Human Gene PARP14 (ENST00000474629.7_4) from GENCODE V47lift37
  Description: poly(ADP-ribose) polymerase family member 14 (from RefSeq NM_017554.3)
Gencode Transcript: ENST00000474629.7_4
Gencode Gene: ENSG00000173193.15_10
Transcript (Including UTRs)
   Position: hg19 chr3:122,399,686-122,449,687 Size: 50,002 Total Exon Count: 17 Strand: +
Coding Region
   Position: hg19 chr3:122,399,731-122,447,444 Size: 47,714 Coding Exon Count: 17 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:122,399,686-122,449,687)mRNA (may differ from genome)Protein (1801 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PAR14_HUMAN
DESCRIPTION: RecName: Full=Poly [ADP-ribose] polymerase 14; Short=PARP-14; EC=2.4.2.30; AltName: Full=ADP-ribosyltransferase diphtheria toxin-like 8; Short=ARTD8; AltName: Full=B aggressive lymphoma protein 2;
FUNCTION: Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity.
CATALYTIC ACTIVITY: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
SUBUNIT: Interacts with STAT6 (By similarity).
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=In steady state cells the protein is mostly nuclear. A minor proportion is detected in the cytoplasm (By similarity).
SIMILARITY: Contains 3 Macro domains.
SIMILARITY: Contains 1 PARP catalytic domain.
SIMILARITY: Contains 1 WWE domain.
SEQUENCE CAUTION: Sequence=AAY64449.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAY64450.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14089.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=DB237115; Type=Frameshift; Positions=48;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 44.78 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 385.01 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -13.8045-0.307 Picture PostScript Text
3' UTR -626.402243-0.279 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002589 - A1pp
IPR012317 - Poly(ADP-ribose)pol_cat_dom
IPR004170 - WWE-dom

Pfam Domains:
PF00644 - Poly(ADP-ribose) polymerase catalytic domain
PF01661 - Macro domain

SCOP Domains:
52949 - Macro domain-like
56399 - ADP-ribosylation
117839 - WWE domain
54791 - Eukaryotic type KH-domain (KH-domain type I)
54928 - RNA-binding domain, RBD

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3GOY - X-ray MuPIT 3Q6Z - X-ray MuPIT 3Q71 - X-ray MuPIT 3SE2 - X-ray MuPIT 3SMI - X-ray MuPIT 3SMJ - X-ray MuPIT 4F1L - X-ray MuPIT 4F1Q - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q460N5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0019899 enzyme binding
GO:0070403 NAD+ binding

Biological Process:
GO:0002376 immune system process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006471 protein ADP-ribosylation
GO:0010629 negative regulation of gene expression
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
GO:0045087 innate immune response
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
GO:0070212 protein poly-ADP-ribosylation
GO:1902216 positive regulation of interleukin-4-mediated signaling pathway

