ID:PK1IP_HUMAN DESCRIPTION: RecName: Full=p21-activated protein kinase-interacting protein 1; AltName: Full=PAK/PLC-interacting protein 1; Short=hPIP1; AltName: Full=PAK1-interacting protein 1; AltName: Full=WD repeat-containing protein 84; FUNCTION: Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which have been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. SUBUNIT: Interacts with PAK1. SUBCELLULAR LOCATION: Nucleus, nucleolus. TISSUE SPECIFICITY: Expressed in brain, colon, heart, kidney, liver, lung, muscle, peripheral blood leukocytes, placenta, small intestine, spleen and thymus. SIMILARITY: Contains 5 WD repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NWT1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0008283 cell proliferation GO:0009968 negative regulation of signal transduction GO:0042254 ribosome biogenesis GO:0042273 ribosomal large subunit biogenesis GO:0060021 palate development GO:1901796 regulation of signal transduction by p53 class mediator
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
