Human Gene PARP6 (ENST00000569795.6_7) from GENCODE V47lift37
  Description: poly(ADP-ribose) polymerase family member 6, transcript variant 26 (from RefSeq NR_136611.2)
Gencode Transcript: ENST00000569795.6_7
Gencode Gene: ENSG00000137817.17_13
Transcript (Including UTRs)
   Position: hg19 chr15:72,533,522-72,564,895 Size: 31,374 Total Exon Count: 24 Strand: -
Coding Region
   Position: hg19 chr15:72,533,796-72,559,818 Size: 26,023 Coding Exon Count: 22 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:72,533,522-72,564,895)mRNA (may differ from genome)Protein (630 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PARP6_HUMAN
DESCRIPTION: RecName: Full=Poly [ADP-ribose] polymerase 6; Short=PARP-6; EC=2.4.2.30; AltName: Full=ADP-ribosyltransferase diphtheria toxin-like 17; Short=ARTD17;
CATALYTIC ACTIVITY: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
SIMILARITY: Contains 1 PARP catalytic domain.
SEQUENCE CAUTION: Sequence=BAB14969.1; Type=Erroneous initiation; Sequence=CAB59261.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 63.88 RPKM in Testis
Total median expression: 1281.73 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -216.60621-0.349 Picture PostScript Text
3' UTR -81.10274-0.296 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012317 - Poly(ADP-ribose)pol_cat_dom

Pfam Domains:
PF00644 - Poly(ADP-ribose) polymerase catalytic domain

SCOP Domains:
56399 - ADP-ribosylation

ModBase Predicted Comparative 3D Structure on Q2NL67
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups

Biological Process:
GO:0050775 positive regulation of dendrite morphogenesis


-  Descriptions from all associated GenBank mRNAs
  LF208528 - JP 2014500723-A/16031: Polycomb-Associated Non-Coding RNAs.
BC015176 - Homo sapiens poly (ADP-ribose) polymerase family, member 6, mRNA (cDNA clone IMAGE:3904612).
AL122091 - Homo sapiens mRNA; cDNA DKFZp566D244 (from clone DKFZp566D244).
BC110902 - Homo sapiens poly (ADP-ribose) polymerase family, member 6, mRNA (cDNA clone MGC:131971 IMAGE:6194444), complete cds.
AL390093 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1034327.
AK126416 - Homo sapiens cDNA FLJ44452 fis, clone UTERU2023175, highly similar to Homo sapiens poly (ADP-ribose) polymerase family, member 6 (PARP6), mRNA.
AK021790 - Homo sapiens cDNA FLJ11728 fis, clone HEMBA1005382.
AK024703 - Homo sapiens cDNA: FLJ21050 fis, clone CAS00422.
BC026955 - Homo sapiens poly (ADP-ribose) polymerase family, member 6, mRNA (cDNA clone IMAGE:5106605).
BC015314 - Homo sapiens poly (ADP-ribose) polymerase family, member 6, mRNA (cDNA clone IMAGE:3855831), partial cds.
AL390087 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1977056.
AK022547 - Homo sapiens cDNA FLJ12485 fis, clone NT2RM2000420.
AK091172 - Homo sapiens cDNA FLJ33853 fis, clone CTONG2005795.
AX746827 - Sequence 352 from Patent EP1308459.
JD103462 - Sequence 84486 from Patent EP1572962.
JD515480 - Sequence 496504 from Patent EP1572962.
KJ902925 - Synthetic construct Homo sapiens clone ccsbBroadEn_12319 PARP6 gene, encodes complete protein.
JD240758 - Sequence 221782 from Patent EP1572962.
LF377351 - JP 2014500723-A/184854: Polycomb-Associated Non-Coding RNAs.
JD313442 - Sequence 294466 from Patent EP1572962.
BC119688 - Homo sapiens poly (ADP-ribose) polymerase family, member 6, mRNA (cDNA clone IMAGE:40116673), partial cds.
BC119689 - Homo sapiens poly (ADP-ribose) polymerase family, member 6, mRNA (cDNA clone IMAGE:40116674), partial cds.
AB499727 - Homo sapiens PARP-6 mRNA for PARP-6-B1, complete cds.
KJ904829 - Synthetic construct Homo sapiens clone ccsbBroadEn_14223 PARP6 gene, encodes complete protein.
JD053437 - Sequence 34461 from Patent EP1572962.
JD356056 - Sequence 337080 from Patent EP1572962.
AB499728 - Homo sapiens PARP-6 mRNA for PARP-6-C, complete cds.
JD450827 - Sequence 431851 from Patent EP1572962.
JD346926 - Sequence 327950 from Patent EP1572962.
JD159229 - Sequence 140253 from Patent EP1572962.
JD206857 - Sequence 187881 from Patent EP1572962.
JD501256 - Sequence 482280 from Patent EP1572962.
JD254032 - Sequence 235056 from Patent EP1572962.
JD040431 - Sequence 21455 from Patent EP1572962.
JD062012 - Sequence 43036 from Patent EP1572962.
JD229577 - Sequence 210601 from Patent EP1572962.
AK308073 - Homo sapiens cDNA, FLJ98021.
JD256382 - Sequence 237406 from Patent EP1572962.
JD157036 - Sequence 138060 from Patent EP1572962.
JD134941 - Sequence 115965 from Patent EP1572962.
JD116087 - Sequence 97111 from Patent EP1572962.
MA444105 - JP 2018138019-A/16031: Polycomb-Associated Non-Coding RNAs.
MA612928 - JP 2018138019-A/184854: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q2NL67 (Reactome details) participates in the following event(s):

R-HSA-197264 Nicotinamide salvaging
R-HSA-196807 Nicotinate metabolism
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000569795.1, ENST00000569795.2, ENST00000569795.3, ENST00000569795.4, ENST00000569795.5, NR_136611, PARP6 , PARP6_HUMAN, Q2NL67, Q9H7C5, Q9H9X6, Q9HAF3, Q9NPS6, Q9UFG4, uc325zte.1, uc325zte.2
UCSC ID: ENST00000569795.6_7
RefSeq Accession: NM_001323532.2
Protein: Q2NL67 (aka PARP6_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.