Human Gene PAFAH1B2 (ENST00000527958.6_4) from GENCODE V47lift37

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Description: platelet activating factor acetylhydrolase 1b catalytic subunit 2, transcript variant 1 (from RefSeq NM_002572.4)
Gencode Transcript: ENST00000527958.6_4
Gencode Gene: ENSG00000168092.14_7
Transcript (Including UTRs)
Position: hg19 chr11:117,015,003-117,041,761 Size: 26,759 Total Exon Count: 6 Strand: +
Coding Region
Position: hg19 chr11:117,023,164-117,038,415 Size: 15,252 Coding Exon Count: 5

Page Index	Sequence and Links	Primers	CTD	Gene Alleles	RNA-Seq Expression
Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Other Names	Model Information
Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr11:117,015,003-117,041,761)			mRNA (may differ from genome)		Protein (229 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin D014635 Valproic Acid C029790 2,2',3',4,4',5-hexachlorobiphenyl C023514 2,6-dinitrotoluene D000082 Acetaminophen D016604 Aflatoxin B1 D000643 Ammonium Chloride D019256 Cadmium Chloride D002945 Cisplatin D019327 Copper Sulfate more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 23.44 RPKM in Brain - Cerebellar Hemisphere Total median expression: 601.31 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-60.90	139	-0.438	Picture	PostScript	Text
3' UTR	-881.70	3346	-0.264	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details		Gene Details
Gene Sorter	Gene Sorter		Gene Sorter
	RGD	Ensembl

Descriptions from all associated GenBank mRNAs


	BC039721 - Homo sapiens platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa, mRNA (cDNA clone IMAGE:6021409), with apparent retained intron. DQ836738 - Homo sapiens intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 5 (PAFAH1B2) mRNA, complete cds, alternatively spliced. DQ836739 - Homo sapiens intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 4 (PAFAH1B2) mRNA, complete cds, alternatively spliced. DQ836740 - Homo sapiens intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 3 (PAFAH1B2) mRNA, complete cds, alternatively spliced. AK292973 - Homo sapiens cDNA FLJ75836 complete cds, highly similar to Homo sapiens platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa (PAFAH1B2), mRNA. AK307366 - Homo sapiens cDNA, FLJ97314. BC000398 - Homo sapiens platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa, mRNA (cDNA clone MGC:8519 IMAGE:2822463), complete cds. BC019301 - Homo sapiens platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa, mRNA (cDNA clone MGC:4196 IMAGE:2822463), complete cds. FJ224328 - Homo sapiens epididymis secretory protein Li 303 (HEL-S-303) mRNA, complete cds. GQ891510 - Homo sapiens clone HEL-S-231 epididymis secretory sperm binding protein mRNA, complete cds. D63390 - Homo sapiens mRNA for acetylhydrolase IB beta-subunit, complete cds. BC001774 - Homo sapiens platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa, mRNA (cDNA clone IMAGE:3355383), partial cds. DQ836743 - Homo sapiens intracellular platelet-activating factor acetylhydrolase alpha 2 subunit (PAFAH1B2) mRNA, complete cds, alternatively spliced. DQ836742 - Homo sapiens intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 1 (PAFAH1B2) mRNA, complete cds, alternatively spliced. DQ836741 - Homo sapiens intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 2 (PAFAH1B2) mRNA, complete cds, alternatively spliced. CR456736 - Homo sapiens full open reading frame cDNA clone RZPDo834H036D for gene PAFAH1B2, platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa; complete cds, incl. stopcodon. AB527949 - Synthetic construct DNA, clone: pF1KB6940, Homo sapiens PAFAH1B2 gene for platelet-activating factor acetylhydrolase, isoform Ib, subunit 2, without stop codon, in Flexi system. KJ891748 - Synthetic construct Homo sapiens clone ccsbBroadEn_01142 PAFAH1B2 gene, encodes complete protein. JD434219 - Sequence 415243 from Patent EP1572962. JD348836 - Sequence 329860 from Patent EP1572962. JD564184 - Sequence 545208 from Patent EP1572962. JD550737 - Sequence 531761 from Patent EP1572962. JD410354 - Sequence 391378 from Patent EP1572962. BC021287 - Homo sapiens cDNA clone IMAGE:5019705, partial cds. BC010009 - Homo sapiens cDNA clone IMAGE:4310234, partial cds.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000527958.1, ENST00000527958.2, ENST00000527958.3, ENST00000527958.4, ENST00000527958.5, HEL-S-303 , NM_002572, uc324eag.1, uc324eag.2, V9HW44, V9HW44_HUMAN UCSC ID: ENST00000527958.6_4 RefSeq Accession: NM_002572.4

Gene Model Information


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Methods, Credits, and Use Restrictions


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