Human Gene PAIP2B (ENST00000244221.9_7) from GENCODE V47lift37
  Description: poly(A) binding protein interacting protein 2B (from RefSeq NM_020459.1)
Gencode Transcript: ENST00000244221.9_7
Gencode Gene: ENSG00000124374.9_9
Transcript (Including UTRs)
   Position: hg19 chr2:71,409,868-71,454,233 Size: 44,366 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr2:71,415,609-71,429,719 Size: 14,111 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:71,409,868-71,454,233)mRNA (may differ from genome)Protein (123 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PAI2B_HUMAN
DESCRIPTION: RecName: Full=Polyadenylate-binding protein-interacting protein 2B; Short=PABP-interacting protein 2B; Short=PAIP-2B; Short=Poly(A)-binding protein-interacting protein 2B;
SIMILARITY: Belongs to the PAIP2 family.
SEQUENCE CAUTION: Sequence=BAA86469.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 61.11 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 513.25 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -60.60187-0.324 Picture PostScript Text
3' UTR -1709.005741-0.298 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009818 - Ataxin-2_C

Pfam Domains:
PF07145 - Ataxin-2 C-terminal region

ModBase Predicted Comparative 3D Structure on Q9ULR5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000900 translation repressor activity, nucleic acid binding
GO:0005515 protein binding

Biological Process:
GO:0006417 regulation of translation
GO:0045947 negative regulation of translational initiation

Cellular Component:
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AB032981 - Homo sapiens KIAA1155 mRNA for KIAA1155 protein.
AL110211 - Homo sapiens mRNA; cDNA DKFZp564L2223 (from clone DKFZp564L2223).
JD355465 - Sequence 336489 from Patent EP1572962.
JD253487 - Sequence 234511 from Patent EP1572962.
JD068325 - Sequence 49349 from Patent EP1572962.
JD205497 - Sequence 186521 from Patent EP1572962.
JD369779 - Sequence 350803 from Patent EP1572962.
JD565456 - Sequence 546480 from Patent EP1572962.
JD423047 - Sequence 404071 from Patent EP1572962.
JD253244 - Sequence 234268 from Patent EP1572962.
JD095875 - Sequence 76899 from Patent EP1572962.
JD073269 - Sequence 54293 from Patent EP1572962.
JD294886 - Sequence 275910 from Patent EP1572962.
JD352227 - Sequence 333251 from Patent EP1572962.
JD166329 - Sequence 147353 from Patent EP1572962.
JD273608 - Sequence 254632 from Patent EP1572962.
JD285035 - Sequence 266059 from Patent EP1572962.
JD305056 - Sequence 286080 from Patent EP1572962.
JD375199 - Sequence 356223 from Patent EP1572962.
JD452738 - Sequence 433762 from Patent EP1572962.
JD287397 - Sequence 268421 from Patent EP1572962.
JD380172 - Sequence 361196 from Patent EP1572962.
JD263925 - Sequence 244949 from Patent EP1572962.
JD067745 - Sequence 48769 from Patent EP1572962.
JD521622 - Sequence 502646 from Patent EP1572962.
JD227384 - Sequence 208408 from Patent EP1572962.
JD290788 - Sequence 271812 from Patent EP1572962.
JD160089 - Sequence 141113 from Patent EP1572962.
JD440546 - Sequence 421570 from Patent EP1572962.
JD040662 - Sequence 21686 from Patent EP1572962.
JD552769 - Sequence 533793 from Patent EP1572962.
JD561535 - Sequence 542559 from Patent EP1572962.
JD550690 - Sequence 531714 from Patent EP1572962.
JD310661 - Sequence 291685 from Patent EP1572962.
JD172586 - Sequence 153610 from Patent EP1572962.
JD469744 - Sequence 450768 from Patent EP1572962.
JD071864 - Sequence 52888 from Patent EP1572962.
JD397777 - Sequence 378801 from Patent EP1572962.
JD070153 - Sequence 51177 from Patent EP1572962.
JD447561 - Sequence 428585 from Patent EP1572962.
JD110429 - Sequence 91453 from Patent EP1572962.
JD385635 - Sequence 366659 from Patent EP1572962.
JD320184 - Sequence 301208 from Patent EP1572962.
JD541327 - Sequence 522351 from Patent EP1572962.
JD119362 - Sequence 100386 from Patent EP1572962.
JD328807 - Sequence 309831 from Patent EP1572962.
JD566844 - Sequence 547868 from Patent EP1572962.
JD276866 - Sequence 257890 from Patent EP1572962.
JD208199 - Sequence 189223 from Patent EP1572962.
JD076114 - Sequence 57138 from Patent EP1572962.
JD183794 - Sequence 164818 from Patent EP1572962.
JD089198 - Sequence 70222 from Patent EP1572962.
JD323648 - Sequence 304672 from Patent EP1572962.
JD300221 - Sequence 281245 from Patent EP1572962.
JD323416 - Sequence 304440 from Patent EP1572962.
JD097063 - Sequence 78087 from Patent EP1572962.
JD553380 - Sequence 534404 from Patent EP1572962.
JD167791 - Sequence 148815 from Patent EP1572962.
JD204120 - Sequence 185144 from Patent EP1572962.
JD296539 - Sequence 277563 from Patent EP1572962.
JD164286 - Sequence 145310 from Patent EP1572962.
JD276920 - Sequence 257944 from Patent EP1572962.
JD543920 - Sequence 524944 from Patent EP1572962.
JD498002 - Sequence 479026 from Patent EP1572962.
JD298532 - Sequence 279556 from Patent EP1572962.
JD322328 - Sequence 303352 from Patent EP1572962.
JD083720 - Sequence 64744 from Patent EP1572962.
JD337860 - Sequence 318884 from Patent EP1572962.
JD044799 - Sequence 25823 from Patent EP1572962.
JD427860 - Sequence 408884 from Patent EP1572962.
JD195160 - Sequence 176184 from Patent EP1572962.
JD237114 - Sequence 218138 from Patent EP1572962.
JD291659 - Sequence 272683 from Patent EP1572962.
JD048834 - Sequence 29858 from Patent EP1572962.
JD278921 - Sequence 259945 from Patent EP1572962.
JD296164 - Sequence 277188 from Patent EP1572962.
JD440182 - Sequence 421206 from Patent EP1572962.
AB384125 - Synthetic construct DNA, clone: pF1KSDA1155, Homo sapiens PAIP2B gene for poly(A) binding protein interacting protein 2B, complete cds, without stop codon, in Flexi system.
BC156857 - Synthetic construct Homo sapiens clone IMAGE:100062590, MGC:190577 poly(A) binding protein interacting protein 2B (PAIP2B) mRNA, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000244221.1, ENST00000244221.2, ENST00000244221.3, ENST00000244221.4, ENST00000244221.5, ENST00000244221.6, ENST00000244221.7, ENST00000244221.8, KIAA1155, NM_020459, PAI2B_HUMAN, Q9ULR5, uc317eob.1, uc317eob.2
UCSC ID: ENST00000244221.9_7
RefSeq Accession: NM_020459.1
Protein: Q9ULR5 (aka PAI2B_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.