Human Gene PARP12 (ENST00000263549.8_6) from GENCODE V47lift37
Description: poly(ADP-ribose) polymerase family member 12, transcript variant 1 (from RefSeq NM_022750.4)
Gencode Transcript: ENST00000263549.8_6
Gencode Gene: ENSG00000059378.13_10
Transcript (Including UTRs)
Position: hg19 chr7:139,723,549-139,762,751 Size: 39,203 Total Exon Count: 12 Strand: -
Coding Region
Position: hg19 chr7:139,724,360-139,762,647 Size: 38,288 Coding Exon Count: 12
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: PAR12_HUMAN
DESCRIPTION: RecName: Full=Poly [ADP-ribose] polymerase 12; Short=PARP-12; EC=2.4.2.30; AltName: Full=ADP-ribosyltransferase diphtheria toxin-like 12; Short=ARTD12; AltName: Full=Zinc finger CCCH domain-containing protein 1;
CATALYTIC ACTIVITY: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.SUBCELLULAR LOCATION: Nucleus (Probable).SIMILARITY: Contains 4 C3H1-type zinc fingers.SIMILARITY: Contains 1 PARP catalytic domain.SIMILARITY: Contains 2 WWE domains.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR012317 - Poly(ADP-ribose)pol_cat_dom
IPR004170 - WWE-dom
IPR000571 - Znf_CCCH
Pfam Domains: PF00642 - Zinc finger C-x8-C-x5-C-x3-H type (and similar)
PF00644 - Poly(ADP-ribose) polymerase catalytic domain
PF02825 - WWE domain
PF14608 - RNA-binding, Nab2-type zinc finger
SCOP Domains: 56399 - ADP-ribosylation
117839 - WWE domain
90229 - CCCH zinc finger
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on Q9H0J9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AF173884 - Homo sapiens MSTP109 (MST109) mRNA, complete cds.AK026346 - Homo sapiens cDNA: FLJ22693 fis, clone HSI11445.AL137255 - Homo sapiens mRNA; cDNA DKFZp434B1813 (from clone DKFZp434B1813); partial cds.BC044660 - Homo sapiens poly (ADP-ribose) polymerase family, member 12, mRNA (cDNA clone IMAGE:4428430), containing frame-shift errors.AL136766 - Homo sapiens mRNA; cDNA DKFZp434A0516 (from clone DKFZp434A0516); complete cds.BC081541 - Homo sapiens poly (ADP-ribose) polymerase family, member 12, mRNA (cDNA clone MGC:71625 IMAGE:5296560), complete cds.JD339152 - Sequence 320176 from Patent EP1572962.JD345754 - Sequence 326778 from Patent EP1572962.JD522623 - Sequence 503647 from Patent EP1572962.JD040251 - Sequence 21275 from Patent EP1572962.JD092945 - Sequence 73969 from Patent EP1572962.JD276509 - Sequence 257533 from Patent EP1572962.JD364019 - Sequence 345043 from Patent EP1572962.JD098718 - Sequence 79742 from Patent EP1572962.JD057861 - Sequence 38885 from Patent EP1572962.JD467898 - Sequence 448922 from Patent EP1572962.JD566421 - Sequence 547445 from Patent EP1572962.JD566426 - Sequence 547450 from Patent EP1572962.JD246530 - Sequence 227554 from Patent EP1572962.JD118995 - Sequence 100019 from Patent EP1572962.JD518495 - Sequence 499519 from Patent EP1572962.JD500172 - Sequence 481196 from Patent EP1572962.KJ899471 - Synthetic construct Homo sapiens clone ccsbBroadEn_08865 PARP12 gene, encodes complete protein.JD209716 - Sequence 190740 from Patent EP1572962.JD517074 - Sequence 498098 from Patent EP1572962.JD392874 - Sequence 373898 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: ENST00000263549.1, ENST00000263549.2, ENST00000263549.3, ENST00000263549.4, ENST00000263549.5, ENST00000263549.6, ENST00000263549.7, NM_022750, PAR12_HUMAN, PARP12 , Q9H0J9, Q9H610, Q9NP36, Q9NTI3, uc317hkh.1, uc317hkh.2, ZC3HDC1UCSC ID: ENST00000263549.8_6RefSeq Accession: NM_022750.4
Protein: Q9H0J9
(aka PAR12_HUMAN)
Gene Model Information
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.