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  AK304269 - Homo sapiens cDNA FLJ58148 partial cds, highly similar to Poly (ADP-ribose) polymerase 14 (EC 2.4.2.30).
BC172392 - Synthetic construct Homo sapiens clone IMAGE:100069086, MGC:199097 poly (ADP-ribose) polymerase family, member 14 (PARP14) mRNA, encodes complete protein.
DQ063585 - Homo sapiens B-aggressive lymphoma 2A (BAL2A) mRNA, complete cds.
DQ063584 - Homo sapiens B-aggressive lymphoma 2B (BAL2B) mRNA, complete cds.
BX648758 - Homo sapiens mRNA; cDNA DKFZp686O21109 (from clone DKFZp686O21109).
FW340085 - Screening.
AY134858 - Homo sapiens unknown mRNA.
AK098816 - Homo sapiens cDNA FLJ25950 fis, clone SYN00129.
AB033094 - Homo sapiens mRNA for KIAA1268 protein, partial cds.
AK026003 - Homo sapiens cDNA: FLJ22350 fis, clone HRC06313.
AK001770 - Homo sapiens cDNA FLJ10908 fis, clone OVARC1000087, weakly similar to HISTONE MACRO-H2A.1.
AK022542 - Homo sapiens cDNA FLJ12480 fis, clone NT2RM1001066.
BC039604 - Homo sapiens poly (ADP-ribose) polymerase family, member 14, mRNA (cDNA clone IMAGE:3847010), with apparent retained intron.
BC032804 - Homo sapiens poly (ADP-ribose) polymerase family, member 14, mRNA (cDNA clone IMAGE:3858942), partial cds.
AK027260 - Homo sapiens cDNA: FLJ23607 fis, clone LNG16050.
AF026945 - Homo sapiens cig64 mRNA, partial sequence.
JD344916 - Sequence 325940 from Patent EP1572962.
JD269698 - Sequence 250722 from Patent EP1572962.
JD174163 - Sequence 155187 from Patent EP1572962.
JD556726 - Sequence 537750 from Patent EP1572962.
JD468322 - Sequence 449346 from Patent EP1572962.
JD214934 - Sequence 195958 from Patent EP1572962.
JD057978 - Sequence 39002 from Patent EP1572962.
JD427592 - Sequence 408616 from Patent EP1572962.
JD146303 - Sequence 127327 from Patent EP1572962.
JD469480 - Sequence 450504 from Patent EP1572962.
JD049376 - Sequence 30400 from Patent EP1572962.
JD448608 - Sequence 429632 from Patent EP1572962.
JD352544 - Sequence 333568 from Patent EP1572962.
JD524757 - Sequence 505781 from Patent EP1572962.
JD414546 - Sequence 395570 from Patent EP1572962.
JD514486 - Sequence 495510 from Patent EP1572962.
JD371339 - Sequence 352363 from Patent EP1572962.
JD337687 - Sequence 318711 from Patent EP1572962.
JD463227 - Sequence 444251 from Patent EP1572962.
JD367580 - Sequence 348604 from Patent EP1572962.
JD535343 - Sequence 516367 from Patent EP1572962.
JD072286 - Sequence 53310 from Patent EP1572962.
JD285502 - Sequence 266526 from Patent EP1572962.
JD060248 - Sequence 41272 from Patent EP1572962.
JD356630 - Sequence 337654 from Patent EP1572962.
JD506344 - Sequence 487368 from Patent EP1572962.
JD374392 - Sequence 355416 from Patent EP1572962.
JD143749 - Sequence 124773 from Patent EP1572962.
JD130288 - Sequence 111312 from Patent EP1572962.
JD358733 - Sequence 339757 from Patent EP1572962.
JD081105 - Sequence 62129 from Patent EP1572962.
JD200999 - Sequence 182023 from Patent EP1572962.
JD164277 - Sequence 145301 from Patent EP1572962.
JD556099 - Sequence 537123 from Patent EP1572962.
JD113843 - Sequence 94867 from Patent EP1572962.
JD541546 - Sequence 522570 from Patent EP1572962.
JD300137 - Sequence 281161 from Patent EP1572962.
JD419960 - Sequence 400984 from Patent EP1572962.
JD168688 - Sequence 149712 from Patent EP1572962.
JD180114 - Sequence 161138 from Patent EP1572962.
JD484554 - Sequence 465578 from Patent EP1572962.
JD330935 - Sequence 311959 from Patent EP1572962.
JD173075 - Sequence 154099 from Patent EP1572962.
JD237742 - Sequence 218766 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q460N5 (Reactome details) participates in the following event(s):

R-HSA-197264 Nicotinamide salvaging
R-HSA-196807 Nicotinate metabolism
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: B4E2H0, BAL2 , ENST00000474629.1, ENST00000474629.2, ENST00000474629.3, ENST00000474629.4, ENST00000474629.5, ENST00000474629.6, KIAA1268 , NM_017554, PAR14_HUMAN, PARP14 , Q460N4, Q460N5, Q8J027, Q9H9X9, Q9NV60, Q9ULF2, uc321sld.1, uc321sld.2
UCSC ID: ENST00000474629.7_4
RefSeq Accession: NM_017554.3
Protein: Q460N5 (aka PAR14_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.