone MGC:103950 IMAGE:30915343), complete cds. BC074785 - Homo sapiens purinergic receptor P2Y, G-protein coupled, 1, mRNA (cDNA clone MGC:104108 IMAGE:30915561), complete cds. AB464676 - Synthetic construct DNA, clone: pF1KB9845, Homo sapiens P2RY1 gene for purinergic receptor P2Y, G-protein coupled, 1, without stop codon, in Flexi system. KJ891741 - Synthetic construct Homo sapiens clone ccsbBroadEn_01135 P2RY1 gene, encodes complete protein. AY136752 - Homo sapiens purinergic receptor P2RY1 (P2RY1) mRNA, complete cds. AF018284 - Homo sapiens P2Y1 receptor (P2YR1) mRNA, partial cds. JD301360 - Sequence 282384 from Patent EP1572962. JD294827 - Sequence 275851 from Patent EP1572962. JD214128 - Sequence 195152 from Patent EP1572962. JD202423 - Sequence 183447 from Patent EP1572962. JD146749 - Sequence 127773 from Patent EP1572962. JD304105 - Sequence 285129 from Patent EP1572962. JD093441 - Sequence 74465 from Patent EP1572962. JD431624 - Sequence 412648 from Patent EP1572962. JD102240 - Sequence 83264 from Patent EP1572962. AK026659 - Homo sapiens cDNA: FLJ23006 fis, clone LNG00414. MA587322 - JP 2018138019-A/159248: Polycomb-Associated Non-Coding RNAs. MA441711 - JP 2018138019-A/13637: Polycomb-Associated Non-Coding RNAs. MA447469 - JP 2018138019-A/19395: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein P47900 (Reactome details) participates in the following event(s): R-HSA-417908 P2RY1 binds ADP R-HSA-418576 Dissociation of the P2Y purinoceptor 1:Gq complex R-HSA-418581 Activated P2Y purinoceptor 1 binds G-protein Gq R-NUL-428715 Activated human P2Y purinoceptor 1 binds mouse G-protein Gq R-HSA-749452 The Ligand:GPCR:Gq complex dissociates R-HSA-418579 Gq activation by P2Y purinoceptor 1 R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 R-HSA-417957 P2Y receptors R-HSA-418592 ADP signalling through P2Y purinoceptor 1 R-HSA-416476 G alpha (q) signalling events R-HSA-418038 Nucleotide-like (purinergic) receptors R-HSA-392518 Signal amplification R-HSA-388396 GPCR downstream signalling R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-372790 Signaling by GPCR R-HSA-500792 GPCR ligand binding R-HSA-109582 Hemostasis R-HSA-162582 Signal Transduction

Other Names for This Gene


	Alternate Gene Symbols: ENST00000305097.1, ENST00000305097.2, ENST00000305097.3, ENST00000305097.4, ENST00000305097.5, NM_002563, P2RY1_HUMAN, P47900, uc317nol.1, uc317nol.2 UCSC ID: ENST00000305097.6_4 RefSeq Accession: NM_002563.5 Protein: P47900 (aka P2RY1_HUMAN or P2YR_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